Dynamics of behavioral disorders in transgenic mice with modeled Alzheimer's disease.

Abstract:

:Age-related development of behavioral disorders in transgenic mice with modeled Alzheimer's disease carrying V6S3-Tg(APP695)85Dbo Tg(PSENI)85Dbo) genotype was assessed at the age of 7.5, 10 and 20 months in the following tests: open-field, plus maze, T-maze, conditioned passive avoidance response, rotarod, conflict situation with water deprivation, behavioral despair, and arecoline tremor. The main behavioral disorder in transgenic mice at all observation terms was memory impairment in conditioning with positive (but not negative) reinforcement. At the age of 7.5 and 10 months, transgenic mice also showed signs of nonspecific excitement and anxiety, depression-like state, and symptoms of cholinergic deficit. Our results suggest that appropriate age for behavioral tests in studies of effects of potential anti-Alzheimer drugs in transgenic V6S3-Tg(APP695)85Dbo Tg(PSENI)85Dbo) mice is 7.5-10 months.

journal_name

Bull Exp Biol Med

authors

Semina II,Baichurina AZ,Makarova EA,Leushina AV,Kazakevich ZhV,Gabdrakhmanova MR,Mukhamed'yarov MA,Zefirov AL

doi

10.1007/s10517-015-2821-0

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

621-3

issue

5

eissn

0007-4888

issn

1573-8221

journal_volume

158

pub_type

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