Abstract:
:Experiments on outbred albino rats showed that single intraperitoneal injection of cytochrome P-450 inhibitor 2-diethylaminoethyl-2,2-diphenylpropylacetate (SKF-525A) in a dose of 50 mg/kg before acute poisoning with 1,2-dichloroethane and trichloroethane in a dose of 1.0 LD(50), metabolized in the body to compounds with higher toxicity (the phenomenon of "lethal synthesis") reduced their immunotoxicity by decreasing the formation of their biotransformation products.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Zabrodskii PF,Mandych VG,Germanchuk VGdoi
10.1007/s10517-006-0357-zsubject
Has Abstractpub_date
2006-09-01 00:00:00pages
324-6issue
3eissn
0007-4888issn
1573-8221pii
doijournal_volume
142pub_type
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