Abstract：
:We studied the effects of stress exposure during the adolescent period of development (SAPD) on the parameters of inflammatory painful response and the level of depression-like behavior in prenatally stressed adult male rats. In addition, we analyzed the effects of selective serotonin (5-HT) reuptake inhibitor fluoxetine and 5-HT1A receptor agonist buspirone injected chronically to pregnant mothers for correction of behavioral disturbances caused by prenatal stress in their adult male progeny. In the formalin test, SAPD decreased integrated at the supraspinal level pain-like response that was increased by prenatal stress; under these conditions, buspirone and fluoxetine were ineffective in contrast to their antinociceptive action on spinally integrated pain-like response increased by SAPD. In the forced swimming test, SAPD had no effect on the level of depression-like behavior in prenatally stressed males; no differences in plasma corticosterone level were found in these animals.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Butkevich IP,Mikhailenko VAdoi
10.1007/s10517-020-04875-wsubject
Has Abstractpub_date
2020-07-01 00:00:00pages
306-309issue
3eissn
0007-4888issn
1573-8221pii
10.1007/s10517-020-04875-wjournal_volume
169pub_type
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