On the mechanism of anti-ischemic effects of afobazole.

Abstract:

:The anti-ischemic effect of synthetic and pharmacologically tested anxiolytic afobazole (10 mg/kg intravenously) was studied on anesthetized rats with acute endocardial ischemia caused by isoproterenol infusion (20 mg/kg/min). A calcium antagonist verapamil (1 mg/kg intravenously) belonging to the group of phenyl alkyl amine derivatives was used as the reference drug. Afobazole and verapamil were shown to exhibit anti-ischemic activity in this experimental model, which was seen from significant decrease in ST segment depression on ECG. The neuroprotective effect of afobazole is to a great extent related to its affinity for σ1 receptors. Therefore, a special series was performed to evaluate the anti-ischemic effect of afobazole after blockade of these receptors with haloperidol (0.5 mg/kg intravenously). Afobazole exhibited no anti-ischemic activity under these conditions. σ1 receptor blockade had no effect on anti-ischemic activity of verapamil. Our results suggest that the agonistic effect of afobazole on σ1 receptors in cardiomyocytes contributes to anti-ischemic activity of this agent.

journal_name

Bull Exp Biol Med

authors

Seredenin SB,Tsorin IB,Vititnova MB,Stolyaruk VN,Chichkanov GG,Kryzhanovskii SA

doi

10.1007/s10517-013-2246-6

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

760-3

issue

6

eissn

0007-4888

issn

1573-8221

journal_volume

155

pub_type

杂志文章
  • Dihydroquercetin and Fucoidin Inhibit the Increase of Angiotensin-Converting Enzyme Activity in the Rat Aorta after Irradiation.

    abstract::The time course of angiotensin-converting enzyme activity in the rat aorta after fractionated exposure to ionizing radiation and the effects of dihydroquercetin and fucoidin on this parameter were studied. Male Wistar rats were exposed to single or repeated (fractionated) X-ray radiation in a dose of 2.5 Gy at 200 kV....

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-018-4170-2

    authors: Korystova AF,Kublik LN,Kim YA,Levitman MK,Shaposhnikova VV,Korystov YN

    更新日期:2018-07-01 00:00:00

  • Effects of 5-Pyrimidinol Derivative SNK-41 on Cytokine Profile of Mice with Lewis Lung Carcinoma.

    abstract::We studied the effects of SNK-411, a new 5-pyrimidinol derivative, on serum cytokine profile of C57Bl/6 mice with Lewis lung carcinoma. The compound was injected intraperitoneally in doses of 25 and 50 mg/kg. A significant (by 3.5 times) increase in serum IL-4 content was detected in mice with tumors on day 9 of tumor...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-016-3202-z

    authors: Kuznetsova OS,Tallerova AV,Nikitin SV,Kovalenko LP

    更新日期:2016-02-01 00:00:00

  • Effect of tissue phospholipid composition on synergistic interactions between sympathetic and parasympathetic systems.

    abstract::The content of phospholipids in various tissues was studied during synergistic interaction between two branches of the autonomic nervous system. We found higher myocardial content of choline-containing phospholipids and lower rigidity of erythrocyte membranes in rabbits with pronounced sympathetic potentiation of the ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1016203713719

    authors: Lychkova AE,Smirnov VM

    更新日期:2002-04-01 00:00:00

  • Effect of cholinergic and adrenergic receptor blockade on arrhythmogenic activity of endothelin-1 during inhibition of nitric oxide synthesis in awake mice.

    abstract::We studied the effects of blockade of nicotinic receptors in sympathetic and parasympathetic ganglia (hexamethonium), muscarinic receptors (atropine), and beta1-adrenoceptors (atenolol) on arrhythmogenic activity of endothelin-1 during inhibition of nitric oxide synthesis with Nomega-nitro-L-arginine in NMRI mice. Atr...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/b:bebm.0000028115.53995.e0

    authors: Lobanov AV,Rzhevskii DI,Korshunov VA,Murashev AN

    更新日期:2004-02-01 00:00:00

  • Comparative study of pharmacological activity of afala on the model of hormone-induced prostatitis in rats.

