Abstract:
:Oxidative kidney injury was compared in newborn and adult rats under conditions of ischemia/reperfusion and in experimental model of systemic inflammation induced by endotoxin (LPS of bacterial cell wall) administration. Oxidative stress in the kidney accompanied both experimental models, but despite similar oxidative tissue damage, kidney dysfunction in neonates was less pronounced than in adult animals. It was found that neonatal kidney has a more potent regenerative potential with higher level of cell proliferation than adult kidney, where the level proliferating cell antigen (PCNA) increased only on day 2 after ischemia/reperfusion. The pathological process in the neonatal kidney developed against the background of active cell proliferation, and, as a result, proliferating cells could almost immediately replace the damaged structures. In the adult kidney, regeneration of the renal tissue was activated only after significant loss of functional nephrons and impairment of renal function.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Pevzner IB,Pavlenko TA,Popkov VA,Andrianova NV,Zorova LD,Brezgunova AA,Zorov SD,Yankauskas SS,Silachev DN,Zorov DB,Plotnikov EYdoi
10.1007/s10517-018-4127-5subject
Has Abstractpub_date
2018-06-01 00:00:00pages
189-194issue
2eissn
0007-4888issn
1573-8221pii
10.1007/s10517-018-4127-5journal_volume
165pub_type
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