Abstract：
:We studied the impact of acute glycerol-induced renal failure on blood levels and daily urinary excretion of arginine, monomethylarginine, and asymmetric and symmetric dimethylarginine. Acute renal failure was accompanied by enhanced daily excretion of asymmetric and symmetric dimethylarginine, increased plasma level of symmetric dimethylarginine, and decreased plasma level of arginine. Reabsorption of arginine and its methylated analogues decreased, thus compensating for reduced glomerular filtration rate. These data attest to increased production of dimethylarginines during acute renal failure. These changes can decrease NO bioavailability.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Sukhovershin RA,Gilinsky MAdoi
10.1007/s10517-012-1736-2subject
Has Abstractpub_date
2012-08-01 00:00:00pages
444-7issue
4eissn
0007-4888issn
1573-8221journal_volume
153pub_type
杂志文章abstract：:Threefold administration of benz(a)pyrene in a dose of 20 mg/kg markedly stimulated biliary excretion of lysosomal enzymes from rat liver without signs of lysosomal damage. Constant light exposure induced changes attesting to functional activation of the lysosomal apparatus in liver cells and inhibited constitutive bi...
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journal_title：Bulletin of experimental biology and medicine
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journal_title：Bulletin of experimental biology and medicine
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更新日期：2013-08-01 00:00:00