    abstract::Afala (ultralow-dose antibodies to prostate-specific antigen) injected for 60 days to rats with hormone-induced prostatitis caused by sulpiride prevented the development of prostatic hyperplasia and reduced the severity of histological changes. The effect of Afala was superior to that of the reference drug (Serenoa re...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-007-0409-z

    authors: Savelieva KV,Borovskaya TG,Kheyfets IA,Dugina JL,Sergeeva SA,Epstein OI

    更新日期:2007-11-01 00:00:00

  • Selective Cytotoxicity of Manganese Nanoparticles against Human Glioblastoma Cells.

    abstract::Toxicity of different types of manganese nanoparticles against glioblastoma U-87MG and U-251 cells and normal human cells was studied using MTT test. The selectivity of the toxic effect of nanoparticles was evaluated as the ratio of 50% cytotoxic concentration (СС50) for human embryos fibroblasts (FECh-15) to their СС...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-017-3849-0

    authors: Razumov IA,Zav'yalov EL,Troitskii SY,Romashchenko AV,Petrovskii DV,Kuper KE,Moshkin MP

    更新日期:2017-08-01 00:00:00

  • Mechanisms of cervico-vestibular-oculomotor disorders at the early stages of Parkinson's disease.

    abstract::We studied the interaction of the oculomotor, cervical, and vestibular systems using a specially developed technique. A series of two tests were performed on 26 healthy subjects and 42 patients with stages I-II Parkinson's disease receiving and not receiving treatment. In coordinated tests, all amplitude-time characte...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-011-1443-4

    authors: Shvetsov AY,Ivanova EA,Chigalejchik LA,Baziyan BKh

    更新日期:2011-11-01 00:00:00

  • Intranasal Insulin Restores Metabolic Parameters and Insulin Sensitivity in Rats with Metabolic Syndrome.

    abstract::We studied the effect of 10-week treatment with intranasal insulin (0.5 IU/day) on glucose tolerance, glucose utilization, lipid metabolism, functions of pancreatic β cells, and insulin system in the liver of rats with cafeteria diet-induced metabolic syndrome. The therapy reduced body weight and blood levels of insul...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-017-3762-6

    authors: Derkach KV,Ivantsov AO,Chistyakova OV,Sukhov IB,Buzanakov DM,Kulikova AA,Shpakov AO

    更新日期:2017-06-01 00:00:00

  • Effect of semi-compulsory alcoholization on brown fat in mice.

    abstract::We studied brown adipose tissue isolated from mice receiving 20% ethanol as a single source of fluid. In vitro O2 utilization by brown adipose tissue decreased after one month of forced alcohol intake, but surpassed the control after 3 months of ethanol drinking. The absolute and relative weight of brown adipose tissu...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1014590710930

    authors: Elsukova EI,Medvedev LN,Kudryavtseva NA

    更新日期:2001-12-01 00:00:00

  • Electron-histochemical location of cathepsin D and elastase in the uterus.

    abstract::Location of cathepsin D and elastase in rat uterus was studied by electron-histochemical method. Activities of both proteinases in the myometrium was detected in lysosomes of smooth-muscle cells, macrophages, and fibroblasts. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1026391512536

    authors: Ryvnyak VV,Gudumak VS,Dulgieru OF

    更新日期:2003-08-01 00:00:00

  • Adrenocortical system response to induction of inflammation with silicon dioxide in rats with alloxan-induced diabetes mellitus.

    abstract::Alloxan-induced diabetes mellitus in rats was characterized by persistent increase in blood levels of corticosterone, while chronic granulomatous inflammation induced by silicon dioxide and its combination with alloxan-induced diabetes mellitus were associated with transient increase in blood corticosterone level foll...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-010-1026-9

    authors: Kuznetsova NV,Palchikova NA,Selyatitskaya VG,Shkurupiy VA

    更新日期:2010-11-01 00:00:00

  • Antiangiogenic Activity of Alofanib, an Allosteric Inhibitor of Fibroblast Growth Factor Receptor 2.

