Abstract：
:Pial arteries of different diameter were studied in intact rats and after 6-month modeling of chronic tobacco smoking in rats. Expression of tachykinin NK1 receptors in pial arteries was studied by biomicroscopy and immunohistochemical methods. Chronic tobacco smoking induced considerable reorganizations of the arterial bed. The intensity of changes depended on the diameter of vessels. In small pial vessels that directly participate in the blood supply to the brain, pronounced vasodilatation and enhanced expression of NK1 receptors in the endothelium mediating the effects of substance P were observed; the number of these vessels also increased. The intensity of the response to tobacco smoke components decreased with increasing vessel diameter.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Zakharchuk NV,Chertok VM,Nevzorova VA,Gonchar EYdoi
10.1007/s10517-017-3792-0subject
Has Abstractpub_date
2017-07-01 00:00:00pages
313-316issue
3eissn
0007-4888issn
1573-8221pii
10.1007/s10517-017-3792-0journal_volume
163pub_type
杂志文章abstract：:Histaminergic contractile reactions of smooth muscles in rabbit lobar pulmonary arteries were studied using in vitro mechanographic technique. Histamine via activation of H-receptors induced a dose-dependent constriction of smooth muscle segments, while endothelium inhibited histamine-induced contractile reactions. Hi...
journal_title：Bulletin of experimental biology and medicine
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abstract：:The effects of Ro 25-6981 (selective NMDA receptor blocker) in a dose stimulating neurogenesis on repeated learning, reversal learning, and memory reconsolidation were studied in adult rats in Morris water maze. Ro 25-6981 facilitated repeated learning 13 days after injection, but did not influence reversal learning. ...
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journal_title：Bulletin of experimental biology and medicine
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更新日期：2006-10-01 00:00:00
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更新日期：2010-07-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
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更新日期：2013-03-01 00:00:00
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更新日期：2012-08-01 00:00:00
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更新日期：2012-10-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
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更新日期：2002-02-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-017-3680-7
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
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更新日期：2007-02-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
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