Isolation of toxins from Buthus occitanus sp. scorpion and their action on excitability of myelinated nerve.

abstract：:hyperthermia caused hemodynamic disorders in the liver and degenerative and necrobiotic changes in hepatocytes of CBA mice. Total hepatocyte count decreased during restitution, this decrease being most pronounced 30 min after exposure. The number of binucleated cells also markedly decreased. The absence of necrotic ch...

journal_title：Bulletin of experimental biology and medicine

authors： Molodykh OP,Nepomnyashchikh LM,Lushnikova EL,Klinnikova MG

更新日期：2000-09-01 00:00:00

abstract：:The effect of non-benzodiazepine anxiolytics on the ethanol-induced hyperlocomotion and behavioral sensitization was assessed in male DBA/2 mice. Selank that enhances activity of the endogenous opioid system (0.3 mg/kg, intraperitoneally), similar to the nonselective opiate receptor blocker naloxone (1.0 mg/kg, intrap...

journal_title：Bulletin of experimental biology and medicine

authors： Kolik LG,Nadorova AV,Seredenin SB

更新日期：2016-11-01 00:00:00

abstract：:Incomplete varying obstruction of the urinary tract was reproduced by injecting artificial stomatological material into the rat bladder. Inflammatory changes and nephrosclerosis were detected in the renal tissue on days 14 and 21 of the experiment. Urinary concentration of total protein and activity of γ-glutamylamino...

journal_title：Bulletin of experimental biology and medicine

authors： Sosnin DA,Novochadov VV,Ostrovsky OV

更新日期：2013-04-01 00:00:00

abstract：:Groups of microRNA genes, methylation of which is associated with the initial (I-II) stages of breast cancer, are determined, and new markers and marker systems for the disease diagnosis were created on the basis of these data. A total of 14 genes in which methylation was associated with breast cancer were identified ...

journal_title：Bulletin of experimental biology and medicine

authors： Braga EA,Filippova EA,Loginov VI,Pronina IV,Burdennyi AM,Kazubskaya TP,Fridman MV,Khodyrev DS,Kushlinskii NE

更新日期：2019-12-01 00:00:00

abstract：:We studied plus-maze behavior of inbred Krushinskii-Molodkina, Wistar, and black-hooded rats (originating from the Long-Evans outbred strain) differing by predisposition to audiogenic seizures. The severity of audiogenic seizures partially correlated with anxiety and negatively correlated with the total level of locom...

journal_title：Bulletin of experimental biology and medicine

authors： Surina NM,Kalinina TS,Volkova AV,Malikova LA,Poletaeva II,Rayevsky KS,Fedotova IB

更新日期：2011-05-01 00:00:00

abstract：:We studied the effect of constant illumination for 1 month on female GC (genetic catalepsy) and Wistar rats (control). Light exposure decreased the degree of cataleptic freezing in female GC rats (compared to the control). Norepinephrine concentration in cataleptic rats returned to normal under these conditions: this ...

journal_title：Bulletin of experimental biology and medicine

authors： Klotchkov DV,Alekhina TA,Ukolova TN,Rjazanova MA

更新日期：2008-07-01 00:00:00

abstract：:The study was undertaken to determine the mechanism of carnosine effect on cell proliferation. We studied the effect of carnosine and its derivatives on cell cycle progression in cultured rat pheochromocytoma cells (PC-12). It was found that 48-h incubation of PC-12 cells with carnosine in concentrations of 10-50 mM l...

journal_title：Bulletin of experimental biology and medicine

authors： Rybakova YS,Boldyrev AA

更新日期：2012-11-01 00:00:00

abstract：:Preliminary injection of succinic semialdehyde into animals in experiments with hypoxia led to a lower concentration of free ammonia in their brain tissues than in control experiments in which the compound was not given. The enzyme system of the liver tissue catalyzes the oxidation of NAD-H-2 by succinic semialdeyde a...

journal_title：Bulletin of experimental biology and medicine

authors： Zubovskaya AM,Ostrovskaya RU,Tsybina NM

更新日期：1975-01-01 00:00:00

abstract：:Crystal aggregations of oral fluid from normal subjects and patients with type 2 diabetes mellitus were examined. Morphological signs characterizing crystal aggregations of salivary pools from patients with type 2 diabetes mellitus are described and classified. ...

journal_title：Bulletin of experimental biology and medicine

authors： Selifanova EI,Barer GM,Mkrtumyan AM,Denisov AB

更新日期：2004-09-01 00:00:00

abstract：:Ready dosage form (eye drops) prepared on the basis of recombinant alpha2-IFN exhibits high activity towards herpes simplex type 1 virus in vitro. Systematic study of the antiherpesvirus effect of this drug in combination with modified nucleosides showed an inhibitory effect of the synergic type. Combination of IFN pr...

journal_title：Bulletin of experimental biology and medicine

authors： Vyzhlova EN,Andronova VL,Galegov GA,Malinovskaya VV

更新日期：2006-06-01 00:00:00

abstract：:Morphological changes in the mesenteric lymph nodes of male C57Bl/6 mice and subpopulation composition of lymphocytes in these nodes were studied in experimental acute and chronic ulcerative colitis induced by sodium dextran sulfate. Acute and chronic ulcerative colitis was associated with the development of reactive ...