    abstract::Alofanib is a potential allosteric inhibitor of FGFR2 used in oncology. The inhibitor blocks the extracellular part of the receptor and prevents its binding with the ligand. Alofanib suppressed proliferation of endothelial cells, their migration activity, and ability to form vessellike structures in vitro and signific...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-015-3104-5

    authors: Khochenkov DA,Solomko ES,Peretolchina NM,Ryabaya OO,Stepanova EV

    更新日期:2015-11-01 00:00:00

  • Expression of genes for thioredoxin 1 and thioredoxin 2 in multidrug resistance ovarian carcinoma cells SKVLB.

    abstract::The expression of genes for thioredoxin isoforms Trx1 and Trx2 was studied in sensitive SKOV-3 and resistant SKVLB human ovarian carcinoma cells. The development of doxorubicin resistance was accompanied by a significant increase in the expression of TRX1 gene and less pronounced increase in TRX2 gene expression. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-007-0316-3

    authors: Kalinina EV,Chernov NN,Saprin AN,Kotova YN,Gavrilova YA,Chermnykh NS,Shcherbak NP

    更新日期:2007-09-01 00:00:00

  • Modification of Biochemical Properties of Nitrosothiol by Fe3+ Cation: A Presumable Physiological Role.

    abstract::In the presence of Fe3+ cation, S-nitrosoglutathione (GSNO) loses the potency to inhibit catalase in the system containing hemoglobin (an NO trap) with iron chelator or -SH inhibitor (a "sulfhydric poison" Hg2+). In the absence of hemoglobin, the inhibitory potency is retained in both cases. These properties are chara...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-019-04641-7

    authors: Titov VY,Osipov AN,Ibragimova LG,Petrov VA,Dolgorukova AM

    更新日期:2019-11-01 00:00:00

  • Parameters of cell energy metabolism during stress in laboratory animals and energotropic effect of alpha1-adrenoblocker doxazosin.

    abstract::Cytochemical activity of succinate dehydrogenase and lactate dehydrogenase in blood lymphocytes, activity of hydroperoxides, MDA, and blood plasma antioxidants were studied in experimental animals during immobilization stress after preliminary injection of doxazosin. Preliminary adrenergic receptor blockade prevented ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-005-0064-1

    authors: Vishnevskii EL,Vishnevskii AE,Shabel'nikova EI,Safronova ON,Dreval AA,Topchieva GV,Sukhorukov VS

    更新日期:2004-11-01 00:00:00

  • Role of PI3K, MAPK/ERK1/2, and p38 in implementation of the proliferative and differentiation potential of erythroid progenitors after blood loss.

    abstract::The involvement of PI3K, ERK and p38-dependent signaling system in the regulation of functional activity of erythroid precursors after blood loss (30% of circulating volume) was studied. We demonstrated the important role of PI3K and p38 in the suppression of differentiation of erythroid precursors the contribution of...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-015-2775-2

    authors: Dygai AM,Zhdanov VV,Miroshnichenko LA,Udut EV,Zyuz'kov GN,Simanina EV,Sherstoboev EY,Chaikovskii AV,Stavrova LA,Burmina YV,Khrichkova TY,Reichart DV,Goldberg VE

    更新日期:2015-02-01 00:00:00

  • Possible role of slow sodium-calcium channels in the mechanism of changes in electrical and mechanical activity of guinea pig heart cells in local anaphylaxis (the isoptine effects).

    abstract::The local anaphylactic reaction and the effects of histamine during blocking of the slow sodium-calcium channels by isoptine were investigated in the spontaneously contracting oracle of the atrium of a guinea pig previously sensitized to egg albumin. Simultaneously with the intracellular recording of the potentials, i...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/BF00799305

    authors: Khodorov BI,Voronovitskii EG,Ignat'eva VB

    更新日期:1975-01-01 00:00:00

  • Microcirculatory disturbances in gastric mucosa during ulcer disease and effects of serotonin on their dynamics.

