Abstract:
:The peculiarities of Walker 256 tumor growth depending on the dose of transplanted cells were studied in rats differing by vasopressin production. Transplantation of 10(5) cells does not lead to tumor development. The dose of 7 x 10(5) cells induces progressively growing tumors in WAG rats, while in Brattleboro rats tumors regressed after a short period of growth. Increasing the dose to 2.8 x 10(6) cells was inessential for the dynamics of tumor growth in WAG rats, but stimulated regression of tumor growth in Brattleboro rats, producing no vasopressin. This dose dependence suggests the involvement of the immune system into the dynamics of tumor growth.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Khegay II,Popova NA,Ganilova LS,Shnyder EP,Ivanova LNdoi
10.1007/s10517-008-0001-1subject
Has Abstractpub_date
2008-01-01 00:00:00pages
81-3issue
1eissn
0007-4888issn
1573-8221journal_volume
145pub_type
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