Abstract:
:Voltage clamp and concentration jump experiments performed on Purkinje cells isolated from rat cerebellum showed that novel imidazobenzoimidazole derivative RU-353 increased the amplitude of GABA-activated chlorine current in a dose-dependent manner (EC50=15 microM for the currents activated by 1 microM GABA). RU-353 shifted the GABA dose-response curve to the left, but produced no effect on the maximum response (EC50 in control and in the presence of 30 microM RU-353 were 6.9 and 2.0 microM, respectively).
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Sharonova NI,Vorob'ev VS,Skrebitskii VG,Galenko-Yaroshevskii AP,Turovaya AY,Anisimova VAdoi
10.1007/s10517-005-0481-1subject
Has Abstractpub_date
2005-09-01 00:00:00pages
326-9issue
3eissn
0007-4888issn
1573-8221pii
doijournal_volume
140pub_type
杂志文章abstract::Administration of granulocyte CSF preparation to patients with chronic heart failure produced a hemostimulating effect and increased the content of leukocytes and neutrophils in the peripheral blood. Granulocyte CSF induced mobilization of bone marrow progenitor cells into the peripheral blood. The content of hemopoie...
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