Abstract：
:Activity and levels of protein and mRNA of 3-hydroxy-3-methyl-glutaryl-CoA reductase were estimated in rat liver after the administration of atorvastatin and simvastatin and their complexes with glycyrrhizic acid (atorvaglyzin and simvaglyzin). The amount of 3-hydroxy-3-methyl-glutaryl-CoA reductase protein in rats decreased by 13 and 25% (p<0.05) 24 h after treatment with atorvaglyzin and simvaglyzin, respectively. Activity of this enzyme decreased by 46% in rats treated with atorvaglyzin. The amount of messenger RNA in these groups significantly increased as compared to control group (untreated animals).
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Stakhneva EM,Vavilin VA,Ragino YI,Safronova OG,Shintyapina AB,Ivanova MVdoi
10.1007/s10517-013-2278-ysubject
Has Abstractpub_date
2013-11-01 00:00:00pages
63-5issue
1eissn
0007-4888issn
1573-8221journal_volume
156pub_type
杂志文章abstract：:Study of the expression of type IV collagen by Lewis pulmonary carcinoma cells (PLMG-T, PLMG-M1, PLMG-M2) showed that these cells produce type IV collagen. The expression of type IV collagen in PLMG-T and PLMG-M2 cells approximately 2-fold surpassed that in PLMG-M1 cells. The number of active cells (synthesizing type ...
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