Abstract：
:An open comparative clinical study evaluated the efficiency of Proproten-100 in reliving affective, somatovegetative, behavioral, and cognitive post-withdrawal disorders and manifestations of primary pathological alcohol addiction in patients with alcohol dependence in the stage of therapeutic remission. We compared the efficiency of Proproten-100 and standard symptomatic drugs. The preparation possessed anxiolytic, antidepressant, and vegetostabilizing properties, produced a moderate soporific effect, and had no sedative activity in patients with dysphoric depressions and psychopathic disorders. Proproten-100 was more effective during the therapy of patients with anxious and wistful depressions. Proproten-100 increased the contents of IgG and natural antibodies against S100 protein in the blood from patients. The preparation did not cause side effect or development of tolerance. Proproten-100 has psychotropic properties and holds much promise for long-term treatment of patients with alcohol dependence to reduce the incidence of recurrences.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Bokhan NA,Abolonin AF,Krylov EN,Vetlugina TP,Ivanova SA,Epstein OIdoi
10.1023/a:1024709014483subject
Has Abstractpub_date
2003-01-01 00:00:00pages
171-5eissn
0007-4888issn
1573-8221journal_volume
135 Suppl 7pub_type
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