Abstract:
:Total antioxidant activity of the serum in patients with liver pathology was assessed by two chemiluminescent methods based on different models of free radical oxidation: Hb-H2O2-luminol and ABAP-luminol. Comparative analysis showed a significant, but not high correlation of the results (r=0.798), which can be explained by different mechanisms of induction of free radicals and effects of various serum components (proteins and bilirubin) on the initiation process. The influence of aphysiological concentration of analyzed values manifested in the Hb-H2O2 model. Disagreement between the results of measurements was more pronounced in patients with abnormally high serum bilirubin content. The results suggested that ABAP-luminol chemiluminescent model is more preferable for evaluation of antioxidant activity in clinical practice.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Titov VN,Sazhina NNdoi
10.1007/s10517-014-2742-3subject
Has Abstractpub_date
2014-12-01 00:00:00pages
287-9issue
2eissn
0007-4888issn
1573-8221journal_volume
158pub_type
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