Abstract:
:NAD, cytochrome c, and energostim modulated the fluorescence emission spectrum of trifluoperazine in the solution and in microsomal suspension. The data suggest that NAD and energostim modify structural and conformational characteristics of the dopamine receptor-trifluoperazine complex. These changes probably underlie the anticataleptic effect of energostim.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Chikobava EA,Galenko-Yaroshevskii PA,Gurskaya EV,Mamuchishvili IG,Sukoyan GVdoi
10.1023/b:bebm.0000031560.92650.3dsubject
Has Abstractpub_date
2004-03-01 00:00:00pages
246-8issue
3eissn
0007-4888issn
1573-8221pii
doijournal_volume
137pub_type
杂志文章abstract::Hypoxia-induced immediate expression of transcription factor HIF-1α in the brain cortex is regulated by succinate produced in both the tricarbonic acid cycle and GABA shunt reactions and is induced by succinate-containing drugs. These facts prove the existence of succinate-dependent signalling regulation involved in i...
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journal_title:Bulletin of experimental biology and medicine
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