Abstract:
:During exacerbation of cytomegalovirus infection during pregnancy, cytomegalovirus proteins penetrate across the external membrane of placental villous syncytiotrophoblast and suppress activities of ATPase and Bcl-2 protein. Simultaneous increase in the content of annexin V and caspase 3 leads to structural disturbances in DNA in syncytiotrophoblast nuclei and stimulates their apoptosis. Structural abnormalities in the syncytiotrophoblast during exacerbation of cytomegalovirus infection are dangerous for fetal development.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Lutsenko MT,Andrievskaya IAdoi
10.1007/s10517-016-3162-3subject
Has Abstractpub_date
2016-01-01 00:00:00pages
327-9issue
3eissn
0007-4888issn
1573-8221pii
10.1007/s10517-016-3162-3journal_volume
160pub_type
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