Dynamics of tumor growth in Brattleboro and WAG rats injected with Walker 256 carcinosarcoma cells in different doses.

Abstract:

:The peculiarities of Walker 256 tumor growth depending on the dose of transplanted cells were studied in rats differing by vasopressin production. Transplantation of 10(5) cells does not lead to tumor development. The dose of 7 x 10(5) cells induces progressively growing tumors in WAG rats, while in Brattleboro rats tumors regressed after a short period of growth. Increasing the dose to 2.8 x 10(6) cells was inessential for the dynamics of tumor growth in WAG rats, but stimulated regression of tumor growth in Brattleboro rats, producing no vasopressin. This dose dependence suggests the involvement of the immune system into the dynamics of tumor growth.

journal_name

Bull Exp Biol Med

authors

Khegay II,Popova NA,Ganilova LS,Shnyder EP,Ivanova LN

doi

10.1007/s10517-008-0001-1

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

81-3

issue

1

eissn

0007-4888

issn

1573-8221

journal_volume

145

pub_type

杂志文章
  • Effect of carnosine and related compounds on proliferation of cultured rat pheochromocytoma PC-12 cells.

    abstract::The study was undertaken to determine the mechanism of carnosine effect on cell proliferation. We studied the effect of carnosine and its derivatives on cell cycle progression in cultured rat pheochromocytoma cells (PC-12). It was found that 48-h incubation of PC-12 cells with carnosine in concentrations of 10-50 mM l...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-012-1894-2

    authors: Rybakova YS,Boldyrev AA

    更新日期:2012-11-01 00:00:00

  • Effect of Coenzyme Q10 on Expression of UbiAd1 Gene in Rat Model of Local Cerebral Ischemia.

    abstract::The study examined the effect of endogenous lipid-soluble antioxidant coenzyme Q10 on the expression of UbiA gene of prenyltransferase domain-containing protein 1 (UbiAd1) involved in synthesis of vitamin K2 (and probably of coenzyme Q10) on a rat model of ischemic stroke provoked by ligation of the middle cerebral ar...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-018-4101-2

    authors: Povarova OV,Balatsky AV,Gusakov VS,Medvedev OS

    更新日期:2018-05-01 00:00:00

  • Trophoblastic beta1-glycoprotein and hemostasis system in pregnant women with antiphospholipid syndrome.

    abstract::Clinical and laboratory studies were carried out in 38 pregnant women with antiphospholipid syndrome. Increased functional activity of platelets and decreased protein-producing function of the placenta were observed starting from the early terms of gestation. These disorders were followed by the development of hyperco...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1021928903012

    authors: Bogdanovich RN,Chikalovets IV

    更新日期:2002-10-01 00:00:00

  • Effect of 2-aminoadamantane derivatives on behavior of mice in a modified light/dark test.

    abstract::The effects of two derivatives of 2-aminoadamantane, enantiomers J447H and J579, on the behavior of male and female C57Bl/6J mice were studied using a modified light/dark test. The substances differed by their effects on the behavior of male mice. J579 reduced the number of rearings. J447H in a dose of 1 mg/kg affecte...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-014-2725-4

    authors: Avgustinovich DF,Fomina MK,Suslov EV,Tolstikova TG,Volcho KP,Salakhutdinov NF

    更新日期:2014-12-01 00:00:00

  • Effect of Metabolic Stress on Coenzyme Q10 Content in Tissues of Active and Passive Rats.

    abstract::The dynamics of coenzyme Q10 concentration in the blood plasma, liver, and brain of passive and active rats was studied on the model of metabolic stress. This parameter was shown to differ in rats with various patterns of behavior. Dietary consumption of coenzyme Q10 in doses of 10 and 100 mg/kg body weight was follow...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-016-3478-z

    authors: Kirbaeva NV,Sharanova NE,Baturina VA,Zhminchenko VM,Pertsov SS,Vasil'ev AV

    更新日期:2016-09-01 00:00:00

  • Morphofunctional basis for recovery of locomotor movements in rats with completely crossed spinal cord.

    abstract::Treadmill training of spinalized rats creates conditions for early appearance of rhythmic locomotor movements of the hind limbs. Recovery of the movements was paralleled by an appropriate structural organization of neurons in the anterior horns of the distal compartment of the spinal cord. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/b:bebm.0000048388.76324.9c

    authors: Moshonkina TR,Gilerovich EG,Fedorova EA,Avelev VD,Gerasimenko YP,Otellin VA

    更新日期:2004-08-01 00:00:00

  • Effect of factors produced by the placenta on cytokine secretion by THP-1 cells cultured on a 3D scaffold.

