Abstract:
:Medical histories of 101 urothelial bladder cancer patients were compared with the results of morphological analysis and biomolecular detection of human papilloma viruses (HPV) in the tumor specimens. DNA of HPV16 (the major type of virus responsible for appearance of cervical carcinoma) was detected in 38 specimens, while mRNA of E6 and E7 oncogenes and E7 oncoprotein of HPV16 were observed in 13 specimens. HPV-positive bladder cancer was characterized by higher degree of cell anaplasia than HPV-negative cancer; in the primary bladder tumor, HPV was detected more often than in recurrent bladder cancer. These data attest to involvement of HPV16 in the genesis of bladder cancer. No correlations of HPV status of bladder tumor with patient's sex, age, and invasion into the muscle layer were revealed.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Golovina DA,Ermilova VD,Zavalishina LE,Andreeva YY,Matveev VB,Frank GA,Volgareva GMdoi
10.1007/s10517-016-3354-xsubject
Has Abstractpub_date
2016-05-01 00:00:00pages
96-8issue
1eissn
0007-4888issn
1573-8221pii
10.1007/s10517-016-3354-xjournal_volume
161pub_type
杂志文章abstract::We studied the mechanisms of induction of recombinase activity in peripheral T cells of patients with autoimmune type 1 diabetes mellitus. It was shown that the presence of CD40 on T cell membrane (not typical of these cells) is crucial for this process: expression of recombinase RAG-1 in diabetic patients was detecte...
journal_title:Bulletin of experimental biology and medicine
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