Hemostimualting properties of preparation containing ultralow doses of antibodies to stem cell factor in cytostatic myelosuppression.

Abstract:

:Preparation containing ultralow doses of antibodies to stem cell factor considerably activates bone marrow myelopoiesis suppressed by cyclophosphamide. This effect of the preparation is based on stimulation of proliferation of committed hemopoietic precursors and increase in functional activity of adherent elements of hemopoiesis-inducing microenvironment.

journal_name

Bull Exp Biol Med

authors

Stavrova LA,Zyuz'kov GN,Simanina EV,Miroshnichenko LA,Udut EV,Khrichkova TY,Skurikhin EG,Pershina OV,Ermakova NN,Firsova TV,Zhdanov VV,Dygai AM,Gol'dberg ED

doi

10.1007/s10517-010-0764-z

subject

Has Abstract

pub_date

2009-09-01 00:00:00

pages

556-9

issue

3

eissn

0007-4888

issn

1573-8221

journal_volume

148

pub_type

杂志文章
  • Changes in caval blood flow and right atrial pressure in response to catecholamines.

    abstract::The type and magnitude of changes in blood flow in the anterior (cranial) and posterior (caudal) caval veins and shifts in the mean right atrial pressure induced by catecholamines (epinephrine and norepinephrine) were studied in acute experiments on cats. It was found that irrespective of right atrial pressure shifts,...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1022617709181

    authors: Tkachenko BI,Evlakhov VI,Poyasov IZ

    更新日期:2002-11-01 00:00:00

  • A new method for express analysis of flavonoid fraction in nephrophite plant extract and prediction of its antioxidant effects.

    abstract::A new chromatographic procedure is proposed for rapid (35 min) complete fractionation of flavonoids in plant raw material; the method well discriminates between components with antioxidant activity (rutin, apigenin, quercetin, hesperidin). The method is based on reverse-phase high performance liquid chromatography usi...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-006-0273-2

    authors: Markaryan AA

    更新日期:2006-06-01 00:00:00

  • Polymorphism of Matrix Metalloproteinases Genes MMP1, MMP2, MMP3, and MMP7 and the Risk of Varicose Veins of Lower Extremities.

    abstract::We studied the effects of single nucleotide polymorphisms in the promoter regions of matrix metalloproteinase genes rs1799750 (-1607dupG) MMP1, rs243865 (C-1306T) MMP2, rs3025058 (-1171dupA) MMP3, and rs11568818 (A-181G) MMP7 on the risk of varicose vein of the lower extremities in ethnical Russians, residents of the ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-017-3871-2

    authors: Shadrina AS,Smetanina MA,Sevost'yanova KS,Shevela AI,Seliverstov EI,Zakharova EA,Voronina EN,Ilyukhin EA,Zolotukhin IA,Kirienko AI,Filipenko ML

    更新日期:2017-09-01 00:00:00

  • Use of saliva crystallogenic properties for early diagnostics of prostate cancer.

    abstract::Multivariate analysis was used to examine the morphology of mixed saliva crystals in 55 healthy men and the patients with suspected malignant prostate gland diseases. The established changes in the shape of dendritic crystals in the saliva from prostate-problematic patients were corroborated by the cluster and discrim...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-006-0338-2

    authors: Denisov AB,Pushkar' DY,Denisov SA

    更新日期:2006-08-01 00:00:00

  • Modulation of α-rhythm and autonomic status of human by color photostimulation.

    abstract::The effects of photostimulation with different colors on α-rhythm amplitude and parameters of variation pulsometry were studied. Green color stimulation modulates human functions: ?-rhythm amplitude increases by 1.06 μV/√Hz (p<0.05) and the index of regulatory systems strain decreases significantly (p<0.05). ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-010-1046-5

    authors: Osipova MA,Arkov VV,Tonevitsky AG

    更新日期:2010-11-01 00:00:00

  • Changes in phenotype of monocyte-like THP-1 cells associated with transendothelial migration.

    abstract::The level of expression of CD11b and HLA-DR surface molecules on monocyte-like THP-1 cells increased significantly as a result of transmigration of these cells through a monolayer of endothelial cells. The expression of all studied markers (CD11b, HLA-DR, and CD-14) increased significantly after transendothelial migra...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-009-0350-4

    authors: Starikova EA,Sokolov DI,Chernova AA,Freidlin IS

    更新日期:2008-11-01 00:00:00

  • L-Lysine-α-Oxidase: Acidovorax citrulli Bacterium Inhibitor.

