Abstract:
:Plasma cytokine concentration in patients with Parkinson's disease and mutation in GBA gene, in patients with sporadic Parkinson's disease, and in healthy volunteers were measured by ELISA and multiplex analysis. In patients with Parkinson's disease and mutation in GBA gene, elevated plasma concentrations of IL-1β and TNFα were revealed by ELISA in comparison with both controls and patients with sporadic form of Parkinson's disease. Multiplex analysis revealed enhanced secretion of IL-1β, IL-2, IFNγ and reduced plasma levels of monocyte chemoattractant protein-1 (MCP-1) in patients with Parkinson's disease and mutation in GBA gene (in comparison with other groups) and increased plasma levels of IL-13 (only in comparison with the healthy volunteers). Our results support the hypothesis that the concentrations of inflammatory mediators are increased in patients with Parkinson's disease and mutation in GBA gene.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Miliukhina IV,Usenko TS,Senkevich KA,Nikolaev MA,Timofeeva AA,Agapova EA,Semenov AV,Lubimova NE,Totolyan AA,Pchelina SNdoi
10.1007/s10517-020-04723-xsubject
Has Abstractpub_date
2020-02-01 00:00:00pages
423-426issue
4eissn
0007-4888issn
1573-8221pii
10.1007/s10517-020-04723-xjournal_volume
168pub_type
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