    abstract::Experiments on rat model of stress-induced gastric ulcers revealed marked circulatory disturbances in ulcerated gastric mucosa associated with arteriolar spasm and venous congestion and leading to perivascular edema, diapedesis of erythrocytes, and microhemorrhages. These changes were most pronounced on day 1 after ul...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:

    authors: Khadzhiev OC,Lupal'tsov VI,Simonenkov AP,Klimenko NA,Tatarko SV

    更新日期:2000-09-01 00:00:00

  • Characteristics of human bone marrow mesenchymal stem cells isolated by immunomagnetic selection.

    abstract::Immunophenotype of human bone marrow mesenchymal stem cells was studied after several culturing passages and after cryopreservation. Immunocytochemical analysis showed that bone marrow mesenchymal stem cells acquired homogeneity during in vitro culturing, but initially contained heterogeneous populations. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-006-0108-1

    authors: Lagar'kova MA,Lyakisheva AV,Filonenko ES,Volchkov PY,Rubtsova KV,Gerasimov YV,Chailakhyan RK,Kiselev SL

    更新日期:2006-01-01 00:00:00

  • Phenotype of peripheral blood cells mobilized by granulocyte colony-stimulating factor in patients with chronic heart failure.

    abstract::Administration of granulocyte CSF preparation to patients with chronic heart failure produced a hemostimulating effect and increased the content of leukocytes and neutrophils in the peripheral blood. Granulocyte CSF induced mobilization of bone marrow progenitor cells into the peripheral blood. The content of hemopoie...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10517-012-1659-y

    authors: Konenkov VI,Pokushalov EA,Poveshchenko OV,Kim II,Romanov AB,Guleva NA,Bernvald VV,Soloviova AO,Yankayte EV,Poveshchenko AF,Karaskov AM

    更新日期:2012-05-01 00:00:00

  • Immunostimulatory effect of gold nanoparticles conjugated with transmissible gastroenteritis virus.

    abstract::Animals were immunized with transmissible gastroenteritis virus conjugated with gold nanoparticles. The resultant antibodies had a higher titer than antibodies produced in response to native virus. Immunization with the antigen-colloidal gold complex led to a significant increase of the peritoneal macrophages respirat...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-011-1350-8

    authors: Staroverov SA,Vidyasheva IV,Gabalov KP,Vasilenko OA,Laskavyi VN,Dykman LA

    更新日期:2011-08-01 00:00:00

  • Selank Inhibits Ethanol-Induced Hyperlocomotion and Manifestation of Behavioral Sensitization in DBA/2 Mice.

    abstract::The effect of non-benzodiazepine anxiolytics on the ethanol-induced hyperlocomotion and behavioral sensitization was assessed in male DBA/2 mice. Selank that enhances activity of the endogenous opioid system (0.3 mg/kg, intraperitoneally), similar to the nonselective opiate receptor blocker naloxone (1.0 mg/kg, intrap...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-016-3544-6

    authors: Kolik LG,Nadorova AV,Seredenin SB

    更新日期:2016-11-01 00:00:00

  • CYP1A2 and CYP2D6 Gene Polymorphisms in Schizophrenic Patients with Neuroleptic Drug-Induced Side Effects.

    abstract::Polymorphic variants of CYP1A2 and CYP2D6 genes of the cytochrome P450 system were studied in patients with schizophrenia with drug-induced motor disorders and hyperprolactinemia against the background of long-term neuroleptic therapy. We revealed an association of polymorphic variant C-163A CYP1A2*1F of CYP1A2 gene w...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-016-3250-4

    authors: Ivanova SA,Filipenko ML,Vyalova NM,Voronina EN,Pozhidaev IV,Osmanova DZ,Ivanov MV,Fedorenko OY,Semke AV,Bokhan NA

    更新日期:2016-03-01 00:00:00

  • Methylarginines in Mice with Experimental Atherosclerosis.

