Abstract：
:The involvement of PI3K, ERK and p38-dependent signaling system in the regulation of functional activity of erythroid precursors after blood loss (30% of circulating volume) was studied. We demonstrated the important role of PI3K and p38 in the suppression of differentiation of erythroid precursors the contribution of p38 to stimulation of mitotic activity of erythroid CFU, which maintains the growth potential of the precursors at the optimal physiological level. The classical MAPK/ERK-kinase pathway does not determine the proliferative and differentiation status of erythroid CFU.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Dygai AM,Zhdanov VV,Miroshnichenko LA,Udut EV,Zyuz'kov GN,Simanina EV,Sherstoboev EY,Chaikovskii AV,Stavrova LA,Burmina YV,Khrichkova TY,Reichart DV,Goldberg VEdoi
10.1007/s10517-015-2775-2subject
Has Abstractpub_date
2015-02-01 00:00:00pages
417-20issue
4eissn
0007-4888issn
1573-8221journal_volume
158pub_type
杂志文章abstract：:Hepatoprotective activity of pyrimidine derivative hydroxymethyluracil was studied on the model of acute paracetamol-induced liver damage in rats. Hydroxymethyluracil was shown to produce a strong hepatoprotective effect. ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-007-0183-y
更新日期：2007-05-01 00:00:00
abstract：:Quantitative assay of nitric oxide (NO) and iron (Fe) was carried out by the electron paramagnetic resonance (EPR) method in epidermal derivative (hair) of 45 liquidators of the Chernobyl accident, 30 employees of radiological institutions having contact with radiation, and 50 students of Vladimir State University, mo...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-013-2042-3
更新日期：2013-04-01 00:00:00
abstract：:Data are presented on chemical study of flavonoid glycosides in some botanical subjects using matrix-assisted laser desorption ionization, compared to HPLC. The method of matrix-assisted laser desorption ionization (MALDI) allows characterizing the composition of anthocyanin and flavonoid mixture without preliminary s...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-013-1960-4
更新日期：2013-01-01 00:00:00
abstract：:We performed immunohistochemical analysis of the expression of TGFβ, galectin-1, vimentin, and thrombospondin in the mucosa in gastric cancer of diffuse and intestinal type associated with systemic undifferentiated connective tissue dysplasia. In diffuse gastric cancer, both with and without association with connectiv...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-019-04438-8
更新日期：2019-04-01 00:00:00
abstract：:We studied the seasonal effects of peptide preparation Selank on orientation and exploratory activity in 36 arctic ground squirrels Citellus undulatus in the open-field and hole-board tests. Selank most significantly increased behavioral activity of hibernating animals in the spring and fall. The test peptide had no e...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-006-0060-0
更新日期：2005-12-01 00:00:00
abstract：:We studied the effect of transfection of PC-3 prostate cancer cells with a plasmid encoding shRNA complimentary to a fragment of integrin β4 (ITGB4). The results attest to considerable changes in the transcriptome of transfected cells. For instance, compensatory changes in the expression of integrin family genes were ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-015-3011-9
更新日期：2015-08-01 00:00:00
abstract：:The effects of intranasal administration of oxytocin on the levels and metabolism of monoamines in symmetrical structures of the brain of white outbred mice kept under conditions of long-term social isolation were studied by HPLC. Disappearance of initial right-sided asymmetry in the content of dopamine metabolites in...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-017-3887-7
更新日期：2017-10-01 00:00:00
abstract：:Oxidative status was assessed in different areas of the cerebral cortex of male Wistar rats under normal condition and during permanent 24-h focal ischemia. In intact animals, the level of lipid hydroperoxides in the frontal lobes of both hemispheres was by 36% higher than in other cortical areas, while total antioxid...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-018-4256-x
更新日期：2018-10-01 00:00:00
abstract：:Parameters of cardiac activity after administration of the cholinesterase inhibitor physostigmine were analyzed in newborn rats and on day 16 of postnatal development. The type of cardiovascular response to acetylcholine excess in newborns and 16-day-old rats were similar, but they significantly differed by the magnit...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-018-4095-9
更新日期：2018-05-01 00:00:00
abstract：:The content of phospholipids in various tissues was studied during synergistic interaction between two branches of the autonomic nervous system. We found higher myocardial content of choline-containing phospholipids and lower rigidity of erythrocyte membranes in rabbits with pronounced sympathetic potentiation of the ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/a:1016203713719