    abstract::We compared the effects of soluble products from the placenta obtained from women with normal pregnancy and pregnancy complicated by preeclampsia on cytokine secretion by THP-1 cells cultured on a 3D Matrigel scaffold. In the presence of soluble products from all placentas, the cells actively secreted IL-8, MCP-1, and...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-014-2397-0

    authors: Onokhina YS,L'vova TY,Tsitskarava DZ,Koren'kov DA,Sel'kov SA,Sokolov DI

    更新日期:2014-02-01 00:00:00

  • Morphofunctional characteristics of fetoplacental barrier of placental villi during pregnancy complicated by herpes-virus infection.

    abstract::Analysis of placenta homogenate from pregnant women having an episode of herpes-virus infection during the third trimester revealed suppression of Bcl-2 protein activity and increase in caspase 3 concentration. Activity of Bcl-2 protein decreases with increasing the titer of antibodies to herpes virus. Increased caspa...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-010-0987-z

    authors: Lutsenko MT,Andrievskaya IA

    更新日期:2010-10-01 00:00:00

  • Variations in the number of regulatory T cells (CD4+CD25+) in patients with breast cancer during herceptin therapy.

    abstract::We studied the effect of Herceptin therapy on the population composition of lymphocytes and percentage of CD4+CD25+ cells (regulatory T cells) in breast cancer patients. Herceptin treatment decreased the number of "professional" T suppressors (CD4+CD25+ cells and regulatory T cells) in the peripheral blood. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s10517-006-0171-7

    authors: Slavina EG,Chertkova AI,Zabotina TN,Gan'shina IP,Lichinitser MR

    更新日期:2006-03-01 00:00:00

  • Assessment of therapeutic drug efficiency.

    abstract::The efficiency of drug therapy should be evaluated by not only its directed action on specific organ or target parameter, but also its effects on general regulatory and adaptive status. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10517-008-0195-2

    authors: Pokrovskii VM,Kompaniets OG

    更新日期:2008-06-01 00:00:00

  • Method for Studying the Myocardial Blood Flow Reserve by Load Dynamic Single-Photon Emission Computed Tomography.

    abstract::We developed a method for collection and processing of scintigraphic data to estimate myocardial reserve in a gamma-chamber with cadmium-zinc-telluride detectors. Dynamic single-photon emission computed tomography of the heart with (99m)Tc-Technetril was performed in 16 coronary heart disease patients at rest and duri...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-016-3328-z

    authors: Mochula AV,Zavadovsky KV,Lishmanov YB

    更新日期:2016-04-01 00:00:00

  • Induction of immune complexes and autoantibodies to serotonin and dopamine in patients with Alzheimer's disease.

    abstract::Plasma concentration of immune complexes and antibodies to serotonin and dopamine were higher in patients with Alzheimer's disease compared to mentally healthy volunteers of the same age. Plasma concentrations of antibodies to serotonin and dopamine decreased with the increase in the duration of this disease. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1020692218416

    authors: Davydova TV,Mikovskaya OI,Fomina VG,Voskresenskaya NI,Doronina OA

    更新日期:2002-07-01 00:00:00

  • Dynamics of chromosomal aberrations in male mice of various strains during aging.

    abstract::We studied the incidence of chromosome aberrations in bone marrow cells and primary spermatocytes in various mouse strains. Experiments were performed on SAMP mice (accelerated aging), control SAMR mice, and long-living CBA and SHR mice. Experiments revealed a positive correlation between the age and the incidence of ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1017940418751

    authors: Rozenfel'd SV,Togo EF,Mikheev VS,Popovich IG,Zabezhinskii MA,Anisimov VN

    更新日期:2001-05-01 00:00:00

  • Immunoprotective effects of prolactin during stress-induced immune dysfunction.

    abstract::We showed for the first time that prolactin stimulates the synthesis and release of immunomodulating cytokines and lymphocyte-activating factors (e.g., interleukin-1) by peritoneal macrophages. Prolactin abolished the stress-induced inhibition of proliferation of peripheral blood lymphocytes and increased cell sensiti...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/b:bebm.0000042707.46061.5d

    authors: Fomicheva EE,Nemirovich-Danchenko EA,Korneva EA

    更新日期:2004-06-01 00:00:00

  • Immunocytochemical analysis of proliferative activity of endometrial and myometrial cell populations in focal and stromal adenomyosis.

    abstract::Immunocytochemical study has shown that Ki-67 antigen is detected in adenomyosis in both endometrial and myometrial cell populations (in the eutopic and ectopic endometrial glandular epithelium, stromal cells, smooth muscle cells, and vascular endotheliocytes of the endometrium and myometrium), the label index differi...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-013-2190-5

    authors: Nepomnyashchikh LM,Lushnikova EL,Molodykh OP,Pichigina AK

    更新日期:2013-08-01 00:00:00

  • Antibacterial Activity of L-Lysine-α-Oxidase from the Trichoderma.

