Effect of Selank on Spontaneous Synaptic Activity of Rat Hippocampal CA1 Neurons.

Abstract:

:Application of anxiolytic drug Selank to hippocampal slices increased the amplitude and discharge rate of spontaneous inhibitory postsynaptic currents in rat hippocampal pyramidal CA1 neurons. In some neurons, Selank-induced up-regulation of spontaneous inhibitory postsynaptic currents was preceded by a transient decrease in this activity. In the examined concentration range (1-8 μM), Selank demonstrated no significant dose-dependence.

journal_name

Bull Exp Biol Med

authors

Povarov IS,Kondratenko RV,Derevyagin VI,Myasoedov NF,Skrebitsky VG

doi

10.1007/s10517-017-3676-3

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

640-642

issue

5

eissn

0007-4888

issn

1573-8221

pii

10.1007/s10517-017-3676-3

journal_volume

162

pub_type

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