Role of MEK, PI3, p38, Tyrosine, and mTOR Kinases in Regulation of Heart Resistance to the Arrhythmogenic Action of Short-Term Ischemia and Reperfusion.

abstract：:GABA, baclofen, isoguvacine increase, and cis-4-aminocrotonic acid does not modify resting membrane potential of muscle cells. Bicuculline, phaclofen, N-ethylmaleimide, chlorpromazine, verapamil, and removal of Ca2+ from bathing solution abolished the effect of baclofen, while U73122 and D609 were ineffective in this ...

journal_title：Bulletin of experimental biology and medicine

authors： Volkov EM,Sabirova AR,Grishin SN,Zefirov AL

更新日期：2005-02-01 00:00:00

abstract：:The rates of oxyhemoglobin drop and CO(2) release in dogs with magnetized and nonmagnetized blood were compared. Stationary magnetic field enhances blood oxygen capacity by no less than 24%. A hypothesis was proposed on formation of bioxyhemoglobin molecules under the effect of magnetic field, in which hem binds two O...

journal_title：Bulletin of experimental biology and medicine

authors： Zhernovoi AI,Skorik VI,Chirukhin VA,Sharshina LM

更新日期：2001-02-01 00:00:00

abstract：:We studied the effect of allopregnanolone on stress-induced anxiety caused by intranasal administration of corticoliberin to male Wistar rats. Active and passive rats were selected by their T-maze behavior and then were tested in elevated plus maze for initial anxiety level. Basing on test results, the animals were di...

journal_title：Bulletin of experimental biology and medicine

authors： Semenova OG,Rakitskaya VV

更新日期：2014-04-01 00:00:00

abstract：:A simple method for the diagnosis of insulin resistance, easily realized in clinical practice, is developed in order to detect patients at a high risk of diseases associated with this condition. The metabolic index is estimated as the proportion of triglycerides and glucose values to quadratic HDL cholesterol value (i...

journal_title：Bulletin of experimental biology and medicine

authors： Roitberg GE,Dorosh ZhV,Sharkhun OO

更新日期：2015-01-01 00:00:00

abstract：:The effects of Biopin (ointment containing pine resin) used in the treatment of burns, wounds, and pyoinflammatory processes on cell composition of the wound surface (smears) and granulation tissue were studied on rats. In vitro antibacterial activity of the drug was also evaluated. At the early stage of inflammation ...

journal_title：Bulletin of experimental biology and medicine

authors： Simbirtsev AS,Konusova VG,Mchelidze GSh,Fidarov EZ,Paramonov BA,Chebotarev VY

更新日期：2002-05-01 00:00:00

abstract：:We studied the effects of selective delta-opiate receptor agonists and antagonists on the phosphoinositide pathway in lymphocytes from healthy donors and patients with diabetes mellitus. The test compounds probably play a role in changes in the sensitivity to pharmacological substances binding to delta-opiate receptor...

journal_title：Bulletin of experimental biology and medicine

authors： Agadjanov MI,Vartanian GS,Tadevosyan YV,Batikyan TB,Agadjanova EM

更新日期：2004-02-01 00:00:00

abstract：:Cell cultures isolated by the enzymatic method from the terminal placenta amnion consist mainly from epithelial cells, expressing cytokeratin-7, CD90, and CD73, are characterized by high viability and low proliferative potential. Adhesive cultures of umbilical (Wharton's jelly) cells, despite the fibroblast-like shape...

journal_title：Bulletin of experimental biology and medicine

authors： Rylova YV,Milovanova NV,Gordeeva MN,Savilova AM

更新日期：2015-06-01 00:00:00

abstract：:A composition containing culture medium conditioned by mesenchymal stem cells and mesenchymal stem cell lysate improves biochemical parameters, reduces inflammation, and stimulates regenerative processes in the liver. ...

