Abstract：
:We studied the effect of single intraperitoneal treatment with antibodies to glutamate on pentylenetetrazole-induced acute generalized epileptiform activity in C57Bl/6 mice. The antiepileptic effect was observed 1.5 and 24 h after administration of antibodies to glutamate in doses of 10, 25, and 50 mg/kg. This treatment increased the thresholds of clonic seizures and tonic phase of seizures with lethal outcome.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Evseev VA,Karpova MN,Vetrile LA,Klishina NY,Kuznetsova LV,Trekova NAdoi
10.1007/s10517-005-0471-3subject
Has Abstractpub_date
2005-09-01 00:00:00pages
295-7issue
3eissn
0007-4888issn
1573-8221pii
doijournal_volume
140pub_type
杂志文章abstract：:Enzyme immunoassay of the serum neurospecific antigens (gliofibrillar acid protein and neurospecific enolase) was used for evaluation of the resistance of the blood-brain barrier in Wistar rats with perinatal hypoxia and ischemia of the CNS. Perinatal hypoxia and ischemia of the CNS was modeled by two methods: ligatio...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/b:bebm.0000008978.27644.4b
更新日期：2003-09-01 00:00:00
abstract：:We studied the reaction of the microglia of the anterior horns of the rat spinal cord to intraperitoneal administration of bacterial LPS. Immunohistochemical analysis showed that acute systemic inflammation leads to activation of more than half of microglial cells as soon as in 24 h after LPS injection, while the tota...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-017-3841-8
更新日期：2017-08-01 00:00:00
abstract：:Melatonin administered to intact animals increased glutathione concentration and activities of glutathione peroxidase, glutathione reductase, NADP-isocitrate dehydrogenase, and glucose-6-phosphate dehydrogenase in the liver. In animals with toxic hepatitis melatonin treatment decreased glutathione concentration and en...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-005-0346-7
更新日期：2005-05-01 00:00:00
abstract：:The prooxidant-antioxidant balance in rats with oxidative stress was studied during correction of the L-arginine-NO system. Oxidative stress was induced by intravenous injection of E. coli lipopolysaccharide. Under conditions of oxidative stress the prooxidant-antioxidant imbalance was least pronounced during selectiv...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-006-0178-0
更新日期：2006-04-01 00:00:00
abstract：:The rate and strength of heart contractions decreased after 10-min perfusion of rat myocardium with Krebs-Henseleit solution containing a selective cannabinoid receptor agonist HU-210 in a final concentration of 10 nM. HU-210 completely blocked the positive inotropic and chronotropic effect of beta-adrenoceptor agonis...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-005-0123-7
更新日期：2004-12-01 00:00:00
abstract：:More than 70% malignant mammary tumors contain steroid hormone receptors; this suggests the possibility of hormone therapy in the majority of patients with breast cancer (BC). The main cause of inefficiency of hormone therapy in BC is hormone resistance (tumor resistance to hormonal cytostatics). Here we discuss the m...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-013-2160-y
更新日期：2013-07-01 00:00:00
abstract：:Results of long-term prospective follow-up of patients with early stages of mitral and aortic valvulitis and primary chronic septic endocarditic are presented. Clinical diagnostics of the diseases is described and the key role is assigned to pathognomic (absolute) clinical symptoms. The tendency to progressive fibrosi...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-015-2878-9
更新日期：2015-05-01 00:00:00
abstract：:Local injection of 4 nmol moxonidine (unilaterally) into the rostroventrolateral medulla of spontaneously hypertensive rats (SHR-SP) decreased mean blood pressure and heart rate by 24+/-3 and 3+/-4%, respectively. Pretreatment with the I1/alpha2-receptor antagonist efaroxan abolished the moxonidine-induced decrease in...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/a:1017943901070
更新日期：2001-04-01 00:00:00
abstract：:Plasma cytokine concentration in patients with Parkinson's disease and mutation in GBA gene, in patients with sporadic Parkinson's disease, and in healthy volunteers were measured by ELISA and multiplex analysis. In patients with Parkinson's disease and mutation in GBA gene, elevated plasma concentrations of IL-1β and...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-020-04723-x
