Heart Rhythm Disturbances Caused by Injection of Cholinesterase Inhibitor Physostigmine to Rats during the Early Ontogeny.

Abstract:

:Parameters of cardiac activity after administration of the cholinesterase inhibitor physostigmine were analyzed in newborn rats and on day 16 of postnatal development. The type of cardiovascular response to acetylcholine excess in newborns and 16-day-old rats were similar, but they significantly differed by the magnitude, which suggests that that maturation of cholinergic structures involved in the regulation of cardiac activity is completed during the early postnatal ontogeny.

journal_name

Bull Exp Biol Med

authors

Sizonov VА,Dmitrieva LE

doi

10.1007/s10517-018-4095-9

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

44-47

issue

1

eissn

0007-4888

issn

1573-8221

pii

10.1007/s10517-018-4095-9

journal_volume

165

pub_type

杂志文章
  • Regulation of proteolytic activity of pepsin in rats [correction of mice] by rotating electromagnetic field.

    abstract::In experiments on Wistar rats we studied the effect of low-frequency electromagnetic field rotating in either right-handed or a left-handed sense on proteolytic activity of pepsin. The right-handed rotating field increased, while left-handed rotating field decreased pepsin activity. Possible mechanisms of these change...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-005-0281-7

    authors: Subbotina TI,Khadartsev AA,Yashin MA,Yashin AA

    更新日期:2005-03-01 00:00:00

  • Pathomorphological and immunohistochemical analysis biopsy specimens from large bronchi of patients with pulmonary cancer.

    abstract::Biopsy specimens from large bronchi of patients with central and peripheral pulmonary cancer were studied. Central cancer was associated with hyperplasia and dysplasia of the epithelium, hyperplasia of glandular compartment, and pronounced immunocompetent cell response. Peripheral cancer was characterized by predomina...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1021108920079

    authors: Nepomnyashchikh GI,Levitskii VA,Dolgovykh AK,Naumova LA

    更新日期:2002-08-01 00:00:00

  • The connective tissue in local therapy of experimental arthritis with miacalcic.

    abstract::Effects of local therapy with miacalcic on the metabolism in articular connective tissue structures under conditions of experimental arthritis are shown. An effect modifying articular tissue metabolism and an antiinflammatory effect preventing the development of inflammatory destructive processes in rabbit articular t...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-007-0108-9

    authors: Belova SV

    更新日期:2007-03-01 00:00:00

  • Oxygen-dependent processes in monocytes and metabolic risk factors for atherogenesis.

    abstract::Oxygen-dependent processes in peripheral blood monocytes were intensified in patients with metabolic cardiovascular syndrome. This was manifested in increased production of O(2)(*-) and NO. Among metabolic factors (cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triacylglycerols...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/b:bebm.0000038145.39332.85

    authors: Suslova TE,Gruzdeva OV,Fedorova TS,Karpov RS

    更新日期:2004-05-01 00:00:00

  • Expression of beta-Secretase mRNA in the brain of rats with immunohistochemical destruction of basal forebrain cholinergic system.

    abstract::We studied properties of cloned BACE mRNA (beta-site of the enzyme cleaving amyloid precursor protein) and evaluated the possibility of using this clone for identification and/or prediction of neurodegenerative disorders associated with cholinergic deficiency. Wistar rats subjected to immunohistochemical destruction o...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1021564231603

    authors: Lushchekina EA,Bigl M,Apelt J,Lange-Dohna C,Rossner S,Schliebs R

    更新日期:2002-09-01 00:00:00

  • Modulating effect of interleukin-4 on free radical processes in the brain of rats during emotional stress.

    abstract::We studied the effect of anti-inflammatory cytokine IL-4 on the intensity of free radical processes in emotiogenic brain structures (hypothalamus, sensorimotor cortex, and amygdala) in rats with different prognostic emotional resistance. One-hour immobilization of animals with simultaneous electrocutaneous stimulation...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-011-1340-x

    authors: Pertsov SS,Koplik EV,Kalinichenko LS

    更新日期:2011-08-01 00:00:00

  • Human Diploid Fibroblast Cell Lines - a Model System for Studying Immunodulatory Properties of Modern Immunobiological Drugs and Viruses.

    abstract::The immunomodulatory properties of immunobiological drugs Glutoxim and Phosprenyl we well as vesicular stomatitis virus and inactivated tick-borne encephalitis vaccine virus were studied using human diploid fibroblast cell line from the collection of M. P. Chumakov Federal Research Center for Research and Development ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-020-05037-8

    authors: Konyuschko OI,Ozherelkov SV,Vorovich MF,Ivanova AL,Sotskova SE,Ishmuhametov AA,Kozhevnikova TN,Sanin AV