journal_title：Bulletin of experimental biology and medicine

authors： Khubutiya MSh,Temnov AA,Vagabov VA,Sklifas AN,Rogov KA,Zhgutov YA

更新日期：2015-05-01 00:00:00

abstract：:Preclinical study of therapeutic properties of an innovative drug Doxorubicin-NPh (doxorubicin in the form of ultrafine suspension of phospholipid liposomes) in comparison with free doxorubicin (Doxorubicin-Teva) and protected doxorubicin (Caelyx) was performed on transplanted murine tumor models. All these drugs were...

journal_title：Bulletin of experimental biology and medicine

authors： Nemtsova ER,Tikhonova EG,Bezborodova OA,Pankratov AA,Venediktova JB,Korotkevich EI,Kostryukova LV,Tereshkina JA

更新日期：2020-10-01 00:00:00

abstract：:We compared the level of transforming growth factor-β1 (TGF-β1) in the tear fluid of 20 patients with high myopia who underwent transepithelial photorefractive keratectomy (T-PRK) in one eye and laser subepithelial keratomileusis (LASEK) in the contralateral eye. Tear fluid samples were collected with scaled microcapi...

journal_title：Bulletin of experimental biology and medicine

authors： Chen JJ,Yang YF,Zeng Y

更新日期：2020-11-01 00:00:00

abstract：:Comparative analysis of the parameters of LPO, antioxidant defense (AOD), and the thiol/disulfide system was performed in fertile and infertile males of reproductive age carrying different genotypes of the glutathione system genes. Blood plasma, blood hemolysate, and ejaculate served as specimens for biochemical studi...

journal_title：Bulletin of experimental biology and medicine

authors： Kolesnikova LI,Kurashova NA,Bairova TA,Dolgikh MI,Ershova OA,Natyaganova LV,Dashiev BG,Gutnik IN,Koroleva NV

更新日期：2017-07-01 00:00:00

abstract：:Penetration of titanium dioxide nanoparticles into enterocytes after their administration into isolated loop of rat small intestine was shown in vivo by transmission electron microscopy. Using electron diffraction, titanium dioxide nanoparticles were identified in the apical regions of the cells under plasma membranes...

journal_title：Bulletin of experimental biology and medicine

authors： Onishchenko GE,Erokhina MV,Abramchuk SS,Shaitan KV,Raspopov RV,Smirnova VV,Vasilevskaya LS,Gmoshinski IV,Kirpichnikov MP,Tutelyan VA

更新日期：2012-12-01 00:00:00

abstract：:Potential created by electrogenic ionic pumps under conditions of maximum activation in a warm standard ionic medium with K(+) after preincubation in cold potassium-free solution has two components: a higher ouabaine-insensitive "stationary" component, and a lower "regulatory" component sensitive to ouabaine, furosemi...

journal_title：Bulletin of experimental biology and medicine

authors： Volkov EM,Sabirova AR,Nurullin LF,Zefirov AL

更新日期：2006-12-01 00:00:00

abstract：:Systemic administration of ACTH to rats with normal hormone production induced a rapid (started 3 min postinjection) and long-term (persisted 30 min) elevation of pain threshold. Complete inhibition of glucocorticoid production shortened the duration of ACTH-induced analgesia to 15 min. The biphasic effect of ACTH on ...

journal_title：Bulletin of experimental biology and medicine

authors： Bogdanov AI,Yarushkina NI

更新日期：2001-03-01 00:00:00

abstract：:The content of biogenic amines and their metabolism in the ancient part of the amygdala (paleoamygdala) differ in male and female rats and depended on the phase of the estrous cycle. ...

journal_title：Bulletin of experimental biology and medicine

authors： Akhmadeev AV,Kalimullina LB

更新日期：2013-10-01 00:00:00

abstract：:Intravenous infection of chicken with H5N1 avian influenza virus (strain A/Gs/Krasnoozerskoye/627/05) causes rapid lethal outcome. Pathomorphological study of bird viscera showed manifestations of disseminated intravascular coagulation syndrome, generalized inflammatory reaction, and wide-scale necrobiotic changes in ...

