Abstract:
:Application of anxiolytic drug Selank to hippocampal slices increased the amplitude and discharge rate of spontaneous inhibitory postsynaptic currents in rat hippocampal pyramidal CA1 neurons. In some neurons, Selank-induced up-regulation of spontaneous inhibitory postsynaptic currents was preceded by a transient decrease in this activity. In the examined concentration range (1-8 μM), Selank demonstrated no significant dose-dependence.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Povarov IS,Kondratenko RV,Derevyagin VI,Myasoedov NF,Skrebitsky VGdoi
10.1007/s10517-017-3676-3subject
Has Abstractpub_date
2017-03-01 00:00:00pages
640-642issue
5eissn
0007-4888issn
1573-8221pii
10.1007/s10517-017-3676-3journal_volume
162pub_type
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