    abstract::Studies of the effects of Trichoderma harzianum Rifai F-180 culture fluid concentrate containing L-lysine-α-oxidase antitumor enzyme produced by the fungus and the homogenous enzyme, on ultrahazardous bacterium Acidovorax citrulli demonstrated the antibacterial activity of the concentrate. Trichoderma harzianum Rifai ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-018-4012-2

    authors: Smirnova IP,Karimova EV,Shneider YA,Volina EG

    更新日期:2018-03-01 00:00:00

  • Evaluation of the efficiency and safety of anaferon (pediatric formulation) in the treatment of chickenpox in children.

    abstract::Addition of anaferon (pediatric formulation) to the therapy of chickenpox patients led to more rapid disappearance of the main symptoms and alleviated the course of the disease. The safety of the preparation is confirmed by the absence of undesirable events and stability of laboratory indexes against the background of...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s10517-009-0698-5

    authors: Timchenko VN,Pavlova EB,Chernova TM,Bannova SL,Savel'eva TI,Tarasov SA,Kachanova MV,Siver'yanova MA

    更新日期:2009-08-01 00:00:00

  • Negative regulation of caspase-3 expression in the neonatal cerebral cortex by alpha2A-adrenoceptors.

    abstract::Antisense oligonucleotide to alpha2A-adrenoceptors increased the levels of mRNA (reverse polymerase chain reaction) and protein for a key executioner protease of apoptosis caspase-3 (immunoblotting assay) in the cerebral cortex of newborn rats. The relationship between the observed effect and low expression of alpha2-...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-007-0088-9

    authors: Men'shanov PN,Bannova AV,Il'inykh FA,Dygalo NN

    更新日期:2007-03-01 00:00:00

  • Role of MEK, PI3, p38, Tyrosine, and mTOR Kinases in Regulation of Heart Resistance to the Arrhythmogenic Action of Short-Term Ischemia and Reperfusion.

    abstract::MEK, PI3, p38, tyrosine, and mTOR kinases are not involved in the regulation of heart resistance to the arrhythmogenic action of short-term ischemia/reperfusion in non-adapted rats. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-015-2848-2

    authors: Maslov LN,Mukhomedzyanov AV,Tsibulnikov SY,Chauski EI,Khaliulin IG,Portnichenko AG

    更新日期:2015-04-01 00:00:00

  • Study of high-resolution H1 nuclear magnetic resonance spectra of the serum and its albumin faction in patients with the first schizophrenia episode.

    abstract::We studied high-resolution (1)H nuclear magnetic resonance spectra of the serum and serum albumin from patients with the first episode of schizophrenia and healthy individuals. A relative increase in signal intensities of CH(2) protons in serum LDL and VLDL in schizophrenia was demonstrated. Higher intensities of CH(2...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-012-1622-y

    authors: Babushkina TA,Klimova TP,Peregudov AS,Gryzunov YA,Smolina NV,Dobretsov GE,Uzbekov MG

    更新日期:2012-04-01 00:00:00

  • Focal Unilateral Traumatic brain injury Causes Delayed Neurodegenerative Changes in the Brain of Rats.

    abstract::A cascade of pathological changes in the intact hemisphere developed in rats 6 months after focal unilateral traumatic brain injury: neuronal degeneration, hyperexpression of α-synuclein, APP (β-amyloid peptide precursor) protein, and glutamine synthetase in cells other than astrocytes. The development of these change...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-017-3960-2

    authors: Genrikhs EE,Voronkov DN,Kapkaeva MR,Isaev NK,Stelmashook EV

    更新日期:2017-12-01 00:00:00

  • Effect of electromagnetic radiation modulated by biostructures on the course of alloxan-induced diabetes mellitus in rats.

    abstract::Exposure of rats with experimental diabetes mellitus to wide-band electromagnetic radiation generated by He-Ne laser and modulated by the pancreas and spleen is informing and phenomenological method prolonging animal life span, normalizing blood glucose level, and promoting regeneration of the pancreas. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-007-0049-3

    authors: Garyaev PP,Kokaya AA,Mukhina IV,Leonova-Garyaeva EA,Kokaya NG

    更新日期:2007-02-01 00:00:00

  • The role of the serotoninergic system in the regulation of thyroid function in old rats.

    abstract::The effect of serotoninotropic substances with positive and negative effects on serum concentrations of thyrotropic hormone, total triiodothyronine, and total thyroxin was studied in old male rats. Chronic treatment with L-tryptophan and citalopram reduced serum level of total thyroxin in old intact animals and serum ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-010-0824-4

    authors: Masalova OO,Sapronov NS

    更新日期:2009-11-01 00:00:00

  • Models of reactions of human heart as nonlinear dynamic system to cosmic and geophysical factors.