journal_title：Bulletin of experimental biology and medicine

authors： Shestopalova LV,Shkurupiy VA,Sharkova TV,Shestopalov AM

更新日期：2008-12-01 00:00:00

abstract：:Pro-Gly-Pro and its metabolite Gly-Pro effectively prevented the development of erosive and ulcerative lesions of the gastric mucosa in rats under conditions of water-immersion restraint stress by restoring the oxidatant-antioxidant balance in the total fraction of gastric mucosa cells. Pro-Gly was least effective in ...

journal_title：Bulletin of experimental biology and medicine

authors： Falalyeyeva TM,Samonina GE,Beregovaya TV,Andreeva LA,Dvorshchenko EV

更新日期：2010-07-01 00:00:00

abstract：:Secretion and synthesis of vasopressin was studied in adult male Wistar rats receiving lipopolysaccharide in a dose of 250 microg/100 g body weight and subjected to moderate osmotic stimulation (2% NaCl perorally for 6 days). Lipopolysaccharide stimulated secretion of vasopressin into the blood. It should be emphasize...

journal_title：Bulletin of experimental biology and medicine

authors： Liskina EB,Grinevich VV,Volkova OV,Akmaev IG

更新日期：2003-08-01 00:00:00

abstract：:Cytochrome p450-mediated metabolism of GRS (indolinone antiaggregant) and its effects on activities of cytochrome p450 isoenzymes were studied. Inhibition of 6 isomers of cytochrome p450 in human liver microsomes was studied with the use of specific substrates. It was found that human liver cytochrome p450 enzymes cou...

journal_title：Bulletin of experimental biology and medicine

authors： Bykov VV,Leonov KA,Serebrov VY,Chernysheva GA,Smol'yakova VI,Solov'ev MA,Udut EV,Fisenko VP,Udut VV

更新日期：2020-04-01 00:00:00

abstract：:Time course of DNase and RNase activities in the sera of random-bred mice infected with Plasmodium malariae (chloroquine-sensitive strain H) was studied. Similarly to viral infection, infection with a protozoa eukaryotic parasite was accompanied by increased DNAse and RNAse activities, though Plasmodium malariae biolo...

journal_title：Bulletin of experimental biology and medicine

authors： Kovalenko GA,Gal'vita AV

更新日期：2000-09-01 00:00:00

abstract：:Animals were immunized with transmissible gastroenteritis virus conjugated with gold nanoparticles. The resultant antibodies had a higher titer than antibodies produced in response to native virus. Immunization with the antigen-colloidal gold complex led to a significant increase of the peritoneal macrophages respirat...

journal_title：Bulletin of experimental biology and medicine

authors： Staroverov SA,Vidyasheva IV,Gabalov KP,Vasilenko OA,Laskavyi VN,Dykman LA

更新日期：2011-08-01 00:00:00

abstract：:We studied the effects of chronic administration of granulocyte colony-stimulating factor in nonmobilizing doses to mice. Over 18 months of the study, 55% animals of the treatment group died of unknown cause, blood diseases and tumors were found in 20% mice, and in 5% animals pathological changes were absent. Control ...

journal_title：Bulletin of experimental biology and medicine

authors： Nifontova IN,Svinareva DA,Chertkov IL,Drize NI,Savchenko VG

更新日期：2008-05-01 00:00:00

abstract：:Changes in the muscular tissue after subcutaneous injection of autologous bone marrow multipotent mesenchymal stromal cells transfected with GFP gene and additionally stained with cell membrane dye Vybrant CM-Dil in the projection of ligated femoral vein were studied by light microscopy with luminescence. Stromal cell...

journal_title：Bulletin of experimental biology and medicine

authors： Maiborodin IV,Morozov VV,Anikeev AA,Maslov RV,Figurenko NF,Matveeva VA,Maiborodina VI

