Catecholamines and their metabolites in the brain and urine of rats with experimental Parkinson's disease.

abstract：:Low-dose (250 mg daily) oral probucol produces a significant antioxidant effect in coronary patients: increases activity of glutathione peroxidase (enzyme utilizing lipoperoxides) and reduces the content of free-radical oxidation products in the blood. Probucol therapy for 7 days before and for 6 months after coronary...

journal_title：Bulletin of experimental biology and medicine

authors： Kaminnyi AI,Lankin VZ,Perepelitsa EI,Konovalova GG,Samko AN,Tikhaze AK,Kukharchuk VV,Belenkov YN

更新日期：2007-11-01 00:00:00

abstract：:Hemopoietic islets, associations of stromal (macrophages, fibroblasts) and blood (including stem) cells, are structural and functional units of the bone marrow. We studied cellular and molecular processes developing following short-term (1 h) contact of hemopoietic islets with ferromagnetic nanoparticles in a multicel...

journal_title：Bulletin of experimental biology and medicine

authors： Novitsky VA,Khlusov IA,Ryazantseva NV,Chechina OE,Feduschak TA,Ermakov AE,Uimin MA

更新日期：2011-08-01 00:00:00

abstract：:Function of sarcoplasmic reticulum was studied in rat papillary muscles treated with amiodarone. An extra stimulus (0.5 Hz) was delivered to the muscle 0.225 sec after application of a regular stimulus. Postextrasystolic potentiation was evaluated in control myocardial samples and samples treated with amiodarone. The ...

journal_title：Bulletin of experimental biology and medicine

authors： Afanas'ev SA,Lukavskaya IA,Kandinskii ML,Medvedev MA

更新日期：2002-03-01 00:00:00

abstract：:Silicon crystal 2-5 nm nanoparticles in the form of 1-5-μ granules in water suspension were injected intraperitoneally in a single dose to male F(1)(CBA×C57Bl/6) mice or to outbred albino rats on days 1, 7, and 14 of gestation. Silicon crystal nanoparticles in doses of 5, 25, and 50 mg/kg exhibited no cytogenetic acti...

journal_title：Bulletin of experimental biology and medicine

authors： Durnev AD,Solomina AS,Daugel-Dauge NO,Zhanataev AK,Shreder ED,Nemova EP,Shreder OV,Veligura VA,Osminkina LA,Timoshenko VY,Seredenin SB

更新日期：2010-10-01 00:00:00

abstract：:We studied the effects of a concentrate of metabolites of Trichoderma harzianum Rifai F-180, an active producer of L-lysine-α-oxidase, and homogenous enzyme on a highly virulent bacteria Erwinia amylovora. The producer of antitumor and antiviral Trichoderma enzyme L-lysine-α-oxidase was cultured on a processing system...

journal_title：Bulletin of experimental biology and medicine

authors： Smirnova IP,Karimova EV,Shneider YA

更新日期：2017-10-01 00:00:00

abstract：:The effects of fullerene C(60) nanocomposites on human platelet aggregation induced by ADP, ristocetin, and collagen were studied. The nanocomposite containing fullerene C(60) in polyvinyl pyrrolidone solution did not change platelet aggregation, while fullerene C(60) in crown ether and Twin-80 solutions inhibited ADP...

journal_title：Bulletin of experimental biology and medicine

authors： Vaschenko VI,Samonin VV,Popov VA,Antonenkova EV,Nikonova VJ,Vilyaninov VN,Podvjaznikov ML,Kidalov VN,Titulova TB,Vaschenko TN

更新日期：2012-03-01 00:00:00

abstract：:Individual or combined administration of BCG vaccine and silicon dioxide to male mice induced a nonspecific stress response of the adrenal glands and gonads judging from changes in the concentration of blood cortisol and testosterone. The dynamics of cortisol concentration in the adrenal glands was similar, while chan...

