Abstract：
:The risk of essential arterial hypertension was assessed in carriers of the NOS2 gene variants (rs1800482 (-954G>C), rs3730017 (C>T)). In subjects carrying C allele (rs1800482), the risk for essential arterial hypertension developing was higher by 1.7 times (OR=1.712, 95%CI 1.07-2.74), while the presence of T-allele (rs3730017) had a protective effect (OR=0.304, 95%CI 0.192-0.482). In patients with essential arterial hypertension, the presence of the C allele (rs1800482) was associated with a higher content of NO metabolites in the blood plasma. A positive correlation was found between the plasma content of nitrites and nitrates and the level of transcripts of VCAM1, ICAM1 genes in peripheral blood leukocytes. We found the influence of the C allele carriership on the expression VCAM1 and ICAM1 genes in patients with essential hypertension. It was hypothesized that this polymorphic site in the NOS2 gene can be involved in the development of endothelial dysfunction and essential arterial hypertension through modulation of NO level under condition of inflammation.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Topchieva LV,Balan OV,Korneeva VA,Malysheva IEdoi
10.1007/s10517-019-04652-4subject
Has Abstractpub_date
2019-11-01 00:00:00pages
79-83issue
1eissn
0007-4888issn
1573-8221pii
10.1007/s10517-019-04652-4journal_volume
168pub_type
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