Angiomatosis and ectopic ossification in the dog myocardium after intramyocardial implantation of autologous bone marrow mononuclears in experimental coronary disease.

abstract：:Human embryonic myogenic precursors were transplanted into muscles of mdx mice with hereditary dystrophin-deficient muscular dystrophy. Transplantation induced the synthesis of human dystrophin. The number of dystrophin-positive fibers progressively decreased, however, some of them were preserved even 5 months after t...

journal_title：Bulletin of experimental biology and medicine

authors： Yarygin VN,Sukhikh GT,Sitnikov VF,Stenina MA,Kuznetsov AB,Poltavtseva RA,Krivov LI,Voevodin DA,Savchuk VI,Revishchin AV,Korochkin LI,Aleksandrova MA

更新日期：2003-07-01 00:00:00

abstract：:We studied the effects of cholesterol, its oxidized derivatives mevalonate, and nuclear receptor agonists LXR, RXR, and FXR on the production of transforming growth factor-beta1 (TGF- beta1) by macrophages. After recruiting of macrophage monocytes into the focus of inflammation, the production of TGF-beta1 increased b...

journal_title：Bulletin of experimental biology and medicine

authors： Schwartz YSh,Khoshchenko OM,Dushkin MI,Feofanova NA

更新日期：2009-09-01 00:00:00

abstract：:Changes in the diurnal light cycle affect the morphofunctional state of the pineal gland. The volume of the nucleus, Golgi apparatus, and mitochondria in pinealocytes decreases after 45-day exposure to bright light. After 90 days, the degree of nuclear polymorphism increased, the specific volume of the Golgi apparatus...

journal_title：Bulletin of experimental biology and medicine

authors： Gerasimov AV,Logvinov SV,Kostyuchenko VP

更新日期：2010-12-01 00:00:00

abstract：:We studied the structure of rhythms of BP, HR (by telemetric monitoring), electrolyte excretion (by capillary electrophoresis), and products of epiphyseal melatonin (by the urinary concentration of 6-sulfatoxymelatonin measured by ELISA) in normotensive Wistar-Kyoto rats and spontaneously hypertensive SHR rats maintai...

journal_title：Bulletin of experimental biology and medicine

authors： Blagonravov ML,Bryk AA,Medvedeva EV,Goryachev VA,Chibisov SM,Kurlaeva AO,Agafonov ED

更新日期：2019-11-01 00:00:00

abstract：:We proposed new method for measuring dynamic changes in hunger motivation in rabbits in the course of satisfaction of nutritional need by weight, time, and rate parameters of effective food-procuring behavior. Transformation of the amount of food eaten into the electric signals was performed using electronic weighing ...

journal_title：Bulletin of experimental biology and medicine

authors： Dvoenko EE,Kromin AA,Maslov AN

更新日期：2012-05-01 00:00:00

abstract：:Behavioral responses of 90-day-old male offspring from female Wistar rats exposed to restraint stress during the last week of pregnancy were studied in the formalin test. Specific biphasic behavioral response characterized acute (phase 1) and persistent tonic pain (phase 2). The intensity of nociceptive responses (eva...

journal_title：Bulletin of experimental biology and medicine

authors： Butkevich IP

更新日期：2002-02-01 00:00:00

abstract：:We studied the effect of constant illumination for 1 month on female GC (genetic catalepsy) and Wistar rats (control). Light exposure decreased the degree of cataleptic freezing in female GC rats (compared to the control). Norepinephrine concentration in cataleptic rats returned to normal under these conditions: this ...

journal_title：Bulletin of experimental biology and medicine

authors： Klotchkov DV,Alekhina TA,Ukolova TN,Rjazanova MA

更新日期：2008-07-01 00:00:00

abstract：:Our findings indicate that expression of matrix metalloproteinase-2 is an important prognostic marker of invasive potential of pancreatic tumors. Expression of this marker in neuroendocrine tumors (particularly in gastrinomas) can be used as a differential diagnostic criterion characterizing more malignant phenotype o...

journal_title：Bulletin of experimental biology and medicine

authors： Gurevich LE

更新日期：2003-11-01 00:00:00

abstract：:Histaminergic contractile reactions of smooth muscles in rabbit lobar pulmonary arteries were studied using in vitro mechanographic technique. Histamine via activation of H-receptors induced a dose-dependent constriction of smooth muscle segments, while endothelium inhibited histamine-induced contractile reactions. Hi...

journal_title：Bulletin of experimental biology and medicine

authors： Kapilevich LV,Anfinogenova YD,Nosarev AV,Baskakov MB,Kovalev IV,D'yakova EY,Medvedev MA

更新日期：2001-08-01 00:00:00

abstract：:Nadcin in a dose of 90 mg/kg administered to dogs with subacute stage of ischemia-reperfusion myocardial injury immediately after blood flow resumption normalized redox potential of cardiomyocytes and mitochondria and restored the total content of adenyl and pyridine nucleotides. The decrease in the synthesis of ATP a...

