Abstract：
:We studied the mechanisms of induction of recombinase activity in peripheral T cells of patients with autoimmune type 1 diabetes mellitus. It was shown that the presence of CD40 on T cell membrane (not typical of these cells) is crucial for this process: expression of recombinase RAG-1 in diabetic patients was detected primarily in αβTCR(+)CD40(+) lymphocytes; targeted CD40-dependent activation of intact T cells in vitro increases, while blockade of CD40 signal in the culture of stimulated T cells abolishes recombinase expression.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Kuklina EM,Gorbunova OL,Smirnova ENdoi
10.1007/s10517-012-1522-1subject
Has Abstractpub_date
2012-01-01 00:00:00pages
336-9issue
3eissn
0007-4888issn
1573-8221journal_volume
152pub_type
杂志文章abstract：:We demonstrated specific changes in platelet structure in different types of tuberculous process, in particular, shift in the proportion between alpha-granules, dense granules, different disorders in the mitochondrial and lysosomal apparatus, etc. The role of platelets in immune process is studied. Redistribution of a...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-005-0084-x
更新日期：2004-11-01 00:00:00
abstract：:Isolated rat hearts were subjected to 30-min coronary artery occlusion followed by 120-min reperfusion. The hearts (n=8-12) were perfused with Krebs-Henseleit solution enriched with L-carnitine (0.5, 2.5 and 5 mM) for 10 min before and after ischemia or reperfusion and for the whole period of ischemia and reperfusion....
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-008-0249-5
更新日期：2008-08-01 00:00:00
abstract：:Angiogenic action of compound GK-2, a dimeric dipeptide mimetic of loop 4 of nerve growth factor (NGF), was studied in in vitro and in vivo experiments. Experiments on human endothelial cell culture HUVEC showed that compound GK-2 significantly (p<0.05) stimulated the initial stage of angiogenesis, and its angiogenic ...
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doi：10.1007/s10517-016-3450-y
更新日期：2016-08-01 00:00:00
abstract：:The efficiency of drug therapy should be evaluated by not only its directed action on specific organ or target parameter, but also its effects on general regulatory and adaptive status. ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 临床试验,杂志文章
doi：10.1007/s10517-008-0195-2
更新日期：2008-06-01 00:00:00
abstract：:Neurospecific proteins S-100 and GFAP were measured in the serum of 145 patients with neural tumors and 69 healthy individuals. In patients with glyoblastomas, the concentrations of S-100 and GFAP were significantly higher than in patients with anaplastic astrocytomas, benign meningiomas, and brain metastases and in h...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-011-1236-9
更新日期：2011-04-01 00:00:00
abstract：:The antidepressant, psychostimulant, and nootropic effects of a composition of major and trace elements including KCl, RbNO3, magnesium sulfate, and zinc sulfate were studied on the models of behavioural despair (Porsolt test) and conditioned passive avoidance test. The preparation was found to shorten the immobilizat...
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doi：10.1007/s10517-013-2113-5
更新日期：2013-06-01 00:00:00
abstract：:Dihydroquercetin (flavonoid of plant origin) immobilized with an amino acid in lecithin nanoparticles promotes reduction of inflammatory reactions in the wound after thermal burn. The use of a liposomal complex in burn injury stabilizes endogenous antioxidant system and limits the secondary necrotic zone in the wounds...
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doi：10.1007/s10517-010-0876-5
更新日期：2010-07-01 00:00:00
abstract：:We studied the effect of 20 standard L-amino acids on proliferation of the nervous, cardiovascular, urogenital, digestive, and immune system tissues from young and old animals in organotypic cultures. The effect of amino acids on tissue culture proliferation depended on their origin and animal age. ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-013-2200-7
更新日期：2013-08-01 00:00:00
abstract：:The effects of photostimulation with different colors on α-rhythm amplitude and parameters of variation pulsometry were studied. Green color stimulation modulates human functions: ?-rhythm amplitude increases by 1.06 μV/√Hz (p<0.05) and the index of regulatory systems strain decreases significantly (p<0.05). ...
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doi：10.1007/s10517-010-1046-5
更新日期：2010-11-01 00:00:00
abstract：:We measured activity of angiotensin-converting enzyme in plasma and tissue of NISAG and normotensive WAG rats. In different organs of NISAG rats, activity of this enzyme did not differ from the corresponding values of WAG rats, although enzyme activity in the plasma of NISAG rats was significantly lower than that of W...
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doi：10.1007/s10517-005-0498-5
更新日期：2005-10-01 00:00:00
abstract：:Drug resistance and viability of Mycobacterium tuberculosis were studied in 637 patients with pulmonary tuberculosis, detected by screening fluorography (group 1) and in 909 patients in whom the specific process was detected when they applied for medical care (group 2). The mycobacteria in the two groups did not diffe...
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doi：10.1007/s10517-014-2694-7
更新日期：2014-11-01 00:00:00
abstract：:In vivo cytogenetic effects of cyclophosphamide was simultaneously evaluated in 7 mouse organs. Cyclophosphamide produced most pronounced changes in the urinary bladder and bone marrow, the main target organs for this carcinogen. Mutagenic effects of the preparation were also detected in the lungs, large intestine, an...