journal_title：Bulletin of experimental biology and medicine

authors： Postovalova EA,Khochansky DN,Zolotova NA,Gao Y,Makarova OV,Dobrynina MT

更新日期：2016-04-01 00:00:00

abstract：:Interleukin-1beta mRNA, interleukin-1beta receptor mRNA, and erythropoietin receptor mRNA are expressed in the brain of (CBAxC57Bl)F1 mice. Immunization with sheep erythrocytes stimulated the expression of these cytokines in the cerebral hemispheres. Injection of recombinant erythropoietin reduced expression of interl...

journal_title：Bulletin of experimental biology and medicine

authors： Poveshchenko AF,Markova EV,Korotkova NA,Yakushenko EV,Abramov VV,Kozlov VA

更新日期：2002-01-01 00:00:00

abstract：:The possibility of using hyaluronidase for the regulation of the state of different pools of mesenchymal precursors in vivo was demonstrated. The reaction of mesenchymal precursor cells depended on the dose of the enzyme. Administration of hyaluronidase in a dose of 20 U/mouse increased the content of stromal precurso...

journal_title：Bulletin of experimental biology and medicine

authors： Goldberg ED,Dygai AM,Zyuz'kov GN,Zhdanov VV,Simanina EV,Gur'yantseva LA

更新日期：2007-04-01 00:00:00

abstract：:Experiments on rats showed that the lymphoprotective effect of Perftoran manifests in stimulation of contractile activity of myocytes in the wall and valve cusps of lymphatic microvessels, which in turn activates the pump and capacitive functions of the lymphatic system and improves central lymph outflow. These change...

journal_title：Bulletin of experimental biology and medicine

authors： Mukhutdinova FI,Khafiz'janova RKh,Triandafilov KA,Mukhutdinov DA

更新日期：2010-11-01 00:00:00

abstract：:A course of ascovertin therapy reduced manifestations of perifocal inflammation and atresia of growing follicles, corrected vascular disorders and changes in the tissue volume ratios outside the necrotic zone after monopolar coagulation of the ovaries in rats. The drug prevented the increase in blood viscosity, erythr...

journal_title：Bulletin of experimental biology and medicine

authors： Logvinov SV,Plotnikov MB,Tikhonovskaya OA,Bukharina IY,Maslov MY,Petrova MS

更新日期：2003-04-01 00:00:00

abstract：:Activities of antioxidant enzymes, vitamin E level, lactate dehydrogenase isoenzyme spectrum, and effects of melatonin on these parameters were studied in the myocardium of rats aged 6, 12, 18, and 24 months exposed to different illumination regimens. The greatest number of changes was recorded in rats exposed to perm...

journal_title：Bulletin of experimental biology and medicine

authors： Khizhkin EA,Ilukha VA,Ilyina TN,Unzhakov AR,Vinogradova IA,Anisimov VN

更新日期：2010-09-01 00:00:00

abstract：:We studied the influence of the characteristics of oxide porous coatings on osteogenesis and integration of new bone tissue and titanium implant surface in the ectopic osteogenesis test. Implants with coating with pore size 2-20 μ exhibit better osteogenic and osteoconductive characteristics than implants with homogen...

journal_title：Bulletin of experimental biology and medicine

authors： Nadezhdin SV,Zubareva EV,Burda YE,Kolobov YR,Ivanov MB,Khramov GV,Afanas'ev AY

更新日期：2017-04-01 00:00:00

abstract：:Acute experiments on cats showed that injection of catecholamines induced unidirectional shifts in right and left atrial pressure in 70% cases (these shifts were positive in one half of cats and negative in the other half). In 30% cases, the left and right atrial pressures changed in opposite direction: right atrial p...

journal_title：Bulletin of experimental biology and medicine

authors： Tkachenko BI,Evlakhov VI,Poyasov IZ

更新日期：2005-01-01 00:00:00

abstract：:We studied the effect of terahertz radiation at NO frequencies 150.176-150.664 GHz on gaseous and electrolyte composition of the blood in albino rats during stress. Partial or complete recovery of the studied parameters of blood gases and electrolytes in stressed animals was observed after 15- and 30-min terahertz irr...

journal_title：Bulletin of experimental biology and medicine

authors： Kirichuk VF,Tsymbal AA

更新日期：2010-12-01 00:00:00

abstract：:Hypoxia-induced immediate expression of transcription factor HIF-1α in the brain cortex is regulated by succinate produced in both the tricarbonic acid cycle and GABA shunt reactions and is induced by succinate-containing drugs. These facts prove the existence of succinate-dependent signalling regulation involved in i...

journal_title：Bulletin of experimental biology and medicine

authors： Lukyanova LD,Kirova YI,Germanova EL

更新日期：2018-01-01 00:00:00

abstract：:Model experiments on biomicroscopy of mesenteric microvessels in laboratory rats were performed to evaluate the effect of natural metabolites (e.g., amino acid glycine) on the microcirculation. The effect of glycine was determined from a change in the diameter of arterioles. Application of glycine (0.1 ml, 1 M) to the...

