Abstract:
:Hypoxia-induced immediate expression of transcription factor HIF-1α in the brain cortex is regulated by succinate produced in both the tricarbonic acid cycle and GABA shunt reactions and is induced by succinate-containing drugs. These facts prove the existence of succinate-dependent signalling regulation involved in immediate and delayed molecular adaptation and increased body resistance to oxygen deficiency, where succinate acts as a signal molecule. The intensity of this process differs in animals with low and high resistance to hypoxia.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Lukyanova LD,Kirova YI,Germanova ELdoi
10.1007/s10517-018-3976-2subject
Has Abstractpub_date
2018-01-01 00:00:00pages
298-303issue
3eissn
0007-4888issn
1573-8221pii
10.1007/s10517-018-3976-2journal_volume
164pub_type
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