Abstract：
:We studied the structure of rhythms of BP, HR (by telemetric monitoring), electrolyte excretion (by capillary electrophoresis), and products of epiphyseal melatonin (by the urinary concentration of 6-sulfatoxymelatonin measured by ELISA) in normotensive Wistar-Kyoto rats and spontaneously hypertensive SHR rats maintained at 16/8 h and 20/4 h light-dark regimes. In Wister-Kyoto rats exposed to prolonged daylight, we observed changes in the amplitude, rhythm power (% of rhythm), and range of oscillations of systolic BP; HR mezor decreased. In SHR rats, mezor of HR also decreased, but other parameters of rhythms remained unchanged. Changes in electrolyte excretion were opposite in normo- and hypertensive rats. Under conditions of 20/4 h light-dark regime, daytime melatonin production tended to increase in normotensive rats and significantly increased in SHR rats. At the same time, nighttime melatonin production did not change in both normotensive and hypertensive animals. As the secretion of melatonin has similar features in animals of both lines, we can say that the epiphyseal component of the "biological clock" is not the only component of the functional system that determines the response of the studied rhythms to an increase in the duration of light exposure.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Blagonravov ML,Bryk AA,Medvedeva EV,Goryachev VA,Chibisov SM,Kurlaeva AO,Agafonov EDdoi
10.1007/s10517-019-04636-4subject
Has Abstractpub_date
2019-11-01 00:00:00pages
18-23issue
1eissn
0007-4888issn
1573-8221pii
10.1007/s10517-019-04636-4journal_volume
168pub_type
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