Abstract:
:We propose a new surgical approach to the treatment of familial colorectal adenomatous polyposis implying preservation of a portion of the rectum with removed mucosa. For reconstruction of the rectum, allotransplantation of the mixed culture of fetal allogenic somatic cells of the intestinal epithelium and mesenchymal cells of various origin is used. The mechanisms of mucosa reparation were studied in 34 patients. Endoscopic, morphological, and immunohistochemical studies showed that cell transplantation considerably accelerated reparation of the mucosa in mucosectomized rectum. The proposed treatment of familial colorectal adenomatous polyposis allows delaying the development of rectal polyps and cancer for many years.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Kogan EA,Vyshegorodtsev DV,Faizullina NM,Demura TA,Kuz'minov AM,Shelygin YA,Sukhikh GTdoi
10.1007/s10517-014-2643-5subject
Has Abstractpub_date
2014-09-01 00:00:00pages
683-8issue
5eissn
0007-4888issn
1573-8221journal_volume
157pub_type
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