Abstract：
:Apoptosis markers (p53, PUMA, p21, and Mdm2) were studied in patients with rheumatoid arthritis at the early and late stages of disease on bone marrow smears and frozen sections of the articular synovial membrane. The target molecules were found in all patients. The early stage was characterized by maximum expression of antiapoptotic (Mdm2) molecule and the minimum expression of proapoptotic molecules (p53, PUMA, and p21). The proapoptotic proteins predominated in patients with the late stage of rheumatoid arthritis, while the antiapoptotic factor (Mdm2) was depressed significantly. These data suggested total suppression of apoptosis at the early stage of rheumatoid arthritis and recommended the Mdm2 molecule as a prospective target for the development of new drugs.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Doroshevskaya AY,Kondratovskii PM,Dubikov AI,Eliseikina MGdoi
10.1007/s10517-014-2353-zsubject
Has Abstractpub_date
2014-01-01 00:00:00pages
377-80issue
3eissn
0007-4888issn
1573-8221journal_volume
156pub_type
杂志文章abstract：:We propose a noninvasive method of in vivo examination the hemostasis system based on speckle pattern analysis of coherent light scattering from the skin. We compared the results of measuring basic blood coagulation parameters by conventional invasive and noninvasive methods. A strict correlation was found between the...
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