    abstract::We studied the effects of a concentrate of metabolites of Trichoderma harzianum Rifai F-180, an active producer of L-lysine-α-oxidase, and homogenous enzyme on a highly virulent bacteria Erwinia amylovora. The producer of antitumor and antiviral Trichoderma enzyme L-lysine-α-oxidase was cultured on a processing system...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-017-3901-0

    authors: Smirnova IP,Karimova EV,Shneider YA

    更新日期:2017-10-01 00:00:00

  • On Methods for the Analysis of Indefinite Stimuli Perception Characteristics: an fMRT Study of Gender-Specific Differences.

    abstract::Comparative identification of cerebral regions activated in men and women during perception of indefinite images was carried out by fMRT and psychological testing. Nine men and nine women aged 20-26 years took part in the study. The volunteers examined simple geometric figures, slightly structurized images (tables fro...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10517-016-3431-1

    authors: Fyodorov AA,Pervushina ON,Bliznyuk MV,Khoroshilov BM,Melnikov ME,Mazhirina KG,Stark MB,Savelov AA,Petrovsky ED,Kozlova LI

    更新日期:2016-07-01 00:00:00

  • Modulation of α-rhythm and autonomic status of human by color photostimulation.

    abstract::The effects of photostimulation with different colors on α-rhythm amplitude and parameters of variation pulsometry were studied. Green color stimulation modulates human functions: ?-rhythm amplitude increases by 1.06 μV/√Hz (p<0.05) and the index of regulatory systems strain decreases significantly (p<0.05). ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-010-1046-5

    authors: Osipova MA,Arkov VV,Tonevitsky AG

    更新日期:2010-11-01 00:00:00

  • Effect of Activation of Peripheral Ion Channel TRPM8 on Gene Expression of Thermosensitive TRP Ion Channels in the Hypothalamus. Comparison with the Effect of Cooling.

    abstract::Experiments on rats showed that activation of the peripheral ion channel TRPM8 with menthol and rapid cooling (decrease in core temperature by 3°C) led to 1.5-fold activation of the expression of TRPV3 ion channel gene in the posterior hypothalamus, but had no effect on the expression of this gene in the anterior hypo...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-018-4311-7

    authors: Kozyreva TV,Evtushenko AA,Voronova IP,Khramova GM,Kozaruk VP

    更新日期:2018-12-01 00:00:00

  • Effect of photodynamic therapy with photodithazine on morphofunctional parameters of M-1 sarcoma.

    abstract::Efficiency and mechanisms of action of photodynamic therapy of M-1 sarcoma were studied experimentally on rats using photodithazine, a novel chlorine photosensitizer. The tissue and cellular targets for this agent are vascular wall, plasma membrane of tumor cells, and intracellular structures responsible for prolifera...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-005-0133-5

    authors: Romanko YS,Tsyb AF,Kaplan MA,Popuchiev VV

    更新日期:2004-12-01 00:00:00

  • Evaluation of serum antioxidant activity in patients with liver pathology by the chemiluminescent method.

    abstract::Total antioxidant activity of the serum in patients with liver pathology was assessed by two chemiluminescent methods based on different models of free radical oxidation: Hb-H2O2-luminol and ABAP-luminol. Comparative analysis showed a significant, but not high correlation of the results (r=0.798), which can be explain...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-014-2742-3

    authors: Titov VN,Sazhina NN

    更新日期:2014-12-01 00:00:00

  • Correction of furosemide-induced magnesium deficiency with different stereoisomers of organic magnesium salts: a comparative study.

    abstract::We compared the efficiency of different stereoisomers of organic magnesium salts (Mg DL-, Mg D-, and Mg L-aspartate and Mg L- and Mg DL-glutamate) after oral administration under conditions of furosemide-induced magnesium deficiency. The time to complete compensation of erythrocyte magnesium level was 5 days for Mg L-...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-011-1323-y

    authors: Spasov AA,Ozerov AA,Iezhitsa IN,Kharitonova MV,Kravchenko MS,Zheltova AA

    更新日期:2011-07-01 00:00:00

  • Effect of succinic acid and tween-80 on glucuronidation of 2-ethyl-6-methyl-3-hydroxypyridine.

