Abstract：
:Isolated perfused rat heart was subjected to global ischemia (45 min) followed by reperfusion (30 min). Under these conditions, the level of creatine phosphokinase in the perfusate increased by 4.5 times. Perfusion (10 min) of the isolated heart with a solution containing cannabinoid HU-210 (0.1 or 1.0 μmol/liter) was followed by a 2-fold decrease in creatine phosphokinase level in the perfusate. The cardioprotective effect of HU-210 remained unchanged under condition of NO synthase inhibition. Cannabinoid HU-210 reduced the concentration of cAMP in the myocardium by 2 times during reperfusion, but did not affect it before and during ischemia. This agent also did not change the level of cGMP in the myocardium before and during ischemia and during reperfusion. The results of the experiment suggest that the cardioprotective effect of HU-210 can be determined by a decrease in cAMP level in the myocardium during reperfusion. cGMP and NO synthase do not contribute to cytoprotective effect of HU-210.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Maslov LN,Krylatov AV,Lishmanov YBdoi
10.1007/s10517-014-2622-xsubject
Has Abstractpub_date
2014-09-01 00:00:00pages
588-91issue
5eissn
0007-4888issn
1573-8221journal_volume
157pub_type
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