Transcriptional activation of cytochrome P450 1A1 with alpha-tocopherol.

Abstract:

:Peroral administration of alpha-tocopherol in a daily dose of 150 mg/kg for 1, 4, 8, and 12 days leads to induction of cytochromes P450 1A in male rats. Activity of CYP1A1 and CYP1A2 increased most significantly one day after alpha-tocopherol administration (by 2.6 and 2.7 times, respectively). CYP1A1 was immunohistochemically detected in rat liver microsomes during this period. The content of CYP1A1 mRNA significantly increased in the liver. The amount of CYP1A2 mRNA and regulatory proteins for signal activation of CYP1A1 (AhR and Arnt) remained unchanged after treatment with alpha-tocopherol.

journal_name

Bull Exp Biol Med

authors

Sidorova YA,Grishanova AY,Lyakhovich VV

doi

10.1007/s10517-005-0007-x

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

233-6

issue

3

eissn

0007-4888

issn

1573-8221

pii

doi

journal_volume

138

pub_type

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