Abstract：
:Antitumor efficiencies of cytostatics dioxadet, cisplatin, mitomycin C, melphalan, and paclitaxel after a single intraperitoneal or intravenous injection in doses of 1.5, 4, 1.5, 2, and 5 mg/kg, respectively, were studied on the model of transplanted ovarian tumor in 124 rats. The antitumor effects were evaluated by the increase in median survival. Dioxadet, cisplatin, and melphalan injected intraperitoneally significantly prolonged the lifespan median - by 79, 88, and 114%, respectively, and were in fact ineffective, when injected intravenously. Intraperitoneal mitomycin C prolonged lifespan median by just 35%, intravenous - by 152%. Paclitaxel injected intraperitoneally and intravenously prolonged the lifespan median by 45 and 81%, respectively.
journal_name
Bull Exp Biol Medjournal_title
Bulletin of experimental biology and medicineauthors
Bespalov VG,Vyshinskaya EA,Vasil'eva IN,Semenov AL,Maidin MA,Barakova NV,Stukov ANdoi
10.1007/s10517-017-3621-5subject
Has Abstractpub_date
2017-01-01 00:00:00pages
383-386issue
3eissn
0007-4888issn
1573-8221pii
10.1007/s10517-017-3621-5journal_volume
162pub_type
杂志文章abstract：:The expression of mRNA of proteins involved in the transformations of cytostatics (cytochrome P-450 1A1 and 1B1 isoforms) and genes encoding proteins participating in their regulation (Ah receptor, AHRR and ARNT) in intestinal tumors and intact portions of the intestine were studied. The expression of cytochrome P-450...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-008-0261-9
更新日期：2008-08-01 00:00:00
abstract：:At the early stages of development (3 months), transplants from bone marrow donors subjected to single in vivo stimulation (curettage, administration of BMP-2 or antigenic complex of S. typhimurium) 1 day before transplantation were characterized by significantly elevated content of nucleated cells (by 1.4, 1.9 and 2....
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-017-3754-6
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abstract：:In patients with ovarian cancer, the colony-forming capacity and radiosensitivity of clonogenic tumor cells from the primary node and metastases (ascites) differed considerably. ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/a:1012362804949
更新日期：2001-06-01 00:00:00
abstract：:Stimulation of NO-producing activity of macrophages infected with tick-borne encephalitis virus was demonstrated. Activity of NADPH-diaphorase, inducible NO synthase, and cytochrome oxidase, a heme-containing mitochondrial enzyme reflecting NO production by the nitrite reductase pathway was observed against the backgr...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-008-0087-5
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abstract：:The interaction between dopamine D1 and D2 receptors plays a role in immunomodulation. The results of thus interaction depends on the degree of receptor activation with selective agonists in different doses. Combined treatment with agonists of D1 and D2 receptors in high doses had a synergistic effect in the mechanism...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-006-0218-9
更新日期：2006-05-01 00:00:00
abstract：:The effects of melatonin, aluminum oxide, and polymethylsiloxane complex on the expression of LYVE-1 (lymphatic vessel endothelial hyaluronan receptor) in the liver were studied in db/db mice with experimental obesity and type 2 diabetes mellitus. The complex or placebo was administered daily by gavage from week 8 to ...
journal_title：Bulletin of experimental biology and medicine
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doi：10.1007/s10517-016-3592-y
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abstract：:Nadcin in a dose of 90 mg/kg administered to dogs with subacute stage of ischemia-reperfusion myocardial injury immediately after blood flow resumption normalized redox potential of cardiomyocytes and mitochondria and restored the total content of adenyl and pyridine nucleotides. The decrease in the synthesis of ATP a...
journal_title：Bulletin of experimental biology and medicine
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doi：10.1007/s10517-008-0268-2
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journal_title：Bulletin of experimental biology and medicine
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doi：10.1007/s10517-016-3258-9
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abstract：:Cytochemical activity of succinate dehydrogenase and lactate dehydrogenase in blood lymphocytes, activity of hydroperoxides, MDA, and blood plasma antioxidants were studied in experimental animals during immobilization stress after preliminary injection of doxazosin. Preliminary adrenergic receptor blockade prevented ...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-005-0064-1
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journal_title：Bulletin of experimental biology and medicine
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doi：10.1007/s10517-012-1801-x
更新日期：2012-09-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
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journal_title：Bulletin of experimental biology and medicine
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更新日期：2009-07-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
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journal_title：Bulletin of experimental biology and medicine
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journal_title：Bulletin of experimental biology and medicine
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doi：10.1007/s10517-008-0166-7
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journal_title：Bulletin of experimental biology and medicine
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
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更新日期：2009-10-01 00:00:00
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journal_title：Bulletin of experimental biology and medicine
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更新日期：2004-09-01 00:00:00
abstract：:We studied the effects and mechanisms of action of NaHS, an H2S donor, on isolated phenylephrine-precontracted bovine mesenteric lymph nodes. NaHS induced concentration-dependent relaxation of lymph nodes. Removal of the endothelium reduced, but did not abolish the relaxing effect of NaHS. The relaxing effect was redu...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-020-04848-z
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journal_title：Bulletin of experimental biology and medicine
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journal_title：Bulletin of experimental biology and medicine
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journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1007/s10517-005-0377-0
更新日期：2005-06-01 00:00:00
abstract：:Morphological study of allotransplants of rat embryonic neocortex 14-18 months after transplantation into the neocortex, lateral cerebral ventricle, and sciatic nerve of adult animals revealed death of nerve and glial cells in the delayed postoperation period independently on the site of transplantation. After heterot...
journal_title：Bulletin of experimental biology and medicine
pub_type： 杂志文章
doi：10.1023/b:bebm.0000008989.24898.df
更新日期：2003-09-01 00:00:00
