Evaluation of serum antioxidant activity in patients with liver pathology by the chemiluminescent method.

Abstract:

:Total antioxidant activity of the serum in patients with liver pathology was assessed by two chemiluminescent methods based on different models of free radical oxidation: Hb-H2O2-luminol and ABAP-luminol. Comparative analysis showed a significant, but not high correlation of the results (r=0.798), which can be explained by different mechanisms of induction of free radicals and effects of various serum components (proteins and bilirubin) on the initiation process. The influence of aphysiological concentration of analyzed values manifested in the Hb-H2O2 model. Disagreement between the results of measurements was more pronounced in patients with abnormally high serum bilirubin content. The results suggested that ABAP-luminol chemiluminescent model is more preferable for evaluation of antioxidant activity in clinical practice.

journal_name

Bull Exp Biol Med

authors

Titov VN,Sazhina NN

doi

10.1007/s10517-014-2742-3

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

287-9

issue

2

eissn

0007-4888

issn

1573-8221

journal_volume

158

pub_type

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