Circulating Proteasomes in the Pathogenesis of Head and Neck Squamous Cell Carcinoma.

abstract：:We studied the effects of neurotensin dipeptide analog Dilept (N-caproyl-L-prolyl-L-tyrosine methyl ester) on dopamine metabolism and synthesis in the nucleus accumbens of Wistar rats. Dilept increased the levels of dopamine and its metabolites (homovanillic acid and dioxyphenylalanine) and stimulated dopamine turnove...

journal_title：Bulletin of experimental biology and medicine

authors： Shubenina EV,Kudrin VS,Klodt PM,Narkevich VB,Kuznetsova EA,Gudasheva TA,Ostrovskaya RU

更新日期：2012-09-01 00:00:00

abstract：:We studied the effect of transfection of PC-3 prostate cancer cells with a plasmid encoding shRNA complimentary to a fragment of integrin β4 (ITGB4). The results attest to considerable changes in the transcriptome of transfected cells. For instance, compensatory changes in the expression of integrin family genes were ...

journal_title：Bulletin of experimental biology and medicine

authors： Knyazev EN,Nyushko KM,Alekseev BY,Samatov TR,Shkurnikov MY

更新日期：2015-08-01 00:00:00

abstract：:Experiments of 42 outbred male albino rats (160-180 g) showed an increase in the content of CD64, fibroblast growth factor, and proapoptotic proteins (p53 and p21) in the renal cortical matter on day 45 of experimental chronic Masugi nephritis. A positive correlation between CD64 and fibroblast growth factor character...

journal_title：Bulletin of experimental biology and medicine

authors： Rogovyi YE,Arkhipova LG,Dikal MV,Filipova LO,Mil' EN

更新日期：2007-10-01 00:00:00

abstract：:Local injection of 4 nmol moxonidine (unilaterally) into the rostroventrolateral medulla of spontaneously hypertensive rats (SHR-SP) decreased mean blood pressure and heart rate by 24+/-3 and 3+/-4%, respectively. Pretreatment with the I1/alpha2-receptor antagonist efaroxan abolished the moxonidine-induced decrease in...

journal_title：Bulletin of experimental biology and medicine

authors： Khokhlova ON,Murashev AN,Medvedev OS

更新日期：2001-04-01 00:00:00

abstract：:Administration of granulocyte CSF preparation to patients with chronic heart failure produced a hemostimulating effect and increased the content of leukocytes and neutrophils in the peripheral blood. Granulocyte CSF induced mobilization of bone marrow progenitor cells into the peripheral blood. The content of hemopoie...

journal_title：Bulletin of experimental biology and medicine

authors： Konenkov VI,Pokushalov EA,Poveshchenko OV,Kim II,Romanov AB,Guleva NA,Bernvald VV,Soloviova AO,Yankayte EV,Poveshchenko AF,Karaskov AM

更新日期：2012-05-01 00:00:00

abstract：:Morphometric analysis of structural and functional changes in the human mesenteric lymph nodes during aging revealed the development of fibrous connective tissue, fragmentation of the lymphoid parenchyma, the absence of follicles with germinal centers, and a decrease in the level of lymphocyte proliferation, which was...

journal_title：Bulletin of experimental biology and medicine

authors： Erofeeva LM,Mnikhovich MV

更新日期：2020-03-01 00:00:00

abstract：:Fibroblasts isolated from skin biopsy specimens from patients with genetic forms of Parkinson's disease, carriers of mutations in LRRK2 and PARK2 genes, and from a healthy volunteer were reprogrammed using lentiviral vectors into induced pluripotent stem cells (iPSC). iPSC were differentiated into neuron-like cells us...

journal_title：Bulletin of experimental biology and medicine

authors： Konovalova EV,Novosadova EV,Grivennikov IA,Illarioshkin SN

更新日期：2015-10-01 00:00:00

abstract：:We studied the specific features of ultrasonic vocalization of Wistar rats in various motivational and emotional states. No significant changes were found in ultrasonic vocalization of rats during experimental food motivation and after the satisfaction of food requirements. The state of thirst and satisfaction of wate...

journal_title：Bulletin of experimental biology and medicine

authors： Pertsov SS,Koplik EV,Karkishchenko NN,Sudakov KV

更新日期：2012-10-01 00:00:00

abstract：:The level of expression of CD11b and HLA-DR surface molecules on monocyte-like THP-1 cells increased significantly as a result of transmigration of these cells through a monolayer of endothelial cells. The expression of all studied markers (CD11b, HLA-DR, and CD-14) increased significantly after transendothelial migra...

journal_title：Bulletin of experimental biology and medicine

authors： Starikova EA,Sokolov DI,Chernova AA,Freidlin IS

更新日期：2008-11-01 00:00:00

abstract：:Electron microscopy of the pineal gland in gamma-irradiated rats treated with epithalon revealed ultrastructural signs attesting to enhancement of its functional activity. ...