更新日期：2020-02-01 00:00:00
abstract：:In August rats more resistant to acute stress-induced gastric damage than Wistar rats, preadaptation to nondamaging stress exposure did not prevent damage and even potentiated these damages. By contrast, in Wistar rats such adaptation decreased gastric damage caused by acute stress. Higher initial resistance of August...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/a:1021987626693
更新日期：2002-10-01 00:00:00
abstract：:Pial arteries of different diameter were studied in intact rats and after 6-month modeling of chronic tobacco smoking in rats. Expression of tachykinin NK1 receptors in pial arteries was studied by biomicroscopy and immunohistochemical methods. Chronic tobacco smoking induced considerable reorganizations of the arteri...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-017-3792-0
更新日期：2017-07-01 00:00:00
abstract：:The location and activities of nitric oxide synthases in synovial cells during different stages of inflammatory process were studied by the immunocytochemical method in animals with experimental rheumatoid arthritis. Direct involvement of the NOergic mechanisms in the development of adjuvant arthritis was demonstarted...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-007-0203-y
更新日期：2007-05-01 00:00:00
abstract：:The effects of cerivastatin on antiatherogenic properties of high-density lipoproteins were studied in patients with coronary heart disease and hyperlipidemia. Apart from hypolipidemic effects, cerivastatin changed the phospholipid composition of high-density lipoproteins and improved their cholesterol-acceptor proper...
journal_title：Bulletin of experimental biology and medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2000-10-01 00:00:00
abstract：:The C-terminal fragment Pro-Gly-Pro of semax does not modulate the development of symptoms of neurological deficiency and mortality in rats with incomplete global cerebral ischemia. Hence, previously revealed neuroprotective effects of semax are mainly determined by corticotropin ACTH4-7 fragment. ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-005-0311-5
更新日期：2005-04-01 00:00:00
abstract：:We studied the effects of blockade of nicotinic receptors in sympathetic and parasympathetic ganglia (hexamethonium), muscarinic receptors (atropine), and beta1-adrenoceptors (atenolol) on arrhythmogenic activity of endothelin-1 during inhibition of nitric oxide synthesis with Nomega-nitro-L-arginine in NMRI mice. Atr...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/b:bebm.0000028115.53995.e0
更新日期：2004-02-01 00:00:00
abstract：:We studied the effect of succinic acid on the process of glucuronidation of 2-ethyl-6-methyl-3-hydroxypyridine after peroral and intraperitoneal administration in the form of succinate or a base. Since the basic form of 2-ethyl-6-methyl-3-hydroxypyridine is insoluble in water, it was administered in 5% Tween-80. It wa...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-008-0205-4
更新日期：2008-07-01 00:00:00
abstract：:Lipemia modeled by injections of Triton WR-1339 (500 mg/kg) and poloxamer 407 (500 mg/kg) to mice were compared. LP fraction and subfraction compositions were compared by small-angle X-ray scattering on a diffractometer. Both compounds in the same dose caused a sharp increase in serum concentrations of total cholester...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-013-2133-1
更新日期：2013-06-01 00:00:00
abstract：:Regeneratory activities of Baikal aconite alkaloids were studied on the excision skin wound model. Manifest wound healing effects of songorine, napelline, and hypaconitine were detected. The therapeutic efficiency was based on activation of residual mesenchymal progenitor elements. The development of this phenomenon w...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：
更新日期：2012-10-01 00:00:00
abstract：:Chronic intranasal administration of fibrillar structures of proinflammatory S100A9 protein impaired passive avoidance learning in old C57Bl/6 mice. Combined treatment with S100A9 fibrils and antibodies to glutamate was followed by an increase in horizontal locomotor activity of animals in the open-field test and did ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-017-3632-2
更新日期：2017-02-01 00:00:00