    更新日期:2020-12-01 00:00:00

  • Role of MEK, PI3, p38, Tyrosine, and mTOR Kinases in Regulation of Heart Resistance to the Arrhythmogenic Action of Short-Term Ischemia and Reperfusion.

    abstract::MEK, PI3, p38, tyrosine, and mTOR kinases are not involved in the regulation of heart resistance to the arrhythmogenic action of short-term ischemia/reperfusion in non-adapted rats. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-015-2848-2

    authors: Maslov LN,Mukhomedzyanov AV,Tsibulnikov SY,Chauski EI,Khaliulin IG,Portnichenko AG

    更新日期:2015-04-01 00:00:00

  • Genetic variability of enterobacterial resistant integrons.

    abstract::Sulfamide-resistant (SulR) natural strains of enterobacteria (11.9% of a total of 797 cultures, isolated with enteric microflora of honeybee gut, bee-fermented pollen, and plant issues) were tested for class 1 antibiotic resistance integrons (MRI). Only 5.3% of SulR strains were MRI-positive. Mutability of weak (wild ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-011-1397-6

    authors: Solomenny AP,Lyapunov YE,Kuzyaev RZ

    更新日期:2011-09-01 00:00:00

  • Possible role of slow sodium-calcium channels in the mechanism of changes in electrical and mechanical activity of guinea pig heart cells in local anaphylaxis (the isoptine effects).

    abstract::The local anaphylactic reaction and the effects of histamine during blocking of the slow sodium-calcium channels by isoptine were investigated in the spontaneously contracting oracle of the atrium of a guinea pig previously sensitized to egg albumin. Simultaneously with the intracellular recording of the potentials, i...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/BF00799305

    authors: Khodorov BI,Voronovitskii EG,Ignat'eva VB

    更新日期:1975-01-01 00:00:00

  • Antiarrhythmic and arrhythmogenic effects of L-carnitine in ischemia and reperfusion.

    abstract::Isolated rat hearts were subjected to 30-min coronary artery occlusion followed by 120-min reperfusion. The hearts (n=8-12) were perfused with Krebs-Henseleit solution enriched with L-carnitine (0.5, 2.5 and 5 mM) for 10 min before and after ischemia or reperfusion and for the whole period of ischemia and reperfusion....

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-008-0249-5

    authors: Najafi M,Garjani A,Maleki N,Eteraf Oskouei T

    更新日期:2008-08-01 00:00:00

  • Effect of photodynamic therapy with photodithazine on morphofunctional parameters of M-1 sarcoma.

    abstract::Efficiency and mechanisms of action of photodynamic therapy of M-1 sarcoma were studied experimentally on rats using photodithazine, a novel chlorine photosensitizer. The tissue and cellular targets for this agent are vascular wall, plasma membrane of tumor cells, and intracellular structures responsible for prolifera...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-005-0133-5

    authors: Romanko YS,Tsyb AF,Kaplan MA,Popuchiev VV

    更新日期:2004-12-01 00:00:00

  • Peculiarities of autonomic regulation assessed by variability of hemodynamic parameters in rats with different stress resistance.

    abstract::Analysis of contribution of sympathetic and parasympathetic systems into heart rate variability carried out using atenolol and atropine showed that August rats are characterized by enhanced tone of the sympathetic system and reduced tone of the parasympathetic system compared to Wistar rats. Reduced tone of the parasy...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-006-0375-x

    authors: Kirillina TN,Usacheva MA,Belkina LM

    更新日期:2006-10-01 00:00:00

  • Ultrastructural study of cell populations in the gastric transplant after esophagoplasty.

    abstract::Ultrastructural characteristics of cell populations in the gastric tube mucosa were studied after plastic surgery for benign esophageal disease. The foveolar epithelium mainly consisted of secretory active mucocytes with small changes in cytoplasmic organelles. Functionally immature parietal cells and gland cells in t...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-011-1175-5

    authors: Lapii GA,Nepomnyashchikh LM,Sudovykh IE,Kutepov AV,Govorkov RV

    更新日期:2011-02-01 00:00:00

  • Effect of Coenzyme Q10 on Expression of UbiAd1 Gene in Rat Model of Local Cerebral Ischemia.

    abstract::The study examined the effect of endogenous lipid-soluble antioxidant coenzyme Q10 on the expression of UbiA gene of prenyltransferase domain-containing protein 1 (UbiAd1) involved in synthesis of vitamin K2 (and probably of coenzyme Q10) on a rat model of ischemic stroke provoked by ligation of the middle cerebral ar...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-018-4101-2

    authors: Povarova OV,Balatsky AV,Gusakov VS,Medvedev OS

    更新日期:2018-05-01 00:00:00

  • Detection of protein with anticonsolidation properties in the rat brain.