journal_title：Bulletin of experimental biology and medicine

authors： Podoprigora GI,Nartsissov YR

更新日期：2009-03-01 00:00:00

abstract：:The effects of fullerene C(60) nanocomposites on human platelet aggregation induced by ADP, ristocetin, and collagen were studied. The nanocomposite containing fullerene C(60) in polyvinyl pyrrolidone solution did not change platelet aggregation, while fullerene C(60) in crown ether and Twin-80 solutions inhibited ADP...

journal_title：Bulletin of experimental biology and medicine

authors： Vaschenko VI,Samonin VV,Popov VA,Antonenkova EV,Nikonova VJ,Vilyaninov VN,Podvjaznikov ML,Kidalov VN,Titulova TB,Vaschenko TN

更新日期：2012-03-01 00:00:00

abstract：:Changes in bile ducts in cholestasis are characterized by activation of proliferation and hypertrophy of cholangiocytes and degenerative and necrobiotic changes in ductal epithelium. Long-term cholestasis led to massive necrosis of cholangiocytes. Inflammatory changes in the choledochal mucosa were most pronounced in ...

journal_title：Bulletin of experimental biology and medicine

authors： Dreval' AA,Perminova GI,Kuznetsov NA,Sokolov AA,Laberko LA,Ryzhkova LV

更新日期：2002-04-01 00:00:00

abstract：:The gene expression profiles of MDA-MB-231 cell line of breast cancer and xenografts derived from this tumor in murine model were analyzed using GeneChip Human Transcriptome array 2.0 platform (Affymetrix). A more than 1000-fold increase in the MIR1973 gene expression was observed in the xenografts compared to the ori...

journal_title：Bulletin of experimental biology and medicine

authors： Fomicheva KA,Knyazev EN,Mal'tseva DV

更新日期：2017-09-01 00:00:00

abstract：:The local anaphylactic reaction and the effects of histamine during blocking of the slow sodium-calcium channels by isoptine were investigated in the spontaneously contracting oracle of the atrium of a guinea pig previously sensitized to egg albumin. Simultaneously with the intracellular recording of the potentials, i...

journal_title：Bulletin of experimental biology and medicine

authors： Khodorov BI,Voronovitskii EG,Ignat'eva VB

更新日期：1975-01-01 00:00:00

abstract：:We studied the role of DNA methylation in the mechanisms of amnesia in edible snails, which was induced by impairment of conditioned food aversion memory reconsolidation with NMDA glutamate receptor antagonist. The effects of DNA methyltransferase inhibitors were shown to depend on the stage of amnesia. At the early s...

journal_title：Bulletin of experimental biology and medicine

authors： Solntseva SV,Filatova TS,Nikitin PV,Bredov DV,Kozyrev SA,Nikitin VP

更新日期：2014-02-01 00:00:00

abstract：:Number and size of aggregated lymphoid nodules in the small intestine of mice exposed to radiation using a γ-irradiation unit GOBO-60 with 137Cs source were measured using the methods of visual microscopy and morphometry. Morphological status of the nodules was estimated on days 4, 28, 60, and 90 after the exposure. S...

journal_title：Bulletin of experimental biology and medicine

authors： Klochkova SV,Kvaratskheliya AG,Alekseeva NT,Nikityuk DB

更新日期：2017-12-01 00:00:00

abstract：:The production of blood radicals and activity of superoxide dismutase in erythrocytes increased in rats with contact burn trauma (20%). In animals with burn trauma antioxidant activity of the plasma was much lower, while myeloperoxidase content in the lung tissue and epidermis was higher than in control rats. The comp...

journal_title：Bulletin of experimental biology and medicine

authors： Mikhal'chik EV,Ivanova AV,Anurov MV,Titkova SM,Pen'kov LY,Korkina LG

更新日期：2004-09-01 00:00:00

abstract：:We studied the effect of vasopressin analogue desglycinamide-arginine-vasopressin on changes in platelet hemostasis produced by intragastric administration of Ticlid or clopidogrel (inhibitors of ADP-induced platelet aggregation). Intranasal administration of the peptide under conditions of hemorrhagic diathesis produ...

journal_title：Bulletin of experimental biology and medicine

authors： Golubeva MG,Grigoreva ME,Smirnova MP

更新日期：2005-08-01 00:00:00

abstract：:The dynamics of LPO marker malondialdehyde formation and peroxidase-destroying activity was studied in homogenized organs of guinea pigs, immunized with thermoextracts from S and L forms Brucella abortus I-206. The L form brucella thermoextract exhibited a lower reactogenicity and adequately activated the antioxidant ...

journal_title：Bulletin of experimental biology and medicine

authors： Dubrovina VI,Balakhonov SV,Yurieva OV,Starovoitova TP,Barannikova NL,Tokareva LE,Pyatidesyatnikova AB,Yastremskaya KY,Shkaruba TT

更新日期：2018-06-01 00:00:00