Abstract:
:Nanocrystalline particles of chitin in the form of hydrosol in a concentration of 0.63 mg/ml have no effect on aggregation of human platelets and clotting time of platelet-poor plasma in coagulation tests. ADP-induced aggregation of human platelets was inhibited by these nanoparticles in concentrations of 0.63 and 1.00 mg/ml in comparison with the control. Intravenous administration of nanoparticles in a dose of 1 mg/kg to guinea pigs produced no anticoagulant effect. The nanocrystalline particles of chitin can be of interest as potential drug delivery systems.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Drozd NN,Torlopov MA,Udoratina EV,Logvinova YSdoi
10.1007/s10517-018-4076-zsubject
Has Abstractpub_date
2018-04-01 00:00:00pages
766-769issue
6eissn
0007-4888issn
1573-8221pii
10.1007/s10517-018-4076-zjournal_volume
164pub_type
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