journal_title：Bulletin of experimental biology and medicine

authors： Palchikova NA,Kuzminova OI,Utkina NV,Selyatitskaya VG,Shkurupiy VA

更新日期：2008-12-01 00:00:00

abstract：:The effects of ladasten and reference product imipramine (10 mg/kg) on the content of cytokines TNF-α, IL-6, IL-10, IL-1α, IL-2, IL-4, IL-5, IL-17, IFN-γ, and GM-CSF and behavior of male C57Bl/6 mice were studied on the model of a depression-like state induced by a single intraperitoneal injection of bacterial LPS in ...

journal_title：Bulletin of experimental biology and medicine

authors： Tallerova AV,Kovalenko LP,Durnev AD,Seredenin SB

更新日期：2011-11-01 00:00:00

abstract：:We studied the effect of 10-week treatment with intranasal insulin (0.5 IU/day) on glucose tolerance, glucose utilization, lipid metabolism, functions of pancreatic β cells, and insulin system in the liver of rats with cafeteria diet-induced metabolic syndrome. The therapy reduced body weight and blood levels of insul...

journal_title：Bulletin of experimental biology and medicine

authors： Derkach KV,Ivantsov AO,Chistyakova OV,Sukhov IB,Buzanakov DM,Kulikova AA,Shpakov AO

更新日期：2017-06-01 00:00:00

abstract：:Intraperitoneal administration of substance S-1 to male Wistar rats with impaired hearing markedly increased hearing acuity. Substance S-1 had no negative effects on hearing in intact animals. ...

journal_title：Bulletin of experimental biology and medicine

authors： Shestakova EV

更新日期：2002-01-01 00:00:00

abstract：:We revealed some relationships between the level of orientation and exploratory behavior, functional activity of the immune system, and structural and functional organization of the CNS in animals. Significant differences in brain morphology and expression of cytokine IL-1 beta, type I IL-1 receptor, and erythropoieti...

journal_title：Bulletin of experimental biology and medicine

authors： Markova EV,Chernova TG,Fillimonov PN,Korotkova NA,Abramov VV,Kozlov VA

更新日期：2004-10-01 00:00:00

abstract：:We demonstrated the influence of short peptides on the expression of signaling molecules in organotypic culture of the pineal gland from 3-month-old rats. Peptides Ala-Glu-Asp-Gly and Lys-Glu-Asp stimulate the expression of proliferative protein Ki-67 in pineal gland culture. These peptides as well as Glu-Asp-Arg and ...

journal_title：Bulletin of experimental biology and medicine

authors： Khavinson VKh,Linkova NS,Chalisova NI,Dudkov AV,Koncevaya EA

更新日期：2011-11-01 00:00:00

abstract：:Infection of surfagon (gonadotropin-releasing hormone analog) in a dose of 0.1 microg/kg to male CBA mice stimulated lymphocyte migration from splenic B zones, caused moderate thinning of the thymic cortex, thickening of the zona fasciculata of the adrenal cortex with signs of corticocyte activation. After administrat...

journal_title：Bulletin of experimental biology and medicine

authors： Bobyntsev II,Dolzhikov AA,Severyanova LA

更新日期：2005-01-01 00:00:00

abstract：:The content of MMP-8 and MMP-9 in oral fluid of 145 patients (95 women and 50 men, 18-52 years) was measured by enzyme immunoassay. We examined 63 subjects with the intact periodontium and 82 patients with chronic generalized periodontitis (25 patients with mild disease, 45 patients with moderate disease, and 12 patie...

journal_title：Bulletin of experimental biology and medicine

authors： Kushlinskii NE,Solovykh EA,Karaoglanova TB,Bayar U,Gershtein ES,Troshin AA,Kostyleva OI,Grinin VM,Maksimovskaya LN,Yanushevitch OO

更新日期：2011-12-01 00:00:00

abstract：:Cytochemical activity of succinate dehydrogenase and lactate dehydrogenase in blood lymphocytes, activity of hydroperoxides, MDA, and blood plasma antioxidants were studied in experimental animals during immobilization stress after preliminary injection of doxazosin. Preliminary adrenergic receptor blockade prevented ...