    abstract::Isolation and identification of rat brain protein regulated by serotonin-modulated protein SMP-69 is described. Intracerebral administration of anti-SMP-69 antibodies activates cerebral cortex cell genome and increases the content of electropheretic fraction 28. Intracerebral administration of isolated and purified pr...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/BF02766081

    authors: Mekhtiev AA

    更新日期:2000-08-01 00:00:00

  • Evaluation of the efficiency and safety of anaferon (pediatric formulation) in the treatment of chickenpox in children.

    abstract::Addition of anaferon (pediatric formulation) to the therapy of chickenpox patients led to more rapid disappearance of the main symptoms and alleviated the course of the disease. The safety of the preparation is confirmed by the absence of undesirable events and stability of laboratory indexes against the background of...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s10517-009-0698-5

    authors: Timchenko VN,Pavlova EB,Chernova TM,Bannova SL,Savel'eva TI,Tarasov SA,Kachanova MV,Siver'yanova MA

    更新日期:2009-08-01 00:00:00

  • Effect of platelet growth factors on proliferation of guinea pig bone marrow and splenic stromal precursor cells and proliferation of cultural descendants from bone marrow precursor cells.

    abstract::Elimination of platelets from guinea pig splenocyte suspension (lacking megakaryocytes) with EDTA considerable reduces the efficiency cloning of splenic stromal precursor cells. It means that platelet-derived growth factors are necessary for stromal precursor cells from different organs (bone marrow, thymus, and splee...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1015847019904

    authors: Gorskaya YF,Shuklina EY,Nesterenko VG

    更新日期:2002-03-01 00:00:00

  • A new method for express analysis of flavonoid fraction in nephrophite plant extract and prediction of its antioxidant effects.

    abstract::A new chromatographic procedure is proposed for rapid (35 min) complete fractionation of flavonoids in plant raw material; the method well discriminates between components with antioxidant activity (rutin, apigenin, quercetin, hesperidin). The method is based on reverse-phase high performance liquid chromatography usi...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-006-0273-2

    authors: Markaryan AA

    更新日期:2006-06-01 00:00:00

  • Inhibition of Histone Deacetylase 1 Prevents the Decrease in Titin (Connectin) Content and Development of Atrophy in Rat m. soleus after 3-Day Hindlimb Unloading.

    abstract::We studied the effect of histone deacetylase 1 (HDAC1) inhibition on titin content and expression of TTN gene in rat m. soleus after 3-day gravitational unloading. Male Wistar rats weighing 210±10 g were randomly divided into 3 groups: control, 3-day hindlimb suspension, and 3-day hindlimb suspension and injection of ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-020-04907-5

    authors: Ulanova AD,Gritsyna YV,Bobylev AG,Yakupova EI,Zhalimov VK,Belova SP,Mochalova EP,Nemirovskaya TL,Shenkman BS,Vikhlyantsev IM

    更新日期:2020-08-01 00:00:00

  • Comparative Study of Fusogenic Activity of H1 and H5 Subtypes Influenza Virus Hemagglutinins.

    abstract::Influenza virus hemagglutinins are surface proteins responsible for fusion of the viral and cellular membranes. Their capacity to mediate membrane fusion (fusogenic activity) is studied by various methods, including the syncytium formation and pseudovirus transduction methods. We constructed plasmids coding for genes ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-017-3930-8

    authors: Kononova AA,Cheresiz SV,Chechushkov AV,Razumova YV,Pokrovskii AG

    更新日期:2017-11-01 00:00:00

  • Comparison of the Levels of Transforming Growth Factor-β1 in Tear Fluid in Patients with High Myopia after Transepithelial Photorefractive Keratectomy and Laser Subepithelial Keratomileusis (LASEK).

    abstract::We compared the level of transforming growth factor-β1 (TGF-β1) in the tear fluid of 20 patients with high myopia who underwent transepithelial photorefractive keratectomy (T-PRK) in one eye and laser subepithelial keratomileusis (LASEK) in the contralateral eye. Tear fluid samples were collected with scaled microcapi...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-020-05008-z

    authors: Chen JJ,Yang YF,Zeng Y

    更新日期:2020-11-01 00:00:00

  • Photoprotective activity of melanin preparations from black yeast-like fungus during UV irradiation of human skin: dependence on the concentration.