    abstract::We studied the dynamics of indexes for the system of endogenous regulation of NO bioavailability. The content of NO synthase inhibitors (monomethylarginine and asymmetric dimethylarginine) in the blood of mice was measured after intraperitoneal injections of a nonionic surfactant poloxamer 407 for 2 and 14 weeks. The ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-015-3086-3

    authors: Gilinsky MA,Sukhovershin RA,Cherkanova MS

    更新日期:2015-11-01 00:00:00

  • Role of I(1)-imidazoline receptors and alpha2-adrenoceptors in hemodynamic effects of moxonidine administration into the rostroventrolateral medulla.

    abstract::Local injection of 4 nmol moxonidine (unilaterally) into the rostroventrolateral medulla of spontaneously hypertensive rats (SHR-SP) decreased mean blood pressure and heart rate by 24+/-3 and 3+/-4%, respectively. Pretreatment with the I1/alpha2-receptor antagonist efaroxan abolished the moxonidine-induced decrease in...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/a:1017943901070

    authors: Khokhlova ON,Murashev AN,Medvedev OS

    更新日期:2001-04-01 00:00:00

  • Experimental gastric ulcer: gastro- and duodenoprotective effects of sibusol.

    abstract::We studied the influence of pretreatment with chemical mildronate analogue sibusol on the course of experimental gastric ulcer in rats. Sibusol produced a protective effects on the stomach and duodenum. ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1023/b:bebm.0000024380.24282.0b

    authors: Lychkova AE,Savchuk VI,Smirnov VM

    更新日期:2004-01-01 00:00:00

  • Peculiarities of autonomic regulation assessed by variability of hemodynamic parameters in rats with different stress resistance.

    abstract::Analysis of contribution of sympathetic and parasympathetic systems into heart rate variability carried out using atenolol and atropine showed that August rats are characterized by enhanced tone of the sympathetic system and reduced tone of the parasympathetic system compared to Wistar rats. Reduced tone of the parasy...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-006-0375-x

    authors: Kirillina TN,Usacheva MA,Belkina LM

    更新日期:2006-10-01 00:00:00

  • Changes in Functional Activity of Neutrophils and Monocytes Isolated from the Peripheral Blood of Women at Different Phases of the Menstrual Cycle.

    abstract::We studied functional activity of neutrophilic granulocytes and monocytes isolated from the peripheral blood of women during the follicular and luteal phases of the menstrual cycle. It was shown that phagocytic activity of neutrophilic granulocytes increases, their intracellular oxygen-dependent bactericidal activity ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-018-4318-0

    authors: Smirnova TG,Savochkina AY,Dolgushin II,Nikushkina KV,Samuseva IV

    更新日期:2018-12-01 00:00:00

  • Effect of 2-aminoadamantane derivatives on behavior of mice in a modified light/dark test.

    abstract::The effects of two derivatives of 2-aminoadamantane, enantiomers J447H and J579, on the behavior of male and female C57Bl/6J mice were studied using a modified light/dark test. The substances differed by their effects on the behavior of male mice. J579 reduced the number of rearings. J447H in a dose of 1 mg/kg affecte...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-014-2725-4

    authors: Avgustinovich DF,Fomina MK,Suslov EV,Tolstikova TG,Volcho KP,Salakhutdinov NF

    更新日期:2014-12-01 00:00:00

  • Mechanisms of protective effect of Dicarbamin on the blood system in cytostatic treatment.

    abstract::The effect of Dicarbamin preparation on hemopoiesis suppressed with cyclophosphamide was studied in animal experiments. It was shown that Dicarbamin produced a protective effect on granulocytic hemopoietic steam. This property of the preparation is determined by both protection of immature granulocytic cells at early ...

    journal_title:Bulletin of experimental biology and medicine

    pub_type: 杂志文章

    doi:10.1007/s10517-011-1138-x

    authors: Nebolsin VE,Zhdanov VV,Zyuzkov GN,Udut EV,Khrichkova TY,Simanina EV,Stavrova LA,Miroshnichenko LA,Chaikovskiy AV,Dygai AM

    更新日期:2011-01-01 00:00:00