Abstract:
:The effect of intravenous transplantation of mesenchymal stem cells on the recovery of cognitive functions was studied in Wistar-Kyoto rats after brain stroke induced by occlusion of the middle cerebral artery in the left hemisphere. Analysis 2 and 5 weeks after stroke showed that transplantation of mesenchymal stem cells 3 days after middle cerebral artery occlusion reduced the area of cerebral injury, preserved cognitive functions, and decreased mortality in experimental animals.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Sokolova IB,Fedotova OR,Zin'kova NN,Kruglyakov PV,Polyntsev DGdoi
10.1007/s10517-006-0405-8subject
Has Abstractpub_date
2006-10-01 00:00:00pages
511-4issue
4eissn
0007-4888issn
1573-8221pii
doijournal_volume
142pub_type
杂志文章abstract::The role of extracellular matrix enzymes in the development of distant metastases of colorectal cancer was studied. The expression of types 2 and 9 matrix metalloproteinases was evaluated in primary colorectal adenocarcinomas (264 patients) and their metastases in the lymph nodes (127 patients) and liver (109 patients...
journal_title:Bulletin of experimental biology and medicine
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doi:10.1007/s10517-009-0507-1
更新日期:2009-03-01 00:00:00
abstract::Human embryonic myogenic precursors were transplanted into muscles of mdx mice with hereditary dystrophin-deficient muscular dystrophy. Transplantation induced the synthesis of human dystrophin. The number of dystrophin-positive fibers progressively decreased, however, some of them were preserved even 5 months after t...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1023/a:1026009517850
更新日期:2003-07-01 00:00:00
abstract::Polymorphic variants of CYP1A2 and CYP2D6 genes of the cytochrome P450 system were studied in patients with schizophrenia with drug-induced motor disorders and hyperprolactinemia against the background of long-term neuroleptic therapy. We revealed an association of polymorphic variant C-163A CYP1A2*1F of CYP1A2 gene w...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-016-3250-4
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abstract::Activities of antioxidant enzymes, vitamin E level, lactate dehydrogenase isoenzyme spectrum, and effects of melatonin on these parameters were studied in the myocardium of rats aged 6, 12, 18, and 24 months exposed to different illumination regimens. The greatest number of changes was recorded in rats exposed to perm...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-010-0945-9
更新日期:2010-09-01 00:00:00
abstract::The relationship between dromotropic and chronotropic components of various cardiac reflexes was studied in cats. Intravenous infusion of blood was mainly accompanied by unidirectional negative chronotropic and dromotropic effects, but the dynamics of these effects was different. Clumping of the carotid arteries in mo...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-008-0041-6
更新日期:2008-02-01 00:00:00
abstract::Noopept, a peptide analog of piracetam, enhanced phagocytic activity of mouse peritoneal macrophages, stimulated humoral and cellular immune response to various antigens, and markedly increased spontaneous proliferative activity of splenocytes. In animals with secondary immune deficiency caused by cyclophosphamide, no...
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pub_type: 杂志文章
doi:10.1007/s10517-007-0251-3
更新日期:2007-07-01 00:00:00
abstract::The effects of intranasal administration of oxytocin on the levels and metabolism of monoamines in symmetrical structures of the brain of white outbred mice kept under conditions of long-term social isolation were studied by HPLC. Disappearance of initial right-sided asymmetry in the content of dopamine metabolites in...
journal_title:Bulletin of experimental biology and medicine
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abstract::Comparative identification of cerebral regions activated in men and women during perception of indefinite images was carried out by fMRT and psychological testing. Nine men and nine women aged 20-26 years took part in the study. The volunteers examined simple geometric figures, slightly structurized images (tables fro...
journal_title:Bulletin of experimental biology and medicine
pub_type: 临床试验,杂志文章
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更新日期:2016-07-01 00:00:00
abstract::Pharmacokinetics of GVS-111, a new acylprolyldipeptide with nootropic properties and its penetration across the blood-brain barrier were studied in rats using HPLC. It was found that the dipeptide is absorbed in the gastrointestinal tract, enters the circulation, and penetrates through the blood-brain barrier in an un...
journal_title:Bulletin of experimental biology and medicine
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abstract::Plasma LDL content increased in rats with mild chronic heart failure, but decreased in animals with severe pathology. The lipid profile of β-adrenoceptor antagonists depended on their selectivity. The most selective antagonists of β-adrenoceptors had little effect on the lipid composition. Nonselective β-adrenoceptor ...
journal_title:Bulletin of experimental biology and medicine
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更新日期:2013-12-01 00:00:00
abstract::Groups of microRNA genes, methylation of which is associated with the initial (I-II) stages of breast cancer, are determined, and new markers and marker systems for the disease diagnosis were created on the basis of these data. A total of 14 genes in which methylation was associated with breast cancer were identified ...
journal_title:Bulletin of experimental biology and medicine
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更新日期:2019-12-01 00:00:00
abstract::Comparative analysis of the parameters of LPO, antioxidant defense (AOD), and the thiol/disulfide system was performed in fertile and infertile males of reproductive age carrying different genotypes of the glutathione system genes. Blood plasma, blood hemolysate, and ejaculate served as specimens for biochemical studi...
