Abstract:
:The anti-ischemic effect of synthetic and pharmacologically tested anxiolytic afobazole (10 mg/kg intravenously) was studied on anesthetized rats with acute endocardial ischemia caused by isoproterenol infusion (20 mg/kg/min). A calcium antagonist verapamil (1 mg/kg intravenously) belonging to the group of phenyl alkyl amine derivatives was used as the reference drug. Afobazole and verapamil were shown to exhibit anti-ischemic activity in this experimental model, which was seen from significant decrease in ST segment depression on ECG. The neuroprotective effect of afobazole is to a great extent related to its affinity for σ1 receptors. Therefore, a special series was performed to evaluate the anti-ischemic effect of afobazole after blockade of these receptors with haloperidol (0.5 mg/kg intravenously). Afobazole exhibited no anti-ischemic activity under these conditions. σ1 receptor blockade had no effect on anti-ischemic activity of verapamil. Our results suggest that the agonistic effect of afobazole on σ1 receptors in cardiomyocytes contributes to anti-ischemic activity of this agent.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Seredenin SB,Tsorin IB,Vititnova MB,Stolyaruk VN,Chichkanov GG,Kryzhanovskii SAdoi
10.1007/s10517-013-2246-6subject
Has Abstractpub_date
2013-10-01 00:00:00pages
760-3issue
6eissn
0007-4888issn
1573-8221journal_volume
155pub_type
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