    abstract::The paper analyzes theoretical models of the adaptive modes of generation and stability of human heart as a nonlinear point source. The analysis encompasses only ECG time-domain dynamics. To solve the general problem of the study of the adaptive changes of the cardiosignal under the action of external periodic force a...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-010-0977-1

    authors: Pipin VV,Ragulskaya MV,Chibisov SM

    更新日期:2010-10-01 00:00:00

  • Processes of DNA methylation are involved in the mechanisms of amnesia induction and conditioned food aversion memory reconsolidation.

    abstract::We studied the role of DNA methylation in the mechanisms of amnesia in edible snails, which was induced by impairment of conditioned food aversion memory reconsolidation with NMDA glutamate receptor antagonist. The effects of DNA methyltransferase inhibitors were shown to depend on the stage of amnesia. At the early s...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-014-2367-6

    authors: Solntseva SV,Filatova TS,Nikitin PV,Bredov DV,Kozyrev SA,Nikitin VP

    更新日期:2014-02-01 00:00:00

  • NAD and glutathione modulate sensitivity of bone marrow cells to oxidative stress.

    abstract::We studied in vitro cytostatic effect of doxorubicin on bone marrow cells preincubated with NAD and reduced glutathione. The presence of NAD and glutathione in the medium potentiated membrane toxicity of this antibiotic, but prevented its toxic effects on intracellular pool of pyridine nucleotides during oxidative str...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1012511808353

    authors: Egorova AB,Uspenskaya YA,Nefedov VP

    更新日期:2001-07-01 00:00:00

  • Seasonal effects of Selank on the behavior of hibernating animals.

    abstract::We studied the seasonal effects of peptide preparation Selank on orientation and exploratory activity in 36 arctic ground squirrels Citellus undulatus in the open-field and hole-board tests. Selank most significantly increased behavioral activity of hibernating animals in the spring and fall. The test peptide had no e...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-006-0060-0

    authors: Semenova TP,Kozlovskaya MM,Zuikov AV,Kozlovskii II,Andreeva LA

    更新日期:2005-12-01 00:00:00

  • Structural and functional state of the bone marrow during its in vitro interaction with ferromagnetic nanoparticles.

    abstract::Hemopoietic islets, associations of stromal (macrophages, fibroblasts) and blood (including stem) cells, are structural and functional units of the bone marrow. We studied cellular and molecular processes developing following short-term (1 h) contact of hemopoietic islets with ferromagnetic nanoparticles in a multicel...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-011-1360-6

    authors: Novitsky VA,Khlusov IA,Ryazantseva NV,Chechina OE,Feduschak TA,Ermakov AE,Uimin MA

    更新日期:2011-08-01 00:00:00

  • Phospholipid hydrolysis with phospholipases A2 and C impairs apolipoprotein B-100 conformation on the surface of low density lipoproteins by reducing their association resistance.

    abstract::Modification of apolipoprotein B-100 conformation on the surface of LDL isolated from human blood was demonstrated by enzyme immunoassay with a panel of monoclonal antibodies to this protein. The study by the light transmission fluctuation method showed that incubation of LDL with phospholipases A2 or C led to associa...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-005-0508-7

    authors: Aksenov DV,Mel'nichenko AA,Suprun IV,Yanushevskaya EV,Vlasik TN,Sobenin IA,Panasenko OM,Orekhov AN

    更新日期:2005-10-01 00:00:00

  • Role of ryanodine receptors in the effects of hydrogen sulfide on transmitter release from the frog motor nerve ending.

    abstract::We studied the role of ryanodine receptors in the effects of hydrogen sulfide on transmitter release from frog motor nerve ending. Sodium hydrosulfide (300 μM), a donor of hydrogen sulfide, reversibly increased the frequency of miniature endplate current without changes in its amplitude-time parameters. These effects ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-013-2067-7

    authors: Gerasimova EV,Yakovleva OV,Zefirov AL,Sitdikova GF

    更新日期:2013-05-01 00:00:00

  • Analysis of the Expression of Regulator Genes in Kupffer Cells and Monocytes.

    abstract::Differences in the gene expression profiles in resident macrophages (in particular, Kupffer cells) and monocytes were revealed. However, these differences in gene expression profiles do not allow considering resident liver macrophages as purely M2 macrophages and monocytes as purely M1 macrophages. At the same time, a...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-020-04752-6

    authors: Nikitina MP,Elchaninov AV,Lokhonina AV,Makarov AV,Tagirova MK,Grinberg MV,Bolshakova GB,Glinkina VV,Goldshtein DV,Fatkhudinov TK

    更新日期:2020-02-01 00:00:00

  • Inhibition of cytochrome P-450 with 2-diethylamino-ethyl-2,2-diphenylpropylacetate (SKF-525A) reduces immunotoxicity of chlorinated carbohydrates.