journal_title：Bulletin of experimental biology and medicine

authors： Khavinson VK,Yakovleva ND,Popuchiev VV,Kvetnoi IM,Manokhina RP

更新日期：2001-01-01 00:00:00

abstract：:We studied changes in cerebral and central hemodynamics during active orthostatic load in 26 healthy men aging 20-26 years. Two types of central hemodynamics were revealed: progressive increase in blood pressure throughout the test (type 1) or initial blood pressure increase followed by its decrease with maximum incre...

journal_title：Bulletin of experimental biology and medicine

authors： Zabolotskikh NV

更新日期：2008-05-01 00:00:00

abstract：:Isolated rat hearts were subjected to 30-min coronary artery occlusion followed by 120-min reperfusion. The hearts (n=8-12) were perfused with Krebs-Henseleit solution enriched with L-carnitine (0.5, 2.5 and 5 mM) for 10 min before and after ischemia or reperfusion and for the whole period of ischemia and reperfusion....

journal_title：Bulletin of experimental biology and medicine

authors： Najafi M,Garjani A,Maleki N,Eteraf Oskouei T

更新日期：2008-08-01 00:00:00

abstract：:Acute experiments on cats showed that dynorphin A(1-13) modulates pulse activity of afferent neurons and interneurons in the bulbar cardiovascular center against the background of stable blood pressure. ...

journal_title：Bulletin of experimental biology and medicine

authors： Mikhailova SD,Vasil'eva TV,Semushkina TM,Storozhakov GI

更新日期：2003-01-01 00:00:00

abstract：:We studied the mechanisms of combined action of clonidine and local anesthetics amethocaine and imidazo-benzimidazole derivative RU-1117. In contrast to amethocaine, RU-1117 in therapeutic concentrations binds to imidazoline receptors and, to a lesser extent, to alpha(2A)-adrenoceptors on human platelets. Clonidine an...

journal_title：Bulletin of experimental biology and medicine

authors： Ponomarev VP,Galenko-Yaroshevskii AP,Dukhanin AS,Anisimova VA

更新日期：2003-07-01 00:00:00

abstract：:Structural characteristics of the adrenal medulla in hypertensive NISAG rats (hereditary stress-induced arterial hypertension) were studied during various periods of postnatal ontogeny. Signs of hyperplasia of the adrenal medulla were most pronounced in adult hypertensive animals with persistent arterial hypertension,...

journal_title：Bulletin of experimental biology and medicine

authors： Buzueva II,Filyushina EE,Shmerling MD,Markel AL,Yakobson GS

更新日期：2006-12-01 00:00:00

abstract：:We studied the effect of melatonin on the relationship between LPO intensity and proteolytic activity in basal nuclei (caudate nucleus, globus pallidus, amygdaloid complex, and nucleus accumbens septi) of rat brain during acute hypobaric hypoxia. Acute hypoxia was accompanied by LPO activation and increase in proteoly...

journal_title：Bulletin of experimental biology and medicine

authors： Sopova IY,Zamorskii II

更新日期：2006-07-01 00:00:00

abstract：:We studied brown adipose tissue isolated from mice receiving 20% ethanol as a single source of fluid. In vitro O2 utilization by brown adipose tissue decreased after one month of forced alcohol intake, but surpassed the control after 3 months of ethanol drinking. The absolute and relative weight of brown adipose tissu...

journal_title：Bulletin of experimental biology and medicine

authors： Elsukova EI,Medvedev LN,Kudryavtseva NA

更新日期：2001-12-01 00:00:00

abstract：:Peroral administration of alpha-tocopherol in a daily dose of 150 mg/kg for 1, 4, 8, and 12 days leads to induction of cytochromes P450 1A in male rats. Activity of CYP1A1 and CYP1A2 increased most significantly one day after alpha-tocopherol administration (by 2.6 and 2.7 times, respectively). CYP1A1 was immunohistoc...

journal_title：Bulletin of experimental biology and medicine

authors： Sidorova YA,Grishanova AY,Lyakhovich VV

更新日期：2004-09-01 00:00:00

abstract：:We studied the effects of plant extracts and products of their biological treatment on trans-sialidase activity in human blood plasma. Extracts of kelp, fucus, yarrow, Saint John's wort, onion, and honey in vitro decreased trans-sialidase activity. Extracts of pollen (beebread) and garlic powder produced the maximum i...

journal_title：Bulletin of experimental biology and medicine

authors： Aksenov DV,Kaplun VV,Tertov VV,Sobenin IA,Orekhov AN

更新日期：2007-01-01 00:00:00

abstract：:Dihydroquercetin (flavonoid of plant origin) immobilized with an amino acid in lecithin nanoparticles promotes reduction of inflammatory reactions in the wound after thermal burn. The use of a liposomal complex in burn injury stabilizes endogenous antioxidant system and limits the secondary necrotic zone in the wounds...

journal_title：Bulletin of experimental biology and medicine

authors： Naumov AA,Shatalin YV,Potselueva MM

更新日期：2010-07-01 00:00:00

abstract：:A stable preparation of agaricinic acid nanoparticles was obtained. The mean hydrodynamic size of nanoparticles according to photon correlation spectroscopy was 200 nm and zeta potential was -57 mV. Cytotoxic activity of agaricinic acid nanoparticles against human HepG2 hepatoma cells was evaluated. Nanoparticles with...

