Abstract：
:Hemopoietic islets, associations of stromal (macrophages, fibroblasts) and blood (including stem) cells, are structural and functional units of the bone marrow. We studied cellular and molecular processes developing following short-term (1 h) contact of hemopoietic islets with ferromagnetic nanoparticles in a multicellular system of the bone marrow in vitro. It was established that nanodispersions of magnetite (Fe(3)O(4), mean particle diameter 18 nm) and iron coated with carbon (Fe(C), particle diameter 5-10 nm) in a dose of 3 mg/liter had a minor effect on processes of necrotic and apoptotic cell death. Nanodispersion of carbon-coated iron (Fe(C)) most mildly stimulated oxidizing processes recorded by intracellular levels of reactive oxygen species. These nanoparticles, in contrast to magnetite, did not reduce the amount of hemopoietic islets in the bone marrow cell suspension.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Novitsky VA,Khlusov IA,Ryazantseva NV,Chechina OE,Feduschak TA,Ermakov AE,Uimin MAdoi
10.1007/s10517-011-1360-6subject
Has Abstractpub_date
2011-08-01 00:00:00pages
473-6issue
4eissn
0007-4888issn
1573-8221journal_volume
151pub_type
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