Abstract：
:We studied the effect of μ-opioid receptor ligands on anxious and depressive behavior of rats. Intragastric administration of loperamide and methylnaloxone reduced animal anxiety evaluated by an increase in the number of entries into and time spent in open arms of the elevated plus-maze. μ-Opioid receptor agonist loperamide had the most pronounced anxiolytic effect. Analysis of animal behavior in the forced swimming test showed that administration of μ-opioid receptor antagonist methylnaloxone reduced the latency of the first submersion, increased the total time of submersion episodes, and shortened the time of active swimming, which attested to depressive properties of this agent. Loperamide had little effect on behavior of rats in the forced swimming test. Thus, μ-opioid receptor agonist loperamide has the antianxiety properties and produced no sedative effect. Therefore, this agent holds much promise as an anxiolytic drug.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Sudakov SK,Bashkatova VG,Kolpakov AA,Trigub MMdoi
10.1007/s10517-010-0925-0subject
Has Abstractpub_date
2010-09-01 00:00:00pages
273-5issue
3eissn
0007-4888issn
1573-8221journal_volume
149pub_type
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