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doi:10.1007/s10517-017-3808-9
更新日期:2017-07-01 00:00:00
abstract::Histaminergic contractile reactions of smooth muscles in rabbit lobar pulmonary arteries were studied using in vitro mechanographic technique. Histamine via activation of H-receptors induced a dose-dependent constriction of smooth muscle segments, while endothelium inhibited histamine-induced contractile reactions. Hi...
journal_title:Bulletin of experimental biology and medicine
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abstract::We studied the effect of sodium hydrosulfite (NaHS), a donor of hydrogen sulfide (H2S), on spontaneous contractive activity of isolated preparations of rat stomach and jejunum under isometric conditions. NaHS in concentrations of 10-200 μM reduced the amplitude, tonic tension, and frequency of contractions of the prep...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-014-2551-8
更新日期:2014-07-01 00:00:00
abstract::We studied competitive activities of 16 alpha,17 alpha-cyclohexano-5 alpha- and 5 beta-dihydroprogesterone in replacing(3)H-progesterone and(3)H-16 alpha,17 alpha-cyclohexano-6 alpha-methylprogesterone from protein complexes. Direct binding of(3)H-5-reduced derivatives with proteins of soluble fractions from rat and r...
journal_title:Bulletin of experimental biology and medicine
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journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-013-2200-7
更新日期:2013-08-01 00:00:00
abstract::The fate of human fetal stem/progenitor cells transplanted into rat brain depends on conditions of preculturing (long or short) and state and site of transplantation. Human nestin-positive stem cells cultured according to the short protocol did not migrate into hypoxic and normal brain after transplantation, but activ...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
doi:10.1007/s10517-005-0251-0
更新日期:2005-02-01 00:00:00
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journal_title:Bulletin of experimental biology and medicine
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abstract::Studies of the molecular mechanisms of esophageal cancer development have to be carried out on sufficient amount of tumor material, obtained under conditions of controlled exposure to carcinogenic factors. Esophageal cancer models on laboratory animals serve an indispensable source of this material. One of these model...
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abstract::Changes in bile ducts in cholestasis are characterized by activation of proliferation and hypertrophy of cholangiocytes and degenerative and necrobiotic changes in ductal epithelium. Long-term cholestasis led to massive necrosis of cholangiocytes. Inflammatory changes in the choledochal mucosa were most pronounced in ...
journal_title:Bulletin of experimental biology and medicine
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abstract::The location and activities of nitric oxide synthases in synovial cells during different stages of inflammatory process were studied by the immunocytochemical method in animals with experimental rheumatoid arthritis. Direct involvement of the NOergic mechanisms in the development of adjuvant arthritis was demonstarted...
journal_title:Bulletin of experimental biology and medicine
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更新日期:2017-05-01 00:00:00
abstract::Presentation of visual and acoustic stimuli at a rate of 2-30 Hz modulated variability of the heart rhythm in volunteers. Potentation of vagal influences and a decrease in the contribution of ergotropic systems to the regulation of the heart rate were noted after 10 sessions of audiovisual stimulation. These changes w...
journal_title:Bulletin of experimental biology and medicine
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更新日期:2001-03-01 00:00:00
abstract::We carried out a complex physiological, neurochemical, and neuroimmunologic study of the formation of tolerance to analgetic effect of morphine and analyzed enkephalinase A activity in different brain structures and serotonin antibodies in the serum. More early development of morphine tolerance and a sharp increase in...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
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更新日期:2001-01-01 00:00:00
abstract::Brain pathology (acute hypoxia and posthypoxic encephalopathy) is associated with less pronounced hyperplasia of the bone marrow erythroid stem (due to decreased count of proliferating committed precursors) and hemolytic anemia, while secretory activity of stromal cells of the hemopoiesis-inducing microenvironment is ...
journal_title:Bulletin of experimental biology and medicine
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更新日期:2010-07-01 00:00:00
abstract::Cardiac and plasma activities of marker lysosomal enzymes were studied in Wistar rats with metabolic (epinephrine) and occlusion (ligation of coronary arteries) myocardial infarction. Activity of all examined lysosomal enzymes significantly increased in the myocardium and blood plasma starting from the first day after...
journal_title:Bulletin of experimental biology and medicine
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abstract::The degree of oxygen consumption in rats was determined after intraperitoneal injection of morphine in a single dose of 5 mg/kg. Some animals were injected with morphine and perorally received morphine or antibodies to mu-opiate receptors in ultralow doses obtained by the technology of potentiation. Potentiated substa...
journal_title:Bulletin of experimental biology and medicine
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更新日期:2003-01-01 00:00:00
abstract::Fluorescent granular cells of the thymus lobule containing neurotransmitter monoamines express Ia antigen and S-100 protein, which attests to their macrophage origin; positive staining with aldehyde fuchsin points to secretion of peptide hormones by these cells. These facts and the absence of phagocytic activity allow...
journal_title:Bulletin of experimental biology and medicine
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更新日期:2001-07-01 00:00:00
abstract::Taftsin, an endogenous peptide immunostimulator, exhibits also high antiulcer activity. In a dose of 0.6 micromol/kg Taftsin decreases the area of ulcerative lesions in albino rats on various models of ulceration. ...
journal_title:Bulletin of experimental biology and medicine
pub_type: 杂志文章
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更新日期:2004-08-01 00:00:00