Abstract:
:We studied the effect of 10-week treatment with intranasal insulin (0.5 IU/day) on glucose tolerance, glucose utilization, lipid metabolism, functions of pancreatic β cells, and insulin system in the liver of rats with cafeteria diet-induced metabolic syndrome. The therapy reduced body weight and blood levels of insulin, triglycerides, and atherogenic cholesterol that are typically increased in metabolic syndrome, normalized glucose tolerance and its utilization, and increased activity of insulin signaling system in the liver, thus reducing insulin resistance. The therapy did not affect the number of pancreatic islets and β cells. The study demonstrates prospects of using intranasal insulin for correction of metabolic parameters and reduction of insulin resistance in metabolic syndrome.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Derkach KV,Ivantsov AO,Chistyakova OV,Sukhov IB,Buzanakov DM,Kulikova AA,Shpakov AOdoi
10.1007/s10517-017-3762-6subject
Has Abstractpub_date
2017-06-01 00:00:00pages
184-189issue
2eissn
0007-4888issn
1573-8221pii
10.1007/s10517-017-3762-6journal_volume
163pub_type
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