journal_title：Bulletin of experimental biology and medicine

authors： Sukoyan GV,Kavadze IK

更新日期：2008-09-01 00:00:00

abstract：:Angiogenic action of compound GK-2, a dimeric dipeptide mimetic of loop 4 of nerve growth factor (NGF), was studied in in vitro and in vivo experiments. Experiments on human endothelial cell culture HUVEC showed that compound GK-2 significantly (p<0.05) stimulated the initial stage of angiogenesis, and its angiogenic ...

journal_title：Bulletin of experimental biology and medicine

authors： Kryzhanovskii SA,Antipova TA,Tsorin IB,Pekeldina ES,Stolyaruk VN,Nikolaev SV,Sorokina AV,Gudasheva TA,Seredenin SB

更新日期：2016-08-01 00:00:00

abstract：:NAD, cytochrome c, and energostim modulated the fluorescence emission spectrum of trifluoperazine in the solution and in microsomal suspension. The data suggest that NAD and energostim modify structural and conformational characteristics of the dopamine receptor-trifluoperazine complex. These changes probably underlie...

journal_title：Bulletin of experimental biology and medicine

authors： Chikobava EA,Galenko-Yaroshevskii PA,Gurskaya EV,Mamuchishvili IG,Sukoyan GV

更新日期：2004-03-01 00:00:00

abstract：:Preliminary injection of succinic semialdehyde into animals in experiments with hypoxia led to a lower concentration of free ammonia in their brain tissues than in control experiments in which the compound was not given. The enzyme system of the liver tissue catalyzes the oxidation of NAD-H-2 by succinic semialdeyde a...

journal_title：Bulletin of experimental biology and medicine

authors： Zubovskaya AM,Ostrovskaya RU,Tsybina NM

更新日期：1975-01-01 00:00:00

abstract：:We studied the possibility of reproducing syringomyelia in rabbits by injection of serum from patients with syringomyelia. Clinical signs of syringomyelia and morphological changes in the central nervous system (cavities, dilatation of the cerebrospinal channel, neurodegeneration, gliosis) developed in laboratory anim...

journal_title：Bulletin of experimental biology and medicine

authors： Mirsayev TR,Borisova NA

更新日期：2007-04-01 00:00:00

abstract：:We studied the effect of carbon monoxide (60-, 75-, and 90-min exposure) on the expression of antiapoptotic proteins (survivin and Bcl-2) in human blood lymphocytes in the presence of recombinant IL-2 in an apoptosis-inducing dose (0.1 ng/ml). Incubation of cells in atmosphere with carbon monoxide in the presence of r...

journal_title：Bulletin of experimental biology and medicine

authors： Artyukhov VG,Tyunina OI

更新日期：2017-01-01 00:00:00

abstract：:The time course of drug adsorption and desorption, exposure of soft contact lenses in a drug solution needed for maximum saturation, and the duration of lens wearing during which the drug was transported from the lens and exhibited its therapeutic activity were studied. The possibility of using computer simulation for...

journal_title：Bulletin of experimental biology and medicine

authors： Zhilyakova ET,Novikov OO,Akopova VV

更新日期：2013-12-01 00:00:00

abstract：:More than 70% malignant mammary tumors contain steroid hormone receptors; this suggests the possibility of hormone therapy in the majority of patients with breast cancer (BC). The main cause of inefficiency of hormone therapy in BC is hormone resistance (tumor resistance to hormonal cytostatics). Here we discuss the m...

journal_title：Bulletin of experimental biology and medicine

authors： Scherbakov AM,Krasil'nikov MA,Kushlinskii NE

更新日期：2013-07-01 00:00:00

abstract：:The efficiency of drug therapy should be evaluated by not only its directed action on specific organ or target parameter, but also its effects on general regulatory and adaptive status. ...

journal_title：Bulletin of experimental biology and medicine

authors： Pokrovskii VM,Kompaniets OG

更新日期：2008-06-01 00:00:00

abstract：:We studied the phospholipid composition of high-density lipoproteins in patients with hypercholesterolemia before and after treatment with simvastatin. Individual phospholipids were separated by thin-layer chromatography on glass plates coated with silica gel. It was found that apart from hypolipidemic effect, simvast...

journal_title：Bulletin of experimental biology and medicine

authors： Ozerova IN,Paramonova IV,Olfer'ev AM,Akhmedzhanov NM,Aleksandrova MA,Perova NV

更新日期：2001-08-01 00:00:00

abstract：:A direct relationship between the weights of the brain and hemisphere and parameters characterizing the development of the cortex and its neurons in intact newborn rats was revealed. Parameters of brain development in newborn rats correlate with 3beta-hydroxysteroid dehydrogenase activity in the adrenal zona glomerulo...

