Abstract：
:Enzyme immunoassay of the serum neurospecific antigens (gliofibrillar acid protein and neurospecific enolase) was used for evaluation of the resistance of the blood-brain barrier in Wistar rats with perinatal hypoxia and ischemia of the CNS. Perinatal hypoxia and ischemia of the CNS was modeled by two methods: ligation of the common carotid artery in 7-day-old rats followed by 3.5-h hypoxic hypoxia or 15-min anoxic exposure of fetuses isolated via hysterectomy on day 21 of gestation. Enzyme immunoassay of serum gliofibrillar acid protein and neurospecific enolase in control an experimental rat pups was carried out once a week during 3 months. In controls serum levels of gliofibrillar acid protein and neurospecific enolase virtually did not change during postnatal development, while in animals with cerebral hypoxia and ischemia induced in fetuses by both methods serum concentration of neurospecific enolase sharply increased 1 week after the injury and increased on weeks 6 and 10. The content of gliofibrillar acid protein was maximum on week 1 and later considerably varied, the peaks of its concentrations observed on weeks 3 and 8 preceded the increase in neurospecific enolase activity in peripheral blood.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Chekhonin VP,Lebedev SV,Dmitrieva TB,Blinov DV,Gurina OI,Semenova AV,Volodin NNdoi
10.1023/b:bebm.0000008978.27644.4bsubject
Has Abstractpub_date
2003-09-01 00:00:00pages
261-5issue
3eissn
0007-4888issn
1573-8221journal_volume
136pub_type
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