abstract：:We studied the correlation between the rank and age of baboons (n=12) with their cognitive abilities. A positive correlation was found between performances of different tests by male. The ability to solve the tests related to bait placement depended on the age of the males and age-related hierarchical status. Four-yea...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-018-4201-z
更新日期：2018-08-01 00:00:00
abstract：:Antileprosy activity of dialkyldithiocarbamate derivatives was studied in experiments on mice infected with M. leprae into paw pads. We found that 2-diethyldithiocarbamoyl-3-cyano-5-nitropyridine is the most promising antileprosy agent; it effectively suppresses multiplication of M. leprae and is well tolerated under ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-008-0114-6
更新日期：2008-04-01 00:00:00
abstract：:Interleukin-1beta mRNA, interleukin-1beta receptor mRNA, and erythropoietin receptor mRNA are expressed in the brain of (CBAxC57Bl)F1 mice. Immunization with sheep erythrocytes stimulated the expression of these cytokines in the cerebral hemispheres. Injection of recombinant erythropoietin reduced expression of interl...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/a:1015112729103
更新日期：2002-01-01 00:00:00
abstract：:In the myocardium and skeletal muscles of rats deprived of food for 2 days, basal activity of adenylate cyclase decreased, while the sensitivity of adenylate cyclase signaling system to the stimulating effects of non-hormonal agents (guanine nucleotides and NaF) and beta-agonist isoproterinol modulating adenylate cycl...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-007-0241-5
更新日期：2007-07-01 00:00:00
abstract：:Maximum magnetic resonance artifacts from stents are often determined by the presence of ferromagnetic compounds in the delivery system. We propose a mathematic model describing artifacts caused by nitinol stents. A method for evaluation of critical radial rigidity of the stents was developed. ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-007-0356-8
更新日期：2007-09-01 00:00:00
abstract：:Hemopoietic islets, associations of stromal (macrophages, fibroblasts) and blood (including stem) cells, are structural and functional units of the bone marrow. We studied cellular and molecular processes developing following short-term (1 h) contact of hemopoietic islets with ferromagnetic nanoparticles in a multicel...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-011-1360-6
更新日期：2011-08-01 00:00:00
abstract：:Preparations of I(125)-labeled monoclonal antibodies against neurospecific enolase and mouse plasma IgG1 were injected intravenously to rats immediately after unilateral occlusion of the middle cerebral artery. Radioactivity of I(125)-labeled monoclonal antibodies against neurospecific enolase in the brain tissue prog...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-005-0037-4
更新日期：2004-10-01 00:00:00
abstract：:The micronucleus test was used tu study the possibility of inducing cross-adaptive response in mouse bone marrow cells in vivo with an 850 nm infrared light modulated by a 101 Hz frequency, emitted by a light therapy device "Kurator". We demonstrated that this exposure led to a substantial reduction of cytogenetic cel...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-009-0522-2
更新日期：2009-04-01 00:00:00
abstract：:We developed an optimal protocol for preparing and culturing of olfactory ensheathing cells from human olfactory mucosa. Using this protocol, we obtained a culture enriched with human olfactory ensheathing cells. Immunofluorescence analysis by simultaneous expression of GFAP and p75NTR markers showed that the content ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-018-4025-x
更新日期：2018-03-01 00:00:00
abstract：:The time course of drug adsorption and desorption, exposure of soft contact lenses in a drug solution needed for maximum saturation, and the duration of lens wearing during which the drug was transported from the lens and exhibited its therapeutic activity were studied. The possibility of using computer simulation for...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-013-2332-9
更新日期：2013-12-01 00:00:00
abstract：:The location and level of IL-8 and TGF-beta2 expression in the fimbrial compartment of fallopian tubes and IL-10 expression in the endometrium of women with pyoinflammatory adnexal diseases were studied by in situ hybridization. These diseases are associated with considerable changes in the levels of local production ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/a:1024193216377
更新日期：2003-03-01 00:00:00