    abstract::Experiments on outbred albino rats showed that single intraperitoneal injection of cytochrome P-450 inhibitor 2-diethylaminoethyl-2,2-diphenylpropylacetate (SKF-525A) in a dose of 50 mg/kg before acute poisoning with 1,2-dichloroethane and trichloroethane in a dose of 1.0 LD(50), metabolized in the body to compounds w...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-006-0357-z

    authors: Zabrodskii PF,Mandych VG,Germanchuk VG

    更新日期:2006-09-01 00:00:00

  • Neurological Deficit and Structural Changes in Lymphoid Structures of the Tracheal Wall in the Immediate Stage of Experimental Hemorrhagic Stroke in Rats with Different Behavioral Activity.

    abstract::Specific features of neurological deficit and changes in the cellular composition of tracheal lymphoid structures during the immediate stage (day 1) of hemorrhagic stroke were studied in rats with various behavioral parameters. Modeling of hemorrhage in the left caudate nucleus of the brain was followed by the develop...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-019-04424-0

    authors: Klyueva LV,Koplik EV,Vasyanina KA,Pertsov SS

    更新日期:2019-04-01 00:00:00

  • Effect of laser radiation on production of reactive oxygen species in the blood of patients with chronic obstructive pulmonary disease.

    abstract::The effect of laser radiation on generation of reactive oxygen species in the whole blood from patients with chronic obstructive pulmonary disease was studied by in vitro recording of luminol-dependent chemiluminescence. Laser irradiation of the blood from patients with increased production of reactive oxygen species ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-007-0299-0

    authors: Farkhutdinov UR,Farkhutdinov ShU

    更新日期:2007-08-01 00:00:00

  • Relationship between free-radical lipid oxidation and efficiency of coronary angioplasty in coronary patients.

    abstract::Low-dose (250 mg daily) oral probucol produces a significant antioxidant effect in coronary patients: increases activity of glutathione peroxidase (enzyme utilizing lipoperoxides) and reduces the content of free-radical oxidation products in the blood. Probucol therapy for 7 days before and for 6 months after coronary...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s10517-007-0399-x

    authors: Kaminnyi AI,Lankin VZ,Perepelitsa EI,Konovalova GG,Samko AN,Tikhaze AK,Kukharchuk VV,Belenkov YN

    更新日期:2007-11-01 00:00:00

  • Experimental study of hepatoprotective activity of hydroxymethyluracil.

    abstract::Hepatoprotective activity of pyrimidine derivative hydroxymethyluracil was studied on the model of acute paracetamol-induced liver damage in rats. Hydroxymethyluracil was shown to produce a strong hepatoprotective effect. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-007-0183-y

    authors: Mirsaev TR

    更新日期:2007-05-01 00:00:00

  • Effects of Oxytocin on the Levels and Metabolism of Monoamines in the Brain of White Outbred Mice during Long-Term Social Isolation.

    abstract::The effects of intranasal administration of oxytocin on the levels and metabolism of monoamines in symmetrical structures of the brain of white outbred mice kept under conditions of long-term social isolation were studied by HPLC. Disappearance of initial right-sided asymmetry in the content of dopamine metabolites in...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-017-3887-7

    authors: Karpova IV,Bychkov ER,Marysheva VV,Mikheev VV,Shabanov PD

    更新日期:2017-10-01 00:00:00

  • Effect of calcium-regulating hormones and calcium channel modulators on glucose consumption by muscle and adipose tissues in vivo and in vitro.

    abstract::We studied the effects of calcitonin, parathyrin, and Ca(2+) channel antagonist isoptin and agonist Bay-K-8644 on glucose consumption by muscle (diaphragm) and adipose (epididymal) tissues and insulin-stimulated glucose consumption in vivo and in vitro. Calcitonin and parathyrin did not alter glucose consumption; para...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-009-0677-x

    authors: Butakova SS,Nozdrachev AD

    更新日期:2009-08-01 00:00:00

  • Anticoagulant Effects of Arginine-Containing Peptides of the Glyproline Family (His-Phe-Arg-Trp-Pro-Gly-Pro and Thr-Lys-Pro-Arg-Pro-Gly-Pro) Revealed by Thromboelastography.

    abstract::Thromboelastography revealed anticoagulant effects of 3 glyproline oligopeptides (in various concentrations): His-Phe-Arg-Trp-Pro-Gly-Pro, Thr-Lys-Pro-Arg-Pro-Gly-Pro (Selank), and Pro-Gly-Pro. The parameters R, K, MA, S, TMA, and J changed to hypocoagulation direction in comparison to the control. At this, Selank dem...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-017-3950-4

    authors: Rogozinskaya EY,Lyapina MG

    更新日期:2017-12-01 00:00:00