Abstract:
:Integral activity of neutral deoxyribonucleases in the plasma and urine or donors, patients with benign prostatic hyperplasia, and patients with stomach and prostatic cancer was studied by IFA based on hydrolysis of DNA fragment modified with haptene molecules. In donors plasma deoxyribonuclease activity was 0.16+/-0.04, urinary activity 1.49+/-1.41 act. U/ml. In patients with benign prostatic hyperplasia and malignant tumors the integral activity of blood deoxyribonucleases was significantly below the normal, and in tumors it did not correlate with tumor size and disease stage. A significant correlation between blood and urinary deoxyribonuclease activities was detected.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Tamkovich SN,Cherepanova AV,Bryzgunova OE,Kolesnikova EV,Permyakova VI,Vlassov VV,Laktionov PPdoi
10.1007/s10517-008-0213-4subject
Has Abstractpub_date
2008-07-01 00:00:00pages
89-91issue
1eissn
0007-4888issn
1573-8221pii
doijournal_volume
146pub_type
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