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doi：10.1023/a:1017916622451
更新日期：2001-04-01 00:00:00
abstract：:We performed immunohistochemical analysis of the expression of TGFβ, galectin-1, vimentin, and thrombospondin in the mucosa in gastric cancer of diffuse and intestinal type associated with systemic undifferentiated connective tissue dysplasia. In diffuse gastric cancer, both with and without association with connectiv...
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doi：10.1007/s10517-019-04438-8
更新日期：2019-04-01 00:00:00
abstract：:Number and size of aggregated lymphoid nodules in the small intestine of mice exposed to radiation using a γ-irradiation unit GOBO-60 with 137Cs source were measured using the methods of visual microscopy and morphometry. Morphological status of the nodules was estimated on days 4, 28, 60, and 90 after the exposure. S...
journal_title：Bulletin of experimental biology and medicine
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doi：10.1007/s10517-017-3961-1
更新日期：2017-12-01 00:00:00
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doi：10.1007/s10517-015-3118-z
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abstract：:Applications of cold and warm activated cellular immunity and orientation and exploratory behavior in mice. Application of cold increased the number of turns to the left in the open field, muscle force, and activity of the food instinct, and caused an increase in the total count of peripheral blood leukocytes. Warm ap...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-013-2052-1
更新日期：2013-04-01 00:00:00
abstract：:The dynamics of blood concentrations of reactive oxygen species and LPO products in patients with thermal injuries of different severity was studied. Monitoring of these parameters by chemiluminescent and spectrophotometric techniques helps to predict the course of burn shock and prevent complications. Erysod (0.004% ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/a:1022638213724
更新日期：2002-11-01 00:00:00
abstract：:We analyzed the concentration of extracellular DNA and its fractions in the dynamics of uncomplicated pregnancy Thirty women with singleton pregnancy were examined. The concentration of total, maternal, and fetal cell-free DNA in maternal blood was measured at gestation weeks 11-14, 24-26, and 30-32. The level of tota...
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doi：10.1007/s10517-018-4295-3
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abstract：:Increased proteasome activity was revealed in blood serum of patients with stage T1N0M0 head and neck squamous cell carcinoma in comparison with patients with chronic diseases of the larynx and laryngopharynx. This opens prospects of using chymotrypsin-like activity measurement for differential diagnosis of squamous c...
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doi：10.1007/BF02766081
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pub_type： 杂志文章
doi：10.1007/s10517-018-4228-1
更新日期：2018-09-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/a:1022944608428
更新日期：2002-12-01 00:00:00
abstract：:We studied the specific features of ultrasonic vocalization of Wistar rats in various motivational and emotional states. No significant changes were found in ultrasonic vocalization of rats during experimental food motivation and after the satisfaction of food requirements. The state of thirst and satisfaction of wate...
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doi：10.1007/s10517-012-1831-4
更新日期：2012-10-01 00:00:00
abstract：:Efficiency and mechanisms of action of photodynamic therapy of M-1 sarcoma were studied experimentally on rats using photodithazine, a novel chlorine photosensitizer. The tissue and cellular targets for this agent are vascular wall, plasma membrane of tumor cells, and intracellular structures responsible for prolifera...
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doi：10.1007/s10517-005-0133-5
更新日期：2004-12-01 00:00:00
abstract：:We studied the effects of dopamine D1/D2 receptor antagonists on the dynamics of acquisition and extinction of active avoidance responses and open field behavior in ovariectomized female rats. Dopamine D1 receptor antagonist SCH-23390 (0.1 mg/kg intraperitoneally) and dopamine D2 receptor antagonist sulpiride (10.0 mg...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-014-2407-2
更新日期：2014-03-01 00:00:00
abstract：:Experiments on male and female CC57BR/Mv mice differing by the sensitivity to carcinogenic effect of urethane on the lungs showed that castration 1 week before carcinogen challenge reduced the number of lung adenomas caused by it in males and somewhat increased the number of tumors in females. Exogenous testosterone a...
journal_title：Bulletin of experimental biology and medicine
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doi：10.1007/s10517-015-3075-6
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/BF02766101
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abstract：:The age-related features of ultrastructural reorganization of cardiomyocytes were studied in rats with anthracycline-induced injury. The development of regenerative and plastic insufficiency of cardiomyocytes in animals of various age groups was accompanied by stereotypic ultrastructural reorganization. The major chan...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-011-1266-3
更新日期：2011-05-01 00:00:00
abstract：:Experiments on hepatocyte culture showed that apolipoprotein A-I-tetrahydrocortisol complex increases the rate of DNA, RNA, and protein biosynthesis measured by radioactive label incorporation. Apolipoprotein E acted as competitor of the apolipoprotein A-I-tetrahydrocortisol complex and abolished biological activity o...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-007-0430-2
更新日期：2007-12-01 00:00:00
