Abstract：
:We studied the effects of cholesterol, its oxidized derivatives mevalonate, and nuclear receptor agonists LXR, RXR, and FXR on the production of transforming growth factor-beta1 (TGF- beta1) by macrophages. After recruiting of macrophage monocytes into the focus of inflammation, the production of TGF-beta1 increased by 3.5 times in comparison with control macrophages. Cholesterol diet stimulated the production of TGF-beta1 by 2.5 times. Cholesterol directly stimulated macrophage production of TGF-beta1 in vitro, while addition of mevalonate to the incubation medium effectively reduced this induced production. Agonists of nuclear receptor sharply reduced the production of TGF-beta1 in recruited macrophages. Under conditions of inflammation, hypercholesterolemia can be a factor of fibrogenesis due to TGF-beta1 induction in macrophages, which depends on the products of mevalonate biochemical chain.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Schwartz YSh,Khoshchenko OM,Dushkin MI,Feofanova NAdoi
10.1007/s10517-010-0724-7subject
Has Abstractpub_date
2009-09-01 00:00:00pages
406-9issue
3eissn
0007-4888issn
1573-8221journal_volume
148pub_type
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