Plasma Cytokines Profile in Patients with Parkinson's Disease Associated with Mutations in GBA Gene.

Abstract:

:Plasma cytokine concentration in patients with Parkinson's disease and mutation in GBA gene, in patients with sporadic Parkinson's disease, and in healthy volunteers were measured by ELISA and multiplex analysis. In patients with Parkinson's disease and mutation in GBA gene, elevated plasma concentrations of IL-1β and TNFα were revealed by ELISA in comparison with both controls and patients with sporadic form of Parkinson's disease. Multiplex analysis revealed enhanced secretion of IL-1β, IL-2, IFNγ and reduced plasma levels of monocyte chemoattractant protein-1 (MCP-1) in patients with Parkinson's disease and mutation in GBA gene (in comparison with other groups) and increased plasma levels of IL-13 (only in comparison with the healthy volunteers). Our results support the hypothesis that the concentrations of inflammatory mediators are increased in patients with Parkinson's disease and mutation in GBA gene.

journal_name

Bull Exp Biol Med

authors

Miliukhina IV,Usenko TS,Senkevich KA,Nikolaev MA,Timofeeva AA,Agapova EA,Semenov AV,Lubimova NE,Totolyan AA,Pchelina SN

doi

10.1007/s10517-020-04723-x

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

423-426

issue

4

eissn

0007-4888

issn

1573-8221

pii

10.1007/s10517-020-04723-x

journal_volume

168

pub_type

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