Abstract:
:We measured activity of angiotensin-converting enzyme in plasma and tissue of NISAG and normotensive WAG rats. In different organs of NISAG rats, activity of this enzyme did not differ from the corresponding values of WAG rats, although enzyme activity in the plasma of NISAG rats was significantly lower than that of WAG rats. Since NISAG rats are characterized by low activity of renin in the renal cortex, it is hypothesized that NISAG rats simulate the low-renin hypertension, in which inhibition of activity of the angiotensin-production system results from elevation of arterial pressure of central origin.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Cherkasova OP,Fedorov VI,Markel ALdoi
10.1007/s10517-005-0498-5subject
Has Abstractpub_date
2005-10-01 00:00:00pages
388-90issue
4eissn
0007-4888issn
1573-8221journal_volume
140pub_type
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