journal_title：Bulletin of experimental biology and medicine

authors： Gudkova OI,Demchenko AG,Shvets AV,Kuryakov VN,Sedyakina NE,Lyundup AV,Feldman NB,Gromovykh TI,Lutsenko SV

更新日期：2020-08-01 00:00:00

abstract：:o-Aminoazotoluene in noncarcinogenic doses promoted the development of liver tumors in female ICR mice induced by administration of diethylnitrosamine during early ontogeny. Severe inflammatory infiltration and proliferation of oval cells were found in liver tissue of these animals. The concentration of free thyroxin ...

journal_title：Bulletin of experimental biology and medicine

authors： Baginskaya NV,Il'nitskaya SI,Nikitenko EV,Kaledin VI

更新日期：2007-12-01 00:00:00

abstract：:Changes in cerebral neurogenesis provoked by ischemia and the effect of fluoxetine on this process were studied using a three-vessel occlusion model of global transient cerebral ischemia. The global transient cerebral ischemia was modeled on male Wistar rats by transient occlusion of three major vessels originating fr...

journal_title：Bulletin of experimental biology and medicine

authors： Khodanovich MY,Kisel' AA,Chernysheva GA,Smol'yakova VI,Savchenko RR,Plotnikov MB

更新日期：2016-07-01 00:00:00

abstract：:We compared the level of transforming growth factor-β1 (TGF-β1) in the tear fluid of 20 patients with high myopia who underwent transepithelial photorefractive keratectomy (T-PRK) in one eye and laser subepithelial keratomileusis (LASEK) in the contralateral eye. Tear fluid samples were collected with scaled microcapi...

journal_title：Bulletin of experimental biology and medicine

authors： Chen JJ,Yang YF,Zeng Y

更新日期：2020-11-01 00:00:00

abstract：:Olivomycin (DNA-binding antibiotic) in nanomolar concentrations induces apoptosis of human tumor cells and inhibits p53-dependent transcription of the reporter gene (basal and induced by antitumor drugs). Olivomycin aglycon induces no cytotoxicity and does not block transcription. ...

journal_title：Bulletin of experimental biology and medicine

authors： Simonova VS,Samusenko AV,Filippova NA,Tevyashova AN,Lyniv LS,Kulik GI,Chekhun VF,Shtil AA

更新日期：2005-04-01 00:00:00

abstract：:Changes in the amplitude and dynamic parameters of purposive saccades were studied in monkeys with MPTP-induced Parkinson-like syndrome. Lengthening of saccade latency, decreased maximum velocity of eye movements, and impaired saccade accuracy were observed at the early stages MPTP-syndrome. Different disturbances of ...

journal_title：Bulletin of experimental biology and medicine

authors： Tereshchenko LV,Yudin AG,Kuznetsov Y,Latanov AV,Shul'govskii VV

更新日期：2002-02-01 00:00:00

abstract：:Enzyme immunoassay of the serum neurospecific antigens (gliofibrillar acid protein and neurospecific enolase) was used for evaluation of the resistance of the blood-brain barrier in Wistar rats with perinatal hypoxia and ischemia of the CNS. Perinatal hypoxia and ischemia of the CNS was modeled by two methods: ligatio...

journal_title：Bulletin of experimental biology and medicine

authors： Chekhonin VP,Lebedev SV,Dmitrieva TB,Blinov DV,Gurina OI,Semenova AV,Volodin NN

更新日期：2003-09-01 00:00:00

abstract：:The paper analyzes theoretical models of the adaptive modes of generation and stability of human heart as a nonlinear point source. The analysis encompasses only ECG time-domain dynamics. To solve the general problem of the study of the adaptive changes of the cardiosignal under the action of external periodic force a...

journal_title：Bulletin of experimental biology and medicine

authors： Pipin VV,Ragulskaya MV,Chibisov SM

更新日期：2010-10-01 00:00:00

abstract：:The role of signaling molecules in synthesis of humoral regulators of granulocytopoiesis by the hematopoietic microenvironmental cells during stress was analyzed using specific inhibitors. The major role in stimulation of the synthesis of granulocytic CSF during stressful stimulation is played by PI3K/Akt signaling ca...

journal_title：Bulletin of experimental biology and medicine

authors： Zhdanov VV,Miroshnichenko LA,Udut EV,Polyakova TY,Zyuz'kov GN,Simanina EV,Sherstoboev EY,Stavrova LA,Agafonov VI,Minakova MY,Dygai AM

更新日期：2019-01-01 00:00:00

abstract：:Ten-minute perfusion of intact isolated rat heart with Krebs-Henseleit solution containing delta-opioid receptor agonists (DPDPE, (-)-TAN-67) or delta-opioid receptor antagonists (naltrindole, TIPP[psi], ICI 174,864) at a final concentration of 0.1 mg/liter decreased HR, blood pressure in the left ventricle, and the r...

journal_title：Bulletin of experimental biology and medicine

authors： Maslov LN,Lishmanov YB,Barzakh EI,Lasukova TV,Rice KK,Oeltgen PR

更新日期：2006-04-01 00:00:00