journal_title：Bulletin of experimental biology and medicine

authors： Vishnevskii EL,Vishnevskii AE,Shabel'nikova EI,Safronova ON,Dreval AA,Topchieva GV,Sukhorukov VS

更新日期：2004-11-01 00:00:00

abstract：:We studied a combined effect of subcomponents of vitamin B complex on the growth, development, and death of human embryonic brain-derived cells (E90) cultured using a modified method of Matson. Cell death was detected by trypan blue staining. According to our results, vitamin B-complex in low-doses promote the develop...

journal_title：Bulletin of experimental biology and medicine

authors： Danielyan KE,Abramyan RA,Galoyan AA,Kevorkian GA

更新日期：2011-09-01 00:00:00

abstract：:We studied in vitro cytostatic effect of doxorubicin on bone marrow cells preincubated with NAD and reduced glutathione. The presence of NAD and glutathione in the medium potentiated membrane toxicity of this antibiotic, but prevented its toxic effects on intracellular pool of pyridine nucleotides during oxidative str...

journal_title：Bulletin of experimental biology and medicine

authors： Egorova AB,Uspenskaya YA,Nefedov VP

更新日期：2001-07-01 00:00:00

abstract：:Ten-minute perfusion of intact isolated rat heart with Krebs-Henseleit solution containing delta-opioid receptor agonists (DPDPE, (-)-TAN-67) or delta-opioid receptor antagonists (naltrindole, TIPP[psi], ICI 174,864) at a final concentration of 0.1 mg/liter decreased HR, blood pressure in the left ventricle, and the r...

journal_title：Bulletin of experimental biology and medicine

authors： Maslov LN,Lishmanov YB,Barzakh EI,Lasukova TV,Rice KK,Oeltgen PR

更新日期：2006-04-01 00:00:00

abstract：:Antioxidant properties of recombinant peroxiredoxin-6 and chimeric protein PSH combining peroxidase and superoxide dismutase activities were studied on the model of retrograde perfusion of isolated rat heart under conditions of H2O2-induced oxidative stress. The exogenous antioxidant proteins exhibited cardioprotectiv...

journal_title：Bulletin of experimental biology and medicine

authors： Karaduleva EV,Mubarakshina EK,Sharapov MG,Volkova AE,Pimenov OY,Ravin VK,Kokoz YM,Novoselov VI

更新日期：2016-03-01 00:00:00

abstract：:Preparation containing ultralow doses of antibodies to stem cell factor considerably activates bone marrow myelopoiesis suppressed by cyclophosphamide. This effect of the preparation is based on stimulation of proliferation of committed hemopoietic precursors and increase in functional activity of adherent elements of...

journal_title：Bulletin of experimental biology and medicine

authors： Stavrova LA,Zyuz'kov GN,Simanina EV,Miroshnichenko LA,Udut EV,Khrichkova TY,Skurikhin EG,Pershina OV,Ermakova NN,Firsova TV,Zhdanov VV,Dygai AM,Gol'dberg ED

更新日期：2009-09-01 00:00:00

abstract：:The development of MPTP-induced depressive syndrome in rats was accompanied by activation of prolyl endopeptidase and dipeptidyl peptidase IV in the brain frontal cortex. Prolyl endopeptidase activity in the striatum also increased under these conditions. Our results indicate that proline-specific peptidases in the ta...

journal_title：Bulletin of experimental biology and medicine

authors： Krupina NA,Zolotov NN,Bogdanova NG,Orlova IN,Khlebnikova NN,Kryzhanovskii GN

更新日期：2006-11-01 00:00:00

abstract：:The paper analyzes theoretical models of the adaptive modes of generation and stability of human heart as a nonlinear point source. The analysis encompasses only ECG time-domain dynamics. To solve the general problem of the study of the adaptive changes of the cardiosignal under the action of external periodic force a...