更新日期：2002-04-01 00:00:00
abstract：:Digital simulation of disorders in the p53 and Mdm2 protein system, involved in repair of DNA defects and in many vital processes, including tumor formation, neurodegeneration, and aging, was carried out on the base of functional nonlinear octoparametric mathematical model. Stress situations were studied, associated w...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-014-2608-8
更新日期：2014-08-01 00:00:00
abstract：:Non-pulsed optical density of the small intestine was studied in 32 dogs and the results were compared with the data of angiotensometry and pulsomotorography. New regularities of blood circulation in the small intestine were detected: more than half of the total volume specific blood flow in the intestinal tissue is n...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/b:bebm.0000017113.42880.97
更新日期：2003-11-01 00:00:00
abstract：:We measured the content of glutathione and activity of glutathione-metabolizing and antioxidant enzymes superoxide dismutase and catalase in samples obtained from 52 patients with malignant lung tumors and 20 patients with benign lung tumors. The content of glutathione and activity of glutathione-metabolizing enzymes ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/a:1020206514239
更新日期：2002-06-01 00:00:00
abstract：:Changes in the muscular tissue after subcutaneous injection of autologous bone marrow multipotent mesenchymal stromal cells transfected with GFP gene and additionally stained with cell membrane dye Vybrant CM-Dil in the projection of ligated femoral vein were studied by light microscopy with luminescence. Stromal cell...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-018-4031-z
更新日期：2018-03-01 00:00:00
abstract：:Serum activity of tartrate-resistant acid phosphatase 5b (TRAP 5b) in patients with breast cancer and prostate cancer having bone metastases was much higher than in healthy donors and patients without skeletal injuries. TRAP 5b activity in patients with breast cancer and multiple bone metastases surpassed that in pati...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/b:bebm.0000046945.95479.d6
更新日期：2004-07-01 00:00:00
abstract：:Regeneratory activities of Baikal aconite alkaloids were studied on the excision skin wound model. Manifest wound healing effects of songorine, napelline, and hypaconitine were detected. The therapeutic efficiency was based on activation of residual mesenchymal progenitor elements. The development of this phenomenon w...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：
更新日期：2012-10-01 00:00:00
abstract：:We carried out a retrospective immunohistochemical study of Ki-67, PCNA, Bcl-2, BAX, BclX, and VEGF expression in tumors of two groups of breast cancer patients with favorable and unfavorable course of the disease. Considerably enhanced VEGF expression was detected in tumors of patients with early relapses of breast c...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/b:bebm.0000028135.91289.e9
更新日期：2004-02-01 00:00:00
abstract：:Blood flow in reproductive organs was studied during experimental cessation of blood outflow in the testicular vein. This pathological state was accompanied by disturbances of the complex pathogenesis. The major component was autoregulatory focal ischemia, which resulted from the venoarterial response to venous hypert...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-007-0213-9
更新日期：2007-06-01 00:00:00
abstract：:The micronucleus test was used tu study the possibility of inducing cross-adaptive response in mouse bone marrow cells in vivo with an 850 nm infrared light modulated by a 101 Hz frequency, emitted by a light therapy device "Kurator". We demonstrated that this exposure led to a substantial reduction of cytogenetic cel...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-009-0522-2
更新日期：2009-04-01 00:00:00
abstract：:Fluorescent granular cells of the thymus lobule containing neurotransmitter monoamines express Ia antigen and S-100 protein, which attests to their macrophage origin; positive staining with aldehyde fuchsin points to secretion of peptide hormones by these cells. These facts and the absence of phagocytic activity allow...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/a:1012552917439
更新日期：2001-07-01 00:00:00
abstract：:The effects of glucocorticoids on monocyte morphology and function in vitro and the results of high-dose budesonide therapy in patients with non-severe bronchial asthma were analyzed. Before therapy with inhalation glucocorticosteroid (budesonide) characteristics of blood monocytes and the effects of different concent...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/a:1025489604819
更新日期：2003-06-01 00:00:00
abstract：:The safety of combined administration of ultralow doses of antigens to endothelial NO synthase (impaza) and nitrates for the treatment of erectile dysfunction in CHD patients was evaluated in an open non-comparative clinical trial. The efficiency and safety of impaza and the possibility of its administration to patien...
