Abstract:
:We compared cytotoxic activity of blood mononuclear leukocytes from healthy donors and lymphokine-activated killer cells generated from them towards tumor and normal cells. Lymphokine-activated killer cells exhibited higher (in comparison with blood mononuclear leukocytes) killer activity towards tumor cells. Lymphokine-activated cells and mononuclear leukocytes had no lytic effect on non-transformed eukaryotic cells. Hence, we demonstrated selective cytotoxic activity of effector cells (lymphokine-activated killers) towards tumor cells of different origin (but not normal cells).
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Zhukova OS,Lebedinskaya OV,Shubina IZh,Gerasimova GK,Karamzin AM,Kiselevskii MVdoi
10.1007/s10517-007-0033-ysubject
Has Abstractpub_date
2007-01-01 00:00:00pages
132-5issue
1eissn
0007-4888issn
1573-8221journal_volume
143pub_type
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