Abstract：
:Over many years, tick-borne infections remain one of the most serious threats to human health worldwide. The immune response to these infections in a human after confirmed bite by an infected carrier at the early stages of infection in the absence of clinical symptoms can be the first indicator of the presence of the infectious agent in the body. During viral infection, the concentration of IL-1α, IL-8, IL-10, IL-17A, and IFNγ increases; superoxide dismutase also increases, in contrast to bacterial infections. A slight decrease in the concentration is observed only for receptor antagonist IL-1Ra. During the infection caused by bacterial pathogens, very similar profiles of the innate human immune response are observed: activation of IL-1α, IL-8, and IFNα and suppression of superoxide dismutase, IL-1Ra, and IL-17A production. It has been demonstrated, that the immune response is triggered immediately after infection, and changes in the concentration of the main cytokines in the blood plasma can be detected as early as on days 2-5 after tick bite. These results can be useful in developing new methods of emergency diagnosis and prevention of tick-borne infections.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Danchinova GA,Khasnatinov MA,Lyapunova NA,Solovarov IS,Manzarova EL,Lyapunov AV,Petrova IVdoi
10.1007/s10517-019-04405-3subject
Has Abstractpub_date
2019-03-01 00:00:00pages
622-625issue
5eissn
0007-4888issn
1573-8221pii
10.1007/s10517-019-04405-3journal_volume
166pub_type
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