journal_title：Bulletin of experimental biology and medicine
pub_type： 临床试验,杂志文章
doi：10.1007/s10517-009-0688-7
更新日期：2009-08-01 00:00:00
abstract：:The study compared the effects of phytococktail Bioritm-E (a multicomponent phytoadaptogen) and experimental preparation Skvaakan from the liver of Black Sea spurdog on systemic homeostasis, microcirculation, and blood lipid profile in 15 days of their daily administration. Skvaakan enhanced the platelet activity prod...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-012-1917-z
更新日期：2012-12-01 00:00:00
abstract：:The inotropic response of the myocardium to extrasystolic treatment was studied on isolated perfused papillary muscles from rats with postinfarction cardiosclerosis. The development of postinfarction cardiosclerosis was accompanied by a decrease in myocardial excitability. The amplitude of extrasystolic contractions i...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-005-0367-2
更新日期：2005-06-01 00:00:00
abstract：:Activities of enzymes of active oxygen forms detoxication and phase II xenobiotic metabolism were measured in rat hepatoma 27 cells transplanted to different organs. Activity of phase II xenobiotic metabolizing enzymes was higher in hepatoma cells growing subcutaneously than in those transplanted into the liver, while...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：
更新日期：2000-11-01 00:00:00
abstract：:The second author's name should read A. Yu. Romanov. ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章,已发布勘误
doi：10.1007/s10517-018-4152-4
更新日期：2018-06-01 00:00:00
abstract：:We studied a biomaterial for a new domestic product, a biological envelope for implantation of cardiac electronic devices. The product is designed to prevent complications after pacemaker implantation and to facilitate the reimplantation procedure. By chemical and biological processing of raw materials (submucosa of p...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-020-04712-0
更新日期：2020-01-01 00:00:00
abstract：:The hypolipidemic effect of Kwai, a preparation based on garlic powder (Allium sativum), depended on the initial content of cholesterol and/or triglycerides. This effect was most pronounced in patients with coronary heart disease with initial cholesterol >7.0 mmol/liter and triglyceride >1.92 mmol/liter. After treatme...
journal_title：Bulletin of experimental biology and medicine
pub_type： 临床试验,杂志文章
doi：10.1023/a:1024955023300
更新日期：2003-05-01 00:00:00
abstract：:We studied the influence of high-fat diet on the development of metabolic syndrome in rats of hypertensive ISIAH strain and normotensive WAG strain. In contrast to ISIAH rats, high-fat diet in WAG rats led visceral obesity, glucose tolerance, and dyslipidemia. DNA-binding activity of the peroxisome proliferator-activa...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-014-2417-0
更新日期：2014-03-01 00:00:00
abstract：:We studied the effect of adrenal cortex hormone dehydroepiandrosterone sulfate on maturation and functional activity of interferon-alpha-induced dendritic cells. Dehydroepiandrosterone sulfate stimulated differentiation and maturation of interferon-alpha-induced dendritic cell, which manifested in a decrease in the nu...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-009-0619-7
更新日期：2009-07-01 00:00:00