journal_title：Bulletin of experimental biology and medicine

authors： Pipin VV,Ragulskaya MV,Chibisov SM

更新日期：2010-10-01 00:00:00

abstract：:We studied ultrastructure of nuclear compartment in cardiomyocytes during regenerative and plastic insufficiency of the myocardium induced by anthracycline antibiotic daunomycin. A peculiarity of ultrastructural organization of cardiomyocyte nuclei under these conditions is almost complete disappearance of the heteroc...

journal_title：Bulletin of experimental biology and medicine

authors： Nepomnyashchikh LM,Lushnikova EL,Semenov DE

更新日期：2000-12-01 00:00:00

abstract：:Isolated perfused rat heart was subjected to global ischemia (45 min) followed by reperfusion (30 min). Under these conditions, the level of creatine phosphokinase in the perfusate increased by 4.5 times. Perfusion (10 min) of the isolated heart with a solution containing cannabinoid HU-210 (0.1 or 1.0 μmol/liter) was...

journal_title：Bulletin of experimental biology and medicine

authors： Maslov LN,Krylatov AV,Lishmanov YB

更新日期：2014-09-01 00:00:00

abstract：:Comparative analysis of the parameters of LPO, antioxidant defense (AOD), and the thiol/disulfide system was performed in fertile and infertile males of reproductive age carrying different genotypes of the glutathione system genes. Blood plasma, blood hemolysate, and ejaculate served as specimens for biochemical studi...

journal_title：Bulletin of experimental biology and medicine

authors： Kolesnikova LI,Kurashova NA,Bairova TA,Dolgikh MI,Ershova OA,Natyaganova LV,Dashiev BG,Gutnik IN,Koroleva NV

更新日期：2017-07-01 00:00:00

abstract：:Homocysteine and homocysteic acid increased the stationary level of reactive oxygen species in rat lymphocytes, homocysteic acid being more potent in this respect. The effect of this compound was realized via ionotropic NMDA receptors and group III metabotropic glutamate receptors. Incubation of lymphocytes with homoc...

journal_title：Bulletin of experimental biology and medicine

authors： Vladychenskaya EA,Tyulina OV,Boldyrev AA

更新日期：2006-07-01 00:00:00

abstract：:Manifestations of hunger and satiation in myoelectric activity patterns in different portions of the stomach were studied in chronic experiments. The state of hunger manifested in the structure of temporal organization of slow electric activity of muscles in the stomach body and antrum in the form of bimodal distribut...

journal_title：Bulletin of experimental biology and medicine

authors： Kromin AA,Zenina OY

更新日期：2012-11-01 00:00:00

abstract：:Fluorescent granular cells of the thymus lobule containing neurotransmitter monoamines express Ia antigen and S-100 protein, which attests to their macrophage origin; positive staining with aldehyde fuchsin points to secretion of peptide hormones by these cells. These facts and the absence of phagocytic activity allow...

journal_title：Bulletin of experimental biology and medicine

authors： Gordon DS,Sergeeva VE,Smorodchenko AT,Kirillov NA,Petrova TL,Olangin OI,Spirin IV

更新日期：2001-07-01 00:00:00

abstract：:Apoptosis of blood neutrophils from healthy donors was studied under conditions of cell culturing with different concentrations of H(2)O(2), selective NO synthase inhibitor, and inductor of NO synthesis (L-arginine). In vitro incubation of neutrophilic leukocytes with 5 mM H(2)O(2) led to activation of the apoptotic p...

journal_title：Bulletin of experimental biology and medicine

authors： Stepovaya YA,Zhavoronok TV,Starikov YV,Bychkov VA,Chasovskih NY,Starikova YG,Petina GV,Novitsky VV,Ryazantseva NV

更新日期：2008-12-01 00:00:00

abstract：:Digital simulation of disorders in the p53 and Mdm2 protein system, involved in repair of DNA defects and in many vital processes, including tumor formation, neurodegeneration, and aging, was carried out on the base of functional nonlinear octoparametric mathematical model. Stress situations were studied, associated w...

journal_title：Bulletin of experimental biology and medicine

authors： Voropaeva OF,Shokin YI,Nepomnyashchikh LM,Senchukova SR

更新日期：2014-08-01 00:00:00