Effect of amiodarone on functional state of sarcoplasmic reticulum in rat myocardium.

Abstract:

:Function of sarcoplasmic reticulum was studied in rat papillary muscles treated with amiodarone. An extra stimulus (0.5 Hz) was delivered to the muscle 0.225 sec after application of a regular stimulus. Postextrasystolic potentiation was evaluated in control myocardial samples and samples treated with amiodarone. The preparation significantly increased all the parameters of postextrasystolic contraction. It was concluded that amiodarone potentiates the ability of sarcoplasmic reticulum to accumulate Ca2+ ions.

journal_name

Bull Exp Biol Med

authors

Afanas'ev SA,Lukavskaya IA,Kandinskii ML,Medvedev MA

doi

10.1023/a:1015832710818

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

205-7

issue

3

eissn

0007-4888

issn

1573-8221

journal_volume

133

pub_type

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