Abstract:
:Function of sarcoplasmic reticulum was studied in rat papillary muscles treated with amiodarone. An extra stimulus (0.5 Hz) was delivered to the muscle 0.225 sec after application of a regular stimulus. Postextrasystolic potentiation was evaluated in control myocardial samples and samples treated with amiodarone. The preparation significantly increased all the parameters of postextrasystolic contraction. It was concluded that amiodarone potentiates the ability of sarcoplasmic reticulum to accumulate Ca2+ ions.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Afanas'ev SA,Lukavskaya IA,Kandinskii ML,Medvedev MAdoi
10.1023/a:1015832710818subject
Has Abstractpub_date
2002-03-01 00:00:00pages
205-7issue
3eissn
0007-4888issn
1573-8221journal_volume
133pub_type
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