更新日期：2018-03-01 00:00:00

abstract：:Tetrapeptide H-Ala-Glu-Asp-Arg-OH enhances the expression of cytoskeletal (actin, tubulin, vimentin) and nuclear matrix proteins (lamin A, lamin C) in cultured mouse embryonic fibroblasts by 2-5 and 2-3 times, respectively. Thus, the previously reported cardioprotective activity of this tetrapeptide is determined by i...

journal_title：Bulletin of experimental biology and medicine

authors： Khavinson VKh,Lin'kova NS,Polyakova VO,Kvetnoy IM,Benberin VV,D'yakonov MM,Titkov YS

更新日期：2012-08-01 00:00:00

abstract：:Two-year experiments were performed to evaluate the neurotrophic effect of hypoxia-inducible factors (vascular endothelial growth factor and angiogenin) expressed in recombinant human adenoviruses in amyotrophic lateral sclerosis. Randomized placebo-controlled trial demonstrated safety and good tolerability of the rec...

journal_title：Bulletin of experimental biology and medicine

authors： Zavalishin IA,Bochkov NP,Suslina ZA,Zakharova MN,Tarantul VZ,Naroditskiy BS,Suponeva NA,Illarioshkin SN,Shmarov MM,Logunov DY,Tutyhina IL,Verkhovskaya LV,Sedova ES,Vasiliev AV,Brylev LV,Ginzburg AL

更新日期：2008-04-01 00:00:00

abstract：:We designed a new complex drug with antiallergic effect containing, in addition to the main component loratadine, a phytocomplex for an extra therapeutic effect. A collection of plants with sedative activity is chosen and the optimal agent for extraction of bioactive compounds (40% ethanol) and optimal degree of plant...

journal_title：Bulletin of experimental biology and medicine

authors： Kulikovskii VF,Zhilyakova ET,Novikov OO,Pisarev DI,Prokushchenko NV,Ivanova LL

更新日期：2017-10-01 00:00:00

abstract：:The cytotoxic effects of human blood serum were studied under normal and pathological conditions. The contribution of the complement system to the realization of this effect was demonstrated. Significant differences in the serum capacity to kill foreign cells were detected for healthy subjects and asthmatics. Bovine s...

journal_title：Bulletin of experimental biology and medicine

authors： Arkhipova EN,Cherepov AB,Medvedeva YS,Alchinova IB,Karganov MY

更新日期：2012-09-01 00:00:00

abstract：:Peculiarities of skin extension under vacuum applicators (nozzles) of various design was studied in 20 volunteers aged 18-25 years. The data obtained made it possible to chose optimal parameters of elastic membranes of the vacuum cups that produce stretch sufficient for vacuum-membrane skeletal muscle extension with m...

journal_title：Bulletin of experimental biology and medicine

authors： Alekseev YN,Smirnov BM,Alekseev NY

更新日期：2002-02-01 00:00:00

abstract：:Laser radiation of different power had various effects on the properties of erythrocytes. An increase in the radiation power from 2.2 to 25 mW/cm2 was accompanied by a decrease in the erythrocyte sedimentation rate and an increase in erythrocyte filtration index. Radiation of 50 mW/cm2 induced abnormal erythrocyte agg...

journal_title：Bulletin of experimental biology and medicine

authors： Lin'kova NS,Gorshkova OP,Shuvaeva VN,Dvoretskii DP

更新日期：2008-01-01 00:00:00

abstract：:The effects of cerivastatin on antiatherogenic properties of high-density lipoproteins were studied in patients with coronary heart disease and hyperlipidemia. Apart from hypolipidemic effects, cerivastatin changed the phospholipid composition of high-density lipoproteins and improved their cholesterol-acceptor proper...

journal_title：Bulletin of experimental biology and medicine

authors： Ozerova IN,Jeevan DM,Serdyuk AP,Paramonova IV,Akhmedzhanov NM,Metel'skaya VA,Perova NV

更新日期：2000-10-01 00:00:00