    abstract::We studied the effect of succinic acid on the process of glucuronidation of 2-ethyl-6-methyl-3-hydroxypyridine after peroral and intraperitoneal administration in the form of succinate or a base. Since the basic form of 2-ethyl-6-methyl-3-hydroxypyridine is insoluble in water, it was administered in 5% Tween-80. It wa...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-008-0205-4

    authors: Baranov PA,Kravtsova OU,Sariev AK,Sherdev VP

    更新日期:2008-07-01 00:00:00

  • Autoantibodies to neuron-specific proteins S100, GFAP, MBP and NGF in the serum of rats with streptozotocin-induced diabetes.

    abstract::The appearance of autoantibodies to neuronal proteins (S100, GFAP, MBP, and NGF) in rat serum was analyzed by ELISA on days 5, 10, 17, 25, and 32 after streptozotocin injection. Simultaneously, blood glucose and insulin autoantibodies were assayed. Serum glucose level increased on the next day after streptozotocin inj...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-013-2077-5

    authors: Lotosh NG,Savel'eva EK,Selishcheva AA,Savel'ev SV

    更新日期:2013-05-01 00:00:00

  • Inotropic response of the myocardium in rats with postinfarction cardiosclerosis exposed to extrasystolic treatment.

    abstract::The inotropic response of the myocardium to extrasystolic treatment was studied on isolated perfused papillary muscles from rats with postinfarction cardiosclerosis. The development of postinfarction cardiosclerosis was accompanied by a decrease in myocardial excitability. The amplitude of extrasystolic contractions i...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-005-0367-2

    authors: Kondrat'eva DS,Afanas'ev SA,Falaleeva LP,Shakhov VP

    更新日期:2005-06-01 00:00:00

  • Role of NF-κB, PI3K, MAPK/ERK 1/2, and p38 in Erythropoietin Production by Bone Marrow Nuclears under Conditions of Immobilization Stress.

    abstract::The involvement of the studied signal cascades in the regulation of erythropoietin production by bone marrow nuclears under conditions of immobilization stress depends on the type of the hemopoiesis-inducing microenvironment cells and the period of blood system reaction to stress exposure. Secretory activity of monocy...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-017-3802-2

    authors: Miroshnichenko LA,Zhdanov VV,Udut EV,Polyakova TY,Zyuz'kov GN,Simanina EV,Sherstoboev EY,Stavrova LA,Agafonov VI,Minakova MY,Chaikovskii AV,Dygai AM

    更新日期:2017-07-01 00:00:00

  • Immunohistochemical Phenotypes of Stable and Unstable Occlusive Atherosclerotic Plaques in Coronary Arteries.

    abstract::We performed a complex morphological analysis of atherosclerotic plaques obtained from 68 men with coronary atherosclerosis during coronary bypass surgery with endarterectomy. The expression of MMP-2 and MMP-9, collagen IV, CD31, CD34, factor VIII, and of smooth muscle cell actin was measured in the samples by morphom...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-018-4268-6

    authors: Murashov IS,Volkov AM,Kazanskaya GM,Kliver EE,Savchenko SV,Klochkova SV,Lushnikova EL

    更新日期:2018-10-01 00:00:00

  • Association of Polymorphisms in Innate Immunity Genes TLR9 and DEFB1 with Human Longevity.

    abstract::The distribution of polymorphic variants of innate immunity genes TLR9 (+2848G>A) and DEFB1(-20G>A; -44C>G; -52G>A) was evaluated in long-living individuals. No significant differences were found in the distribution of genotypes and alleles of the TLR9 gene. The following features were revealed: increase in the freque...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-015-2894-9

    authors: Gankovskaya LV,Svitich OA,Artem'eva OV,Miroshnichenkova AM,Rusanova KV

    更新日期:2015-05-01 00:00:00

  • Multidimensional assessment of differences in monoamine metabolism in C57BL/6 and BALB/c mice.

    abstract::Monoamine metabolism in the hypothalamus and striatum of BALB/c and C57Bl/6 mice (intact and stressed in the open field test) was studied using single- and multidimensional statistical methods. It is suggested that the revealed difference in neurotransmitter metabolism is associated with genetically controlled behavio...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/BF02439811

    authors: Seredenin SB,Lapitskaya AS,Nadorov SA,Kudrin VS,Badyshtov BA

    更新日期:2000-05-01 00:00:00

  • Effect of plasma lipoproteins and their complexes with polysaccharides on interleukin-1beta concentration in macrophages of mice with HA-1 ascitic hepatoma.

    abstract::Experiments on cultured peritoneal macrophage from mice with HA-1 ascitic hepatoma showed that plasma lipoproteins present in the incubation medium decreased intracellular concentration of interleukin-1beta. These changes were most pronounced for high-density lipoproteins (alone or in combination with cortisol). Bacte...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-009-0557-4

    authors: Polyakov LM,Sumenkova DV,Panin LE

    更新日期:2009-04-01 00:00:00