Abstract：
:Homocysteine and homocysteic acid increased the stationary level of reactive oxygen species in rat lymphocytes, homocysteic acid being more potent in this respect. The effect of this compound was realized via ionotropic NMDA receptors and group III metabotropic glutamate receptors. Incubation of lymphocytes with homocysteic acid increased intracellular Ca(2+)concentration, activated of protein kinase C, and induced accumulation of reactive oxygen species, which reflected the involvement of homocysteic acid into cell signaling mechanisms.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Vladychenskaya EA,Tyulina OV,Boldyrev AAdoi
10.1007/s10517-006-0288-8subject
Has Abstractpub_date
2006-07-01 00:00:00pages
47-50issue
1eissn
0007-4888issn
1573-8221pii
doijournal_volume
142pub_type
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