Xenotransplantation of embryonic precursors of human myogenesis for the correction of dystrophinopathy in mice with hereditary muscular dystrophy.

Abstract:

:Human embryonic myogenic precursors were transplanted into muscles of mdx mice with hereditary dystrophin-deficient muscular dystrophy. Transplantation induced the synthesis of human dystrophin. The number of dystrophin-positive fibers progressively decreased, however, some of them were preserved even 5 months after transplantation. Our results indicate that xenogeneic transplantation of embryonic myogenic precursors compensates the genetic defect in dystrophin-deficient mice.

journal_name

Bull Exp Biol Med

authors

Yarygin VN,Sukhikh GT,Sitnikov VF,Stenina MA,Kuznetsov AB,Poltavtseva RA,Krivov LI,Voevodin DA,Savchuk VI,Revishchin AV,Korochkin LI,Aleksandrova MA

doi

10.1023/a:1026009517850

subject

Has Abstract

pub_date

2003-07-01 00:00:00

pages

88-92

issue

1

eissn

0007-4888

issn

1573-8221

journal_volume

136

pub_type

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