    abstract::The effect of melanin solutions on the skin exposed to UV irradiation (1,050 kJ/m(2)) depended on its dose and varied from photoprotection (0.005 mg/ml) to photosensitization and phototoxicity (burn, 0.1 mg/ml). These results suggest that doses of melanin preparations should be empirically selected to achieve optimum ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1016254222805

    authors: Paramonov BA,Turkovskii II,Potokin IL,Chebotarev VY

    更新日期:2002-04-01 00:00:00

  • Myogenesis in hemopoietic tissue mesenchymal stem cell culture.

    abstract::The myogenic differentiation capacity of prenatal mesenchymal stem cells from the main sites of hemopoiesis (bone marrow, thymus, liver, and spleen) was studied. Myogenesis was observed in all studied cell cultures except splenic mesenchymal stem cells. Differentiating cells from the thymus, bone marrow, and liver wer...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-006-0208-y

    authors: Gornostaeva SN,Rzhaninova AA,Gol'dstein DV

    更新日期:2006-04-01 00:00:00

  • Endogenous progenitors as the source of cell material for ischemic damage repair in experimental myocardial infarction under conditions of changed concentration of vascular endothelial growth factor.

    abstract::We studied the effect of VEGF-A in experimental myocardial infarction on attraction of progenitor cells into the regeneration zone. The appearance of CD34(+)CD45(+) cells known as low-differentiated progenitor cells was observed in the damaged myocardial tissue in the presence of a considerable excess of VEGF-A. These...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-015-2801-4

    authors: Shurygin MG,Shurygina IA,Dremina NN,Kanya OV

    更新日期:2015-02-01 00:00:00

  • Reaction of rat tissues to implantation of lactic acid-based biodegradable polymer.

    abstract::Polylactide degradation processes after its implantation into the subcutaneous fat of rats were studied by microscopy. After implantation polylactide was encapsulated in connective tissue. If a fragment of polylactide had sharp edges, injuring the tissue, a thick capsule formed with pronounced inflammatory infiltratio...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-014-2473-5

    authors: Maiborodin IV,Kuznetsova IV,Beregovoi EA,Shevela AI,Barannik MI,Maiborodina VI,Manaev AA

    更新日期:2014-04-01 00:00:00

  • Some Peculiarities of Local Distribution of Multipotent Mesenchymal Stromal Cells after Their Injection into Intact Muscle Tissue in Experiment.

    abstract::Changes in the muscular tissue after subcutaneous injection of autologous bone marrow multipotent mesenchymal stromal cells transfected with GFP gene and additionally stained with cell membrane dye Vybrant CM-Dil in the projection of ligated femoral vein were studied by light microscopy with luminescence. Stromal cell...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-018-4031-z

    authors: Maiborodin IV,Morozov VV,Anikeev AA,Maslov RV,Figurenko NF,Matveeva VA,Maiborodina VI

    更新日期:2018-03-01 00:00:00

  • Structural and Functional State of Erythrocyte Membranes in Mice at Different Stages of Experimental Parkinson's Disease Induced by Administration of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP).

    abstract::We studied some structural and functional parameters of erythrocyte membranes in mice at the late presymptomatic and early symptomatic stages of experimental Parkinson's disease induced by administration of MPTP (hemolysis, microviscosity of different regions of the lipid bilayer, LPO intensity, activity of antioxidan...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-017-3666-5

    authors: Fatkullina LD,Molochkina EM,Kozachenko AI,Nagler LG,Burlakova EB

    更新日期:2017-03-01 00:00:00

  • hsa-miR-1973 MicroRNA is Significantly and Differentially Expressed in MDA-MB-231 Cells of Breast Adenocarcinoma and Xenografts Derived from the Tumor.

    abstract::The gene expression profiles of MDA-MB-231 cell line of breast cancer and xenografts derived from this tumor in murine model were analyzed using GeneChip Human Transcriptome array 2.0 platform (Affymetrix). A more than 1000-fold increase in the MIR1973 gene expression was observed in the xenografts compared to the ori...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-017-3873-0

    authors: Fomicheva KA,Knyazev EN,Mal'tseva DV

    更新日期:2017-09-01 00:00:00

  • Ligand-receptor assay for evaluation of functional activity of human recombinant VEGF and VEGFR-1 extracellular fragment.

    abstract::cDNA encoding VEGF and Ig-like extracellular domains 2-4 of VEGFR-1 (sFlt-1(2-4)) were cloned into prokaryotic expression vectors pET32a and pQE60. Recombinant proteins were purified (metal affinity chromatography) and renatured. Chemiluminescent study for the interaction of recombinant VEGF and sFlt-1(2-4) showed tha...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-012-1612-0

    authors: Leopol'd AV,Baklaushev VP,Korchagina AA,Shein SA,Grinenko NF,Pavlov KA,Ryabukhin IA,Chekhonin VP

    更新日期:2012-04-01 00:00:00