Abstract：
:We studied a biomaterial for a new domestic product, a biological envelope for implantation of cardiac electronic devices. The product is designed to prevent complications after pacemaker implantation and to facilitate the reimplantation procedure. By chemical and biological processing of raw materials (submucosa of porcine small intestine), an acellular extracellular collagen matrix was obtained. The biocompatibility of the material was tested in vitro using stem cell cultures. The biomaterial for fabrication of the envelope is not cytotoxic, biocompatible, and represents a suitable substrate for attachment, growth, and reproduction of stem cells. The biological effect of the material was studied in vivo on the model of heterotopic implantation in small laboratory animals. The biomaterial did not induce inflammation and tissue reaction and was completely transformed into healthy vascularized tissue without scars in 90 days after implantation.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Shadrina DV,Venediktov AA,Evdokimov SV,Vaskovskii VA,Artyukhina EA,Revishvili AS,Durmanov SS,Bazylev VVdoi
10.1007/s10517-020-04712-0subject
Has Abstractpub_date
2020-01-01 00:00:00pages
375-377issue
3eissn
0007-4888issn
1573-8221pii
10.1007/s10517-020-04712-0journal_volume
168pub_type
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