journal_title：Bulletin of experimental biology and medicine

authors： Ryzhavskii BY,Matveeva EP,Baranova SN

更新日期：2005-12-01 00:00:00

abstract：:Threefold administration of benz(a)pyrene in a dose of 20 mg/kg markedly stimulated biliary excretion of lysosomal enzymes from rat liver without signs of lysosomal damage. Constant light exposure induced changes attesting to functional activation of the lysosomal apparatus in liver cells and inhibited constitutive bi...

journal_title：Bulletin of experimental biology and medicine

authors： Pupyshev AB,Gutina EM,Fedina RG,Michurina SV,Shurlygina AV,Verbitskaya LV

更新日期：2005-01-01 00:00:00

abstract：:We evaluated the concentration dependence and time dependence of the effect of nitroglycerine on intracellular content of cAMP, cGMP, and free Ca2+. It was shown that after norepinephrine stimulation, nitroglycerine exhibited calcium-blocking activity in lower concentrations (starting from 10(-7) M). Under conditions ...

journal_title：Bulletin of experimental biology and medicine

authors： Dukhanin AS,Shimanovskii NL

更新日期：2006-05-01 00:00:00

abstract：:We studied the effect of turmeric extract in the composition of rectal suppositories on the level of LPO products and oxidative modification of proteins in the colon mucosa of Wistar rats with experimental Crohn's disease modeled by rectal administration of trinitrobenzenesulfonic acid. The suppositories containing tu...

journal_title：Bulletin of experimental biology and medicine

authors： Osikov MV,Simonyan EV,Bakeeva AE,Ogneeva OI

更新日期：2020-07-01 00:00:00

abstract：:We studied the peculiarities of oxidative and substrate phosphorylation in isolated cardiomyocytes and myocardial mitochondria in 2- and 15-month-old rats. It was shown that age factor reduces the degree of oxidation and phosphorylation coupling both in cardiomyocytes and in mitochondria, which was associated with the...

journal_title：Bulletin of experimental biology and medicine

authors： Tsapko LP,Afanas'ev SA

更新日期：2019-08-01 00:00:00

abstract：:The prooxidant-antioxidant balance in rats with oxidative stress was studied during correction of the L-arginine-NO system. Oxidative stress was induced by intravenous injection of E. coli lipopolysaccharide. Under conditions of oxidative stress the prooxidant-antioxidant imbalance was least pronounced during selectiv...

journal_title：Bulletin of experimental biology and medicine

authors： Glebov AN,Zinchuk VV

更新日期：2006-04-01 00:00:00

abstract：:The effect of intravenous transplantation of mesenchymal stem cells on the recovery of cognitive functions was studied in Wistar-Kyoto rats after brain stroke induced by occlusion of the middle cerebral artery in the left hemisphere. Analysis 2 and 5 weeks after stroke showed that transplantation of mesenchymal stem c...

journal_title：Bulletin of experimental biology and medicine

authors： Sokolova IB,Fedotova OR,Zin'kova NN,Kruglyakov PV,Polyntsev DG

更新日期：2006-10-01 00:00:00

abstract：:Plasma LDL content increased in rats with mild chronic heart failure, but decreased in animals with severe pathology. The lipid profile of β-adrenoceptor antagonists depended on their selectivity. The most selective antagonists of β-adrenoceptors had little effect on the lipid composition. Nonselective β-adrenoceptor ...

journal_title：Bulletin of experimental biology and medicine

authors： Sidorov AV

更新日期：2013-12-01 00:00:00

abstract：:In rat sinoatrial node, NAD(+) (10 μM) reduced the rate of spontaneous action potentials, duration of action potentials, and the velocity of slow diastolic depolarization, but the rate of action potential front propagation increases. In passed rabbit Purkinje fibers, NAD(+) (10 μM) reduced the duration of action poten...

journal_title：Bulletin of experimental biology and medicine

authors： Pustovit KB,Kuz'min VS,Sukhova GS

更新日期：2015-06-01 00:00:00

abstract：:Parameters of cardiac activity after administration of the cholinesterase inhibitor physostigmine were analyzed in newborn rats and on day 16 of postnatal development. The type of cardiovascular response to acetylcholine excess in newborns and 16-day-old rats were similar, but they significantly differed by the magnit...

journal_title：Bulletin of experimental biology and medicine

authors： Sizonov VА,Dmitrieva LE

更新日期：2018-05-01 00:00:00

abstract：:Plasma cytokine concentration in patients with Parkinson's disease and mutation in GBA gene, in patients with sporadic Parkinson's disease, and in healthy volunteers were measured by ELISA and multiplex analysis. In patients with Parkinson's disease and mutation in GBA gene, elevated plasma concentrations of IL-1β and...

journal_title：Bulletin of experimental biology and medicine

authors： Miliukhina IV,Usenko TS,Senkevich KA,Nikolaev MA,Timofeeva AA,Agapova EA,Semenov AV,Lubimova NE,Totolyan AA,Pchelina SN

更